Drug targeting of HIV-1 RNA·DNA hybrid structures: Thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replication

Biochemistry

Volumn 43, Issue 30, 2004, Pages 9732-9742

  Li, Tsai Kun ^a,b   Barbieri, Christopher M ^a   Lin, Hsin Chin ^c   Rabson, Arnold B ^a,c,d   Yang, Gengcheng ^e   Fan, Yupeng ^e   Gaffney, Barbara L ^e   Jones, Roger A ^e   Pilch, Daniel S ^a,d  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c RUTGERS UNIVERSITY   (United States)

^d RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^e RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; CALORIMETRY; CHEMOTHERAPY; DEGRADATION; DRUG INTERACTIONS; ENZYMES; RNA; TITRATION; ULTRAVIOLET RADIATION; VIRUSES;

HUMAN IMMUNODEFICIENCY VIRUS (HIV); MUTATIONS; TRANSCRIPTION;

BIOCHEMISTRY;

2 DEOXYSTREPTAMINE; AMINOGLYCOSIDE DERIVATIVE; CHIMERIC PROTEIN; NEOMYCIN; PAROMOMYCIN; RIBONUCLEASE H; RIBOSTAMYCIN; RNA DIRECTED DNA POLYMERASE; RNA DNA DUPLEX; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; BINDING AFFINITY; CALORIMETRY; CHEMOTHERAPY; DNA RNA HYBRIDIZATION; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE MUTATION; GENETIC VARIABILITY; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REVERSE TRANSCRIPTION; RNA DEGRADATION; THERMODYNAMICS; ULTRAVIOLET MELTING TITRATION CALORIMETRY; VIRUS INHIBITION; VIRUS MORPHOLOGY; VIRUS PARTICLE; VIRUS REPLICATION;

AMINOGLYCOSIDES; BINDING, COMPETITIVE; CIRCULAR DICHROISM; DNA, VIRAL; DRUG DELIVERY SYSTEMS; ENZYME ACTIVATION; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; HYDROLYSIS; NEOMYCIN; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES; PAROMOMYCIN; REVERSE TRANSCRIPTASE INHIBITORS; RIBONUCLEASE H, CALF THYMUS; RIBOSTAMYCIN; RNA, VIRAL; THERMODYNAMICS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 3343019139     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0497345     Document Type: Article

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