Synthesis and biological evaluation of conformationally constrained analogues of the antitubercular agent ethambutol

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 17, 2007, Pages 5866-5876

  Faugeroux, Vanessa ^a   Génisson, Yves ^a   Salma, Yahya ^a   Constant, Patricia ^b   Baltas, Michel ^a  

^a UPS)   (France)

^b INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

Author keywords

Arabinosyltransferase; Ethambutol; Hydrocyanation; Imine; Prolinol; Reductive coupling; Tuberculosis

Indexed keywords

2 (HYDROXYMETHYL) 5 (1 HYDROXYBUTAN 2 YLAMINO)METHYLPYRROLIDINE; ETHAMBUTOL; PROLINOL DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONFORMATIONAL TRANSITION; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; MYCOBACTERIUM TUBERCULOSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

ANTITUBERCULAR AGENTS; DRUG DESIGN; ETHAMBUTOL; IMINES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MYCOBACTERIUM TUBERCULOSIS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 34447274050     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.064     Document Type: Article

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