Expression of receptors for gut peptides in human pancreatic adenocarcinoma and tumour-free pancreas

British Journal of Cancer

Volumn 75, Issue 10, 1997, Pages 1467-1473

  Tang, C ^a   Biemond, I ^a   Offerhaus, G J A ^b   Verspaget, W ^a   Lamers, C B H W ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Gut peptide; Pancreatic cancer; Receptor

Indexed keywords

GASTROINTESTINAL HORMONE; GASTROINTESTINAL POLYPEPTIDE; RECEPTOR; SECRETIN;

ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0030975685     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.251     Document Type: Article

References (55)

1. Abbruzzese JL, Gholson CF, Daugherty K, Larson E, Dubrow R, Berlin R and Levin B (1992) A pilot clinical trial of the cholecystokinin receptor antagonist MK-329 in patients with advanced pancreatic cancer. Pancreas 7: 165-171
2. Adamou JE, Aiyar N, Van Horn S and Elshourbagy NA (1995) Cloning and functional characterization of the human vasoactive intestinal peptide (VIP)-2 receptor. Biochem Biophys Res Commun 209: 385-392
3. Alexander RW, Upp JR Jr, Poston GJ, Townsend CM Jr, Singh P and Thompon JC (1988) Bombesin inhibits growth of human pancreatic adenocarcinoma in nude mice. Pancreas 3: 297-302
4. Bell RH Jr, Kuhlmann ET, Jenson RT and Longnecker DS (1992) Overexpression of cholecystokinin receptors in azaserine-induced neoplasms of the rat pancreas. Cancer Res 52: 3295-3299
5. Cantor P, Olsen O, Gertz BJ, Gjorup T and Worning H (1991) Inhibition of cholecystokinin-stimulated pancreaticobiliary output in man by the cholecystokinin receptor antagonist MK-329. Scand J Gastroenterol 26: 627-637
6. Chey WY (1995) Neurohumoral control of the exocrine pancreas. Current Opin Gastroenterol 11: 389-396
7. Domschke S, Domschke W, Rosch W, Konturek SJ, Sprugel W, Mitznegg P, Wunsch F and Demling I (1977) Vasoactive intestinal peptide: a secretin-like partial agonist for pancreatic secretion in man. Gastroenterology 73: 478-480
8. Douglas BR, Woutersen RA, Jansen JBMJ, De Jong AJL, Rovati LC and Lamers CBHW (1989) Influence of cholecystokinin antagonist on the effects of cholecystokinin and bombesin on azaserine-induced lesions in rat pancreas. Gastroenterology 96: 426-429
9. Edwards BF, Redding TW and Schally AV (1989) The effect of gastrointestinal hormones on the incorporation of tritiated thymidine in the pancreatic adenocarcinoma cell line (WD PaCa). Int J Pancreatol 5: 191-201
10. Ensinck JW, Laschansky EC, Vogel RE, Simonowitz DA, Roos BA and Francis BH (1989) Circulating prosomatostatin-derived peptides. Differential responses to food ingestion. J Clin Invest 83: 1580-1589
11. Estival A, Clemente F and Ribet A (1981) Adenocarcinoma of the human exocrine pancreas: presence of secretin and caerulein receptors. Biochem Biophys Res Commun 102: 1336-1341
12. Estival A, Mouniélou P, Trocheris V, Scemama JL, Clemente F, Hollande E and Ribet A (1983) Presence of VIP receptors in a human pancreatic adenocarcinoma cell line. Modulation of the cAMP response during cell proliferation. Biochem Biophys Res Commun 111: 958-963
13. Fahrenkrug J, Pedersen JH, Yamashita Y, Ottesen B, Hökfelt T and Lundberg JM (1987) Occurrence of VIP and peptide HM in human pancreas and their influence on pancreatic endocrine secretion in man. Regul Pept 18: 51-61
14. Fourmy D, Zahidi A, Fabre R, Guidet M, Pradayrol L and Ribet A (1987) Receptors for cholecystokinin and gastrin peptides display specific binding properties and are structurally different in guinea-pig and dog pancreas. Eur J Biochem 165: 683-692
15. Herrington MK and Adrian TE (1995) On the role of CCK in pancreatic cancer. Int J Panceatol 17: 121-138
16. Howatson AG and Carter DC (1985) Pancreatic carcinogenesis - enhancement by cholecystokinin in the hamster-nitrosamine model. Br J Cancer 51: 107-114
17. Jiang S and Ulrich C (1995) Molecular cloning and functional expression of a human pancreatic secretin receptor. Biochem Biophys Res Commun 207: 883-890
18. Johnson FE, Laregina MC, Martin SA and Bashiti HM (1983) Cholecystokinin inhibits pancreatic and hepatic carcinogenesis. Cancer Detec Prev 6: 389-402
19. Kumamoto T, Sumii K, Haruma K, Tari A, Tanaka K and Kajiyama G (1989) Gastrin receptors in the human gastrointestinal tract and pancreas. Gastroenterol Jpn 24: 109-114
20. Laburthe M, Couvineau A, Amiranoff B and Voisin T (1994) Receptors for gut regulatory peptides. Baillière's Clin Endocrinol Metab 8: 77-110
21. Liehr R, Melnykovych G and Solomon TE (1990) Growth effects of regulatory peptides on human pancreatic cancer lines PANC-1 and MIA PaCa-2. Gastroenterology 98: 1666-1674
22. Longnecker DS (1991) Hormones and pancreatic cancer. Int J Pancreatol 9: 81-86
23. Longnecker DS (1993) Experimental models of exocrine pancreatic tumours. In The Pancreas: Biology, Pathobiology, and Disease, Go VLW, (ed.), pp. 551-564. Raven Press: New York
24. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275
25. Malesci A, Defazio C, Festorazzi S, Bonato C, Vallentini A, Tacconi M, Rovati LC and Setnikar I (1990) Effect of loxiglumide on gallbladder contractile response to caerulein and food in humans. Gastroenterology 98: 1307-1310
26. Marongiu L, Perra MT, Pinna AD, Sirigu F and Sirigu P (1993) Peptidergic (VIP) nerves in normal human pancreas and in pancreatitis: an immunohistochemical study. Histol Histopathol 8: 127-132
27. Meijers M, Van Garderen-Hoetmer A, Lamers CBHW, Rovati LC, Jansen JBMJ and Woutersen RA (1990) Role of cholecystokinin in the development of BOP-induced pancreatic lesions in hamsters. Carcinogenesis 11: 2223-2226
28. Meijers M, Van Garderen-Hoetmer A, Lamers CBHW, Rovati LC, Jansen JBMJ and Woutersen RA (1991) Effects of bombesin on the development of N-nitrosobis (2-oxopropyl)amine-induced pancreatic lesions in hamsters. Cancer Lett 59: 45-50
29. Meijers M, Woutersen RA, Van Garderen-Hoetmer A, Bakker GH, De Jong FH, Foekens JA and Klijn JGM (1992) Effects of sandostatin and castration on pancreatic carcinogenesis in rats and hamsters. Int J Cancer 50: 246-251
30. Meuth VL, Philouze-Rome V, Huerou-Luron IL, Formal M, Vaysse N, Gespach C, Guilloteau P and Fourmy D (1993) Differential expression of A- and B-subtypes of cholecystokinin/gastrin receptors in the developing calf pancreas. Endocrinology 133: 1182-1191
31. Munson PJ and Rodbard D (1980) LIGAND: a versatile, computerized approach for characterization of ligand-binding systems. Anal Biochem 107: 220-229
32. Nio Y, Tsubono M, Morimoto H, Kawabata K, Masai Y, Hayashi H, Manabe T, Imamura M and Fukumoto M (1993) Loxiglumide (CR 1505), a cholecystokinin antagonist, specifically inhibits the growth of human pancreatic cancer lines xenografted into nude mice. Cancer 72: 3599-3606
33. Poston GJ, Yao CZ, Upp JR Jr, Alexander RW, Townsend CM Jr and Thompson JC (1988) Vasoactive intestinal peptide inhibits the growth of hamster pancreatic cancer but not human pancreatic cancer in vivo. Pancreas 3: 439-443
34. Poston GJ, Gillespie J and Guillou PJ (1991) Biology of pancreatic cancer. Gut 32: 800-812
35. Qin Y, Ertl T, Cai R, Halmos G and Schally AV (1994) Inhibitory effect of bombesin receptor antagonist RC-3095 on the growth of human pancreatic cancer cells in vivo and in vitro. Cancer Res 54: 1035-1041
36. Robberecht P, De Neef P, Waelbroeck M, Camus J-C, Scemama J-L, Fourmy D, Pradayrol L, Vaysse N and Christophe J (1988) Secretin receptors in human pancreatic membranes. Pancreas 3: 529-535
37. Sankaran H, Goldfine ID, Deveney CW, Wong K and Williams JA (1980) Binding of cholecystokinin to high affinity receptors on isolated rat pancreatic acini. J Biol Chem 255: 1849-1853
38. 4-bombesin with specific receptors on normal human pancreatic membranes. Regul Pept 13: 125-132
39. 125I-labelled synthetic porcine secretin for radioimmunoassay. Scand J Clin Lab Invest 36: 661-668
40. Schrenck TV, Moran TH, Heinz-Erian P, Gardner JD and Jensen RT (1988) Cholecystokinin receptors on gallbladder muscle and pancreatic acinar cells: a comparative study. Am J Physiol 255: G512-521
41. Silvente-Poirot S, Dufresne M, Vaysse N and Fourmy D (1993) The peripheral cholecystokinin receptors. Eur J Biochem 215: 513-529
42. Singh P, Townsend CM, Poston GJ and Reubi J-C (1991) Specific binding of cholecystokinin, estradiol and somatostatin to human pancreatic cancer xenografts. J Steroid Biochem Mol Biol 39: 759-767
43. Smith JP, Solomon TE, Bagheri S and Kramer S (1990) Cholecystokinin stimulates growth of human pancreatic adenocarcinoma SW-1990. Dig Dis Sci 35: 1377-1384
44. Smith JP, Kramer ST and Solomon TH (1991) CCK stimulates growth of six human pancreatic cancer cell lines in serum-free medium. Regul Pept 32: 341-349
45. Smith JP, Liu G, Soundararajan V, McLaughlin PJ and Zagon IS (1994) Identification and characterization of CCK-B/gastrin receptors in human pancreatic cancer cell lines. Am J Physiol 266: R277-R283
46. Tang C, Biemond I, Appel MJ, Visser CJT, Woutersen RA and Lamers CBHW (1995a) Gut peptide receptors in pancreata of azaserine-treated and normal control rats. Carcinogenesis 16: 2951-2956
47. Tang C, Biemond I and Lamers CBHW (1995b) Localization and quantification of cholecystokinin receptors in rat brain with storage phosphor autoradiography. Biotechniques 18: 886-889
48. Tang C, Biemond I, Appel MJ, Visser CJT, Woutersen RA and Lamers CBHW (1996) Expression of receptors for gut peptides in pancreata of BOP-treated and control hamsters. Carcinogenesis 17: 2171-2175
49. Townsend CM Jr, Franklin RB, Watson LC, Glass EJ and Thompson JC (1981) Stimulation of pancreatic cancer growth by caerulein and secretin. Surg Forum 32: 228-229
50. Upp JR, Singh P, Townsend CM and Thompson JC (1987) Predicting response to endocrine therapy in human pancreatic cancer with cholecystokinin receptors. Gatroenterology 92: 1677
51. Virgolini I, Raderer M, Kurtaran A, Angelberger P, Banyai S, Yang Q, Li S, Banyai M, Pidlich J, Niederle B, Scheithauer W and Valent P (1994) Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumours. N Engl J Med 331: 1116-1121
52. Wank SA, Pisegna JR and De Weerth A (1994) Cholecystokinin receptor family. Molecular cloning, structure, and functional expression in rat, guinea pig, and human. Ann NY Acad Sci 713: 49-66
53. Williams JA, Bailey AC and Roach E (1988) Temperature dependence of high-affinity CCK receptor binding and CCK internalization in rat pancreatic acini. Am J Physiol 254: G513-521
54. Yu D-H, Noguchi M, Zhou Z-C, Villanueva ML, Gardner JD and Jensen RT (1987) Characterization of gastrin receptors on guinea pig pancreatic acini. Am J Physiol 253: G793-801
55. Yu D-H, Huang SC, Wank SA, Mantey S, Gardner JD and Jensen RT (1990) Pancreatic receptors for cholecystokinin: evidence for three receptor classes. Am J Physiol 258: G86-95