CCK receptors and cancer

Current Topics in Medicinal Chemistry

Volumn 7, Issue 12, 2007, Pages 1232-1238

  Baldwin, Graham S ^a,b   Shulkes, Arthur ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b AUSTIN HEALTH   (Australia)

Author keywords

Cholecystokinin; Colorectal cancer; Gastric; Gastric cancer; Pancreatic cancer

Indexed keywords

ANTIBODY CONJUGATE; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ B RECEPTOR; CISPLATIN; DEVAZEPIDE; FLUOROURACIL; GASTRIMMUNE; GASTRIN; GASTRIN DIPHTHERIA CONJUGATE; LOXIGLUMIDE; MESSENGER RNA; PROGLUMIDE; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ASTROCYTOMA; CANCER INCIDENCE; CANCER RESEARCH; CANCER SURVIVAL; CARCINOGENESIS; CARCINOID; CLINICAL TRIAL; COLORECTAL CANCER; ESOPHAGUS CANCER; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; LUNG SMALL CELL CANCER; MALIGNANT TRANSFORMATION; MENINGIOMA; NEUROBLASTOMA; NEUROENDOCRINE TUMOR; NONHUMAN; OVARY CARCINOMA; PANCREAS CANCER; PHEOCHROMOCYTOMA; PROTEIN STRUCTURE; REVIEW; STOMACH CANCER; STOMACH TUMOR; SURVIVAL TIME; THYROID MEDULLARY CARCINOMA;

ANIMALS; GASTROINTESTINAL NEOPLASMS; HUMANS; PANCREATIC NEOPLASMS; RECEPTORS, CHOLECYSTOKININ;

EID: 34447250563     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802607780960492     Document Type: Review

References (85)

1. Rehfeld, J. F. Clinical endocrinology and metabolism. Cholecystokinin. Best Pract. Res. Clin. Endocrinol. Metab., 2004, 18, 569-586.
2. Dockray, G. J.; Varro, A.; Dimaline, R.; Wang, T. The gastrins: their production and biological activities. Annu. Rev. Physiol., 2001, 63, 119-139.
3. Rothman, S. S.; Wells, H. Enhancement of pancreatic enzyme synthesis by pancreozymin. Am. J. Physiol., 1967, 213, 215-218.
4. Crean, G. P.; Marshall, M. W.; Rumsey, R. D. Parietal cell hyperplasia induced by the administration of pentagastrin (ICI 50,123) to rats. Gastroenterology, 1969, 57, 147-155.
5. Jensen,. R. T. Involvement of cholecystokinin/gastrin-related peptides and their receptors in clinical gastrointestinal disorders. Pharmacol. Toxicol., 2002, 91, 333-350.
6. Aly, A.; Shulkes, A.; Baldwin, G. S. Gastrins, cholecystokinins and gastrointestinal cancer. Biochim. Biophys. Acta, 2004, 1704, 1-10.
7. Shulkes, A.; Baldwin, G. S. Biology of gut cholecystokinin and gastrin receptors. Clin. Exp. Pharmacol. Physiol., 1997, 24, 209-216.
8. Reubi, J. C.; Schaer, J. C.; Waser, B. Cholecystokinin(CCK)-A and CCK-B/ gastrin receptors in human tumors. Cancer Res., 1997, 57, 1377-1386.
9. Houghton, J.; Wang, T. C. Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers. Gastroenterology, 2005, 128, 1567-1578.
10. Wang, T. C.; Koh, T. J.; Varro, A.; Cahill, R. J.; Dangler, C. A. et al. Processing and proliferative effects of human progastrin in transgenic mice. J. Clin. Invest., 1996, 98, 1918-1929.
11. Koh, T. J.; Dockray, G. J.; Varro, A.; Cahill, R. J.; Dangler, C. A. et al. Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation. J. Clin. Invest., 1999, 103, 1119-1126.
12. Aly, A.; Shulkes, A.; Baldwin, G. S. Short term infusion of glycine-extended gastrin(17) stimulates both proliferation and formation of aberrant crypt foci in rat colonic mucosa. Int. J. Cancer, 2001, 94, 307-313.
13. Hollande, F.; Imdahl, A.; Mantamadiotis, T.; Ciccotosto, G. D.; Shulkes, A. et al. Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line. Gastroenterology, 1997, 113, 1576-1588.
14. Stepan, V. M.; Sawada, M.; Todisco, A.; Dickinson, C. J. Glycine-extended gastrin exerts growth-promoting effects on human colon cancer cells. Mol. Med., 1999, 5, 147-159.
15. Baldwin, G. S.; Hollande, F.; Yang, Z.; Karelina, Y.; Paterson, A. et al. Biologically active recombinant human progastrin(6-80) contains a tightly bound calcium ion. J. Biol. Chem., 2001, 276, 7791-7796.
16. Haigh, C. R.; Attwood, S. E.; Thompson, D. G.; Jankowski, J. A.; Kirton, C. M. et al. Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK2 receptor. Gastroenterology, 2003, 124, 615-625.
17. Abdalla, S. I.; Lao-Sirieix, P.; Novelli, M. R.; Lovat, L. B.; Sanderson, I. R. et al. Gastrin-induced cyclooxygenase-2 expression in Barrett's carcinogenesis. Clin. Cancer Res., 2004, 10, 4784-4792.
18. Moore, T. C.; Jepeal, L. I.; Boylan, M. O.; Singh, S. K.; Boyd, N. et al. Gastrin stimulates receptor-mediated proliferation of human esophageal adenocarcinoma cells. Regul. Pept., 2004, 120, 195-203.
19. Harris, J. C.; Clarke, P. A.; Awan, A.; Jankowski, J.; Watson, S. A. An antiapoptotic role for gastrin and the gastrin/CCK-2 receptor in Barrett's esophagus. Cancer Res., 2004, 64, 1915-1919.
20. Wang, T. C.; Dangler, C. A.; Chen, D.; Goldenring, J. R.; Koh, T. et al. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology, 2000, 118, 36-47.
21. Fox, J. G.; Wang, T. C.; Rogers, A. B.; Poutahidis, T.; Ge, Z. et al. Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology, 2003, 124, 1879-1890.
22. Fox, J. G.; Rogers, A. B.; Ihrig, M.; Taylor, N. S.; Whary, M. T. et al. Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific. Cancer Res., 2003, 63, 942-950.
23. Takaishi, S.; Cui, G.; Frederick, D. M.; Carlson, J. E.; Houghton, J. et al. Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer. Gastroenterology, 2005, 128, 1965-1983.
24. Zavros, Y.; Eaton, K. A.; Kang, W.; Rathinavelu, S.; Katukuri, V. et al. Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma. Oncogene, 2005, 24, 2354-2366.
25. Merchant, J. L. Inflammation, atrophy, gastric cancer: connecting the molecular dots. Gastroenterology, 2005, 129, 1079-1082.
26. Reubi, J. C.; Waser, B.; Schmassmann, A.; Laissue, J. A. Receptor autoradiographic evaluation of cholecystokinin, neurotensin, somatostatin and vasoactive intestinal peptide receptors in gastrointestinal adenocarcinoma samples: where are they really located? Int. J. Cancer, 1999, 81, 376-396.
27. Kulaksiz, H.; Arnold, R.; Goke, B.; Maronde, E.; Meyer, M. et al. Expression and cell-specific localization of the cholecystokinin B/ gastrin receptor in the human stomach. Cell Tissue Res., 2000, 299, 289-298.
28. Schmitz, F.; Goke, M. N.; Otte, J. M.; Schrader, H.; Reimann, B. et al. Cellular expression of CCK-A and CCK-B/gastrin receptors in human gastric mucosa. Regul. Pept., 2001, 102, 101-110.
29. Tommeras, K.; Bakke, I.; Sandvik, A. K.; Larsson, E.; Waldum, H. L. Rat parietal cells express CCK(2) receptor mRNA: gene expression analysis of single cells isolated by laser-assisted microdissection. Biochem. Biophys. Res. Commun., 2002, 297, 335-340.
30. Hakanson, R.; Ding, X. Q.; Norlen, P.; Lindstrom, E. CCK2 receptor antagonists: pharmacological tools to study the gastrin-ECL cell-parietal cell axis. Regul. Pept., 1999, 80, 1-12.
31. Friis-Hansen, L.; Sundler, F.; Li, Y.; Gillespie, P. J.; Saunders, T. L. et al. Impaired gastric acid secretion in gastrin-deficient mice. Am. J. Physiol., 1998, 274, G561-568.
32. Chen, D.; Zhao, C. M.; Al-Haider, W.; Hakanson, R.; Rehfeld, J. F. et al. Differentiation of gastric ECL cells is altered in CCK(2) receptor-deficient mice. Gastroenterology, 2002, 123, 577-585.
33. Hakanson, R.; Tielemans, Y.; Chen, D.; Andersson, K.; Mattsson, H. et al. Time-dependent changes in enterochromaffin-like cell kinetics in stomach of hypergastrinemic rats. Gastroenterology, 1993, 105, 15-21.
34. Peghini, P. L.; Annibale, B.; Azzoni, C.; Milione, M.; Corleto, V. D. et al. Effect of chronic hypergastrinemia on human enterochromaffin-like cells: insights from patients with sporadic gastrinomas. Gastroenterology, 2002, 123, 68-85.
35. Rindi, G.; Bordi C.; Rappel, S.; La Rosa, S.; Stolte, M. et al. Gastric carcinoids and neuroendocrine carcinomas: pathogenesis, pathology, and behavior. World J. Surg., 1996 20, 168-172.
36. Baldwin, G. S. The role of gastrin and cholecystokinin in normal and neoplastic gastrointestinal growth. J. Gastroenterol. Hepatol., 1995, 10, 215-232.
37. Bierkamp, C.; Bonhoure, S.; Mathieu, A.; Clerc, P.; Fourmy, D. et al. Expression of cholecystokinin-2/gastrin receptor in the murine pancreas modulates cell adhesion and cell differentiation in vivo. Am. J. Pathol., 2004, 165, 2135-2145.
38. Mathieu, A.; Clerc, P.; Portolan, G.; Bierkamp, C.; Lulka, H. et al. Transgenic expression of CCK2 receptors sensitizes murine pancreatic acinar cells to carcinogen-induced preneoplastic lesions formation. Int. J. Cancer, 2005, 115, 46-54.
39. Clerc, P.; Leung-Theung-Long, S.; Wang, T. C.; Dockray, G. J.; Bouisson, M. et al. Expression of CCK2 receptors in the murine pancreas: proliferation, transdifferentiation of acinar cells, and neoplasia. Gastroenterology, 2002, 122, 428-437.
40. Prasad, N. B.; Biankin, A. V.; Fukushima, N.; Maitra, A.; Dhara, S. et al. Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. Cancer Res., 2005, 65, 1619-1626.
41. Goetze, J. P.; Nielsen, F. C.; Burcharth, F.; Rehfeld, J. F. Closing the gastrin loop in pancreatic carcinoma: coexpression of gastrin and its receptor in solid human pancreatic adenocarcinoma. Cancer, 2000, 88, 2487-2494.
42. Weinberg, D. S.; Ruggeri, B.; Barber, M. T.; Biswas, S.; Miknyocki, S. et al. Cholecystokinin A and B receptors are difterentially expressed in normal pancreas and pancreatic adenocarcinoma. J. Clin. Invest., 1997, 100, 597-603.
43. Tang, C.; Biemond, I.; Offerhaus, G. J.; Verspaget, W.; Lamers, C. B. Expression of receptors for gut peptides in human pancreatic adenocarcinoma and tumour-free pancreas. Br J. Cancer, 1997, 75, 1467-1473.
44. Reubi, J. C.; Waser, B.; Gugger, M.; Friess, H.; Kleeff, J. et al. Distribution of CCK1 and CCK2 receptors in normal and diseased human pancreatic tissue. Gastroenterology, 2003, 125, 98-106.
45. Upp, J. R., Jr.; Singh, P.; Townsend, C. M., Jr.; Thompson, J. C. Clinical significance of gastrin receptors in human colon cancers. Cancer Res., 1989, 49, 488-492.
46. Matsushima, Y.; Kinoshita, Y.; Nakata, H.; Inomoto-Naribayashi, Y.; Asahara, M. et al. Gastrin receptor gene expression in several human carcinomas. Jpn. J. Cancer Res., 1994, 85, 819-824.
47. Brinton, L. A.; Gridley, G.; Hrubec, Z.; Hoover, R.; Fraumeni, J. F., Jr. Cancer risk following pernicious anaemia. Br. J. Cancer, 1989, 59, 810-813.
48. Sobhani, I.; Lehy, T.; Laurent-Puig, P.; Cadiot, G.; Ruszniewski, P. et al. Chronic endogenous hypergastrinemia in humans: evidence for a mitogenic effect on the colonic mucosa. Gastroenterology, 1993, 105, 22-30.
49. Cobb, S.; Wood, T.; Tessarollo, L.; Velasco, M.; Given, R. et al. Deletion of functional gastrin gene markedly increases colon carcinogenesis in response to azoxymethane in mice. Gastroenterology, 2002, 123, 516-530.
50. Muerkoster, S.; Isberner, A.; Arlt, A.; Witt, M.; Reimann, B. et al. Gastrin suppresses growth of CCK2 receptor expressing colon cancer cells by inducing apoptosis in vitro and in vivo. Gastroenterology, 2005, 129, 952-968.
51. Ciccotosto, G. D.; McLeish, A.; Hardy, K. J.; Shulkes, A. Expression, processing, and secretion of gastrin in patients with colorectal carcinoma. Gastroenterology, 1995, 109, 1142-1153.
52. Siddheshwar, R. K.; Gray, J. C.; Kelly, S. B. Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma. Gut, 2001, 48, 47-52.
53. Baldwin, G. S.; Shulkes, A. Gastrin, gastrin receptors and colorectal carcinoma. Gut, 1998, 42, 581-584.
54. Smith, A. M.; Watson, S. A. Review article: gastrin and colorectal cancer. Aliment. Pharmacol. Ther., 2000, 14, 1231-1247.
55. Reubi, J. C.; Waser, B. Unexpected high incidence of cholecystokinin-B/ gastrin receptors in human medullary thyroid carcinomas. Int. J. Cancer, 1996, 67, 644-647.
56. Reubi, J. C.; Zimmermann, A.; Jonas, S.; Waser, B.; Neuhaus, P. et al. Regulatory peptide receptors in human hepatocellular carcinomas. Gut, 1999, 45, 766-774.
57. Schulz, S.; Rocken, C.; Mawrin, C. Immunohistochemical localization of CCK1 cholecystokinin receptors in normal and neoplastic human tissues. J. Clin. Endocrinol. Metab., 2005, 90, 6149-6155.
58. Lefranc, F.; Chaboteaux, C.; Belot, N.; Brotchi, J.; Salmon, I. et al. Determination of RNA expression for cholecystokinin/gastrin receptors (CCKA, CCKB and CCKC) in human tumors of the central and peripheral nervous system. Int. J. Oncol., 2003, 22, 213-219.
59. Blaker, M.; de Weerth, A.; Tometten, M.; Schulz, M.; Hoppner, W. et al. Expression of the cholecystokinin 2-receptor in normal human thyroid gland and medullary thyroid carcinoma. Eur. J. Endocrinol., 2002, 146, 89-96.
60. Lignon, M. F.; Bernad, N.; Martinez, J. Pharmacological characterization of type B cholecystokinin binding sites on the human JURKAT T lymphocyte cell line. Mol. Pharmacol., 1991, 39, 615-620.
61. Lignon, M. F.; Bernad, N.; Martinez, J. Cholecystokinin increases intracellular Ca2+ concentration in the Human JURKAT T Lymphocyte cell line. Eur. J. Pharmacol., 1993, 245, 241-246.
62. Iwata, N.; Murayama, T.; Matsumori, Y.; Ito, M.; Nagata, A. et al. Autocrine loop through cholecystokinin-B/gastrin receptors involved in growth of human leukemia cells. Blood, 1996, 88, 2683-2689.
63. Stubbs, M.; Khan, K.; Wickremasinghe, R. G.; Ganeshaguru, K.; Caplin, M. E. CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines. Oncol. Rep., 2005, 14, 1055-1058.
64. Behr, T. M.; Behe, M. P. Cholecystokinin-B/Gastrin receptor-targeting peptides for staging and therapy of medullary thyroid cancer and other cholecystokinin-B receptor-expressing malignancies. Semin. Nucl. Med., 2002, 32, 97-109.
65. Laverman, P.; Behe, M.; Oyen, W. J.; Willems, P. H.; Corstens, F. H. et al. Two technetium-99m-labeled cholecystokinin-8 (CCK8) peptides for scintigraphic imaging of CCK receptors. Bioconjug. Chem., 2004, 15, 561-568.
66. Nock, B. A.; Maina, T.; Behe, M.; Nikolopoulou, A.; Gotthardt, M. et al. CCK-2/gastrin receptor-targeted tumor imaging with (99m)Tc-labeled minigastrin analogs. J. Nucl. Med., 2005, 46, 1727-1736.
67. Watson, S. A.; Gilliam, A. D. G17DT-a new weapon in the therapeutic armoury for gastrointestinal malignancy. Expert Opin. Biol. Ther., 2001, 1, 309-317.
68. Gilliam, A. D.; Watson, S. A.; Henwood, M.; McKenzie, A. J.; Humphreys, J. E. et al. A phase II study of G17DT in gastric carcinoma. Eur. J. Surg. Oncol., 2004, 30, 536-543.
69. Brett, B. T.; Smith, S. C.; Bouvier, C. V.; Michaeli, D.; Hochhauser, D. et al. Phase II study of anti-gastrin-17 antibodies, raised to G17DT, in advanced pancreatic cancer. J. Clin. Oncol., 2002, 20, 4225-4231.
70. Ajani, J. A.; Randolph Hecht, J.; Ho, L.; Baker, J.; Oortgiesen, M. et al. An open-label, multinational, multicenter study of G17DT vaccination combined with cisplatin and 5-fluorouracil in patients with untreated, advanced gastric or gastroesophageal cancer: The GC4 study. Cancer, 2006.
71. Harrison, J. D.; Jones, J. A.; Morris, D. L. The effect of the gastrin receptor antagonist proglumide on survival in gastric carcinoma. Cancer, 1990, 66, 1449-1452.
72. Chen, Y. P.; Yang, J. S.; Liu, D. T.; Yang, W. P. Long-term effects of proglumide on resection of cardiac adenocarcinoma. World J. Gastroenterol., 2005, 11, 2549-2551.
73. Abbruzzese, J. L.; Gholson, C. F.; Daugherty, K.; Larson, E.; DuBrow, R. et al. A pilot clinical trial of the cholecystokinin receptor antagonist MK-329 in patients with advanced pancreatic cancer. Pancreas, 1992, 7, 165-171.
74. Militello, C.; Sperti, C.; Di Prima, F.; Pedrazzoli, S. Clinical evaluation and safety of loxiglumide (CCK-A receptor antagonist) in nonresectable pancreatic cancer patients. Italian Pancreatic Cancer Study Group. Pancreas, 1997, 14, 222-228.
75. Clerc, P.; Dufresne, M.; Saillan, C.; Chastre, E.; Andre, T. et al. Differential expression of the CCK-A and CCK-B/gastrin receptor genes in human cancers of the esophagus, stomach and colon. Int. J. Cancer, 1997, 72, 931-936.
76. Okada, N.; Kubota, A.; Imamura, T.; Suwa, H.; Kawaguchi, Y. et al. Evaluation of cholecystokinin, gastrin, CCK-A receptor, and CCK-B/ gastrin receptor gene expressions in gastric cancer. Cancer Lett., 1996, 106, 257-262.
77. Henwood, M.; Clarke, P. A.; Smith, A. M.; Watson, S. A. Expression of gastrin in developing gastric adenocarcinoma. Br. J. Surg., 2001, 88, 564-568.
78. Zhou, J. J.; Chen, M. L.; Zhang, Q. Z.; Hu, J. K.; Wang, W. L. Coexpression of cholecystikinin-B/gastrin receptor and gastrin gene in human gastric tissues and gastric cancer cell line. World J. Gastroenterol., 2004, 10, 791-794.
79. Lee, H. K.; Lee, H. J.; Hur, K.; Lee, H. S.; Kim, W. H. et al. Growth effect of gastrin on gastric cancer and its clinical implications for gastric cancer surgery. Oncol. Rep., 2005, 14, 383-388.
80. Hur, K.; Kwak, M. K.; Lee, H. J.; Park do, J.; Lee, H. K. et al. Expression of gastrin and its receptor in human gastric cancer tissues. J. Cancer Res. Clin. Oncol., 2006, 132, 85-91.
81. Moonka, R.; Zhou, W.; Bell, R. H., Jr. Cholecystokinin-A receptor messenger RNA expression in human pancreatic cancer. J. Gastrointest. Surg., 1999, 3, 134-140.
82. Caplin, M.; Savage, K.; Khan, K.; Brett, B.; Rode, J. et al. Expression and processing of gastrin in pancreatic adenocarcinoma. Br. J. Surg., 2000, 87, 1035-1040.
83. Imdahl A.; Mantamadiotis, T.; Eggstein, S.; Farthmann, E. H.; Baldwin, G. S. Expression of gastrin, gastrin/CCK-B and gastrin/CCK-C receptors in human colorectal carcinomas. J. Cancer Res. Clin. Oncol., 1995, 121, 661-666.
84. Biagini, P.; Monges, G.; Vuaroqueaux, V.; Parriaux, D.; Cantaloube, J. F. et al. The human gastrin/cholecystokinin receptors: type B and type C expression in colonic tumors and cell lines. Life Sci., 1997, 61, 1009-1018.
85. Schmitz, F.; Otte, J. M.; Stechele, H. U.; Reimann, B.; Banasiewicz, T. et al. CCK-B/gastrin receptors in human colorectal cancer. Eur. J. Clin. Invest., 2001, 31, 812-820.