Human granulocytic anaplasmosis and macrophage activation

Clinical Infectious Diseases

Volumn 45, Issue 2, 2007, Pages 199-204

  Dumler, J Stephen ^a   Barat, Nicole C ^a   Barat, Christopher E ^b   Bakken, Johan S ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STEVENSON UNIVERSITY   (United States)

^c St Luke's Infectious Disease Associates   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; FERRITIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; TRIACYLGLYCEROL; BACTERIAL DNA; BIOLOGICAL MARKER; CYTOKINE;

ADULT; AGED; ANAPLASMA PHAGOCYTOPHILUM; ANAPLASMOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DISEASE SEVERITY; FEMALE; FERRITIN BLOOD LEVEL; FEVER; HISTOPATHOLOGY; HUMAN; IMMUNOPATHOGENESIS; LEUKOPENIA; MACROPHAGE ACTIVATION; MALE; PRIORITY JOURNAL; THROMBOCYTOPENIA; TISSUE INJURY; TRIACYLGLYCEROL BLOOD LEVEL; ADOLESCENT; AGE DISTRIBUTION; BLOOD; CASE CONTROL STUDY; FOLLOW UP; HOSPITALIZATION; INCIDENCE; ISOLATION AND PURIFICATION; METHODOLOGY; MIDDLE AGED; NONPARAMETRIC TEST; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PROBABILITY; REFERENCE VALUE; RISK ASSESSMENT; SEX RATIO;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; ANAPLASMA PHAGOCYTOPHILUM; ANAPLASMOSIS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CYTOKINES; DNA, BACTERIAL; FEMALE; FERRITINS; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; MACROPHAGE ACTIVATION; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROBABILITY; REFERENCE VALUES; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SEX DISTRIBUTION; STATISTICS, NONPARAMETRIC; TRIGLYCERIDES;

EID: 34447092631     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/518834     Document Type: Article

References (22)

1. Dumler JS, Choi KS, Garcia-Garcia JC, et al. Human granulocytic anaplasmosis and Anaplasma phagocytophilum. Emerg Infect Dis 2005; 11:1828-34.
2. Bakken JS, Dumler JS. Human granulocytic ehrlichiosis. Clin Infect Dis 2000; 31:554-60.
3. Demma LJ, Holman RC, McQuiston JH, Krebs JW, Swerdlow DL. Epidemiology of human ehrlichiosis and anaplasmosis in the United States, 2001-2002. Am J Trop Med Hyg 2005; 73:400-9.
4. Carlyon JA, Fikrig E. Mechanisms of evasion of neutrophil killing by Anaplasma phagocytophilum. Curr Opin Hematol 2006; 13:28-33.
5. Martin ME, Caspersen K, Dumler JS. Immunopathology and ehrlichial propagation are regulated by interferon-γ and interleukin-10 in a murine model of human granulocytic ehrlichiosis. Am J Pathol 2001; 158:1881-8.
6. Dumler JS, Trigiani ER, Bakken JS, Aguero-Rosenfeld ME, Wormser GP. Serum cytokine responses during acute human granulocytic ehrlichiosis. Clin Diagn Lab Immunol 2000; 7:6-8.
7. Lepidi H, Bunnell JE, Martin ME, Madigan JE, Stuen S, Dumler JS. Comparative pathology, and immunohistology associated with clinical illness after Ehrlichia phagocytophila-group infections. Am J Trop Med Hyg 2000; 62:29-37.
8. Choi KS, Scorpio DG, Barat NC, Dumler JS. Msp2 variation in Anaplasma phagocytophilum in vivo does not stimulate T cell immune responses or interferon-gamma production. FEMS Immunol Med Microbiol 2007; 49:374-86.
9. Choi KS, Webb T, Oelke M, Scorpio DG, Dumler JS. Differential innate immune cell activation and proinflammatory response in A. phagocytophilum infection. Infect Immun 2007; 75:3124-30.
10. Browning MD, Garyu JW, Dumler JS, Scorpio DG. Role of reactive nitrogen species in development of hepatic injury in a C57bl/6 mouse model of human granulocytic anaplasmosis. Comp Med 2006; 56:55-62.
11. Scorpio DG, Von Loewenich FD, Bogdan C, Dumler JS. Innate immune tissue injury and murine HGA: tissue injury in the murine model of granulocytic anaplasmosis relates to host innate immune response and not pathogen load. Ann N Y Acad Sci 2005; 1063:425-8.
12. Scorpio DG, von Loewenich FD, Gobel H, Bogdan C, Dumler JS. Innate immune response to Anaplasma phagocytophilum contributes to hepatic injury. Clin Vaccine Immunol 2006; 13:806-9.
13. Bakken JS, Aguero-Rosenfeld ME, Tilden RL, et al. Serial measurements of hematologic counts during the active phase of human granulocytic ehrlichiosis. Clin Infect Dis 2001; 32:862-70.
14. Lin M, Rikihisa Y. Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival. Infect Immun 2003; 71:5324-31.
15. Menasche G, Feldmann J, Fischer A, de Saint Basile G. Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis. Immunol Rev 2005; 203:165-79.
16. Grom AA. Natural killer cell dysfunction: a common pathway in systemic-onset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis? Arthritis Rheum 2004; 50:689-98.
17. Jordan MB, Hildeman D, Kappler J, Marrack P. An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood 2004; 104:735-43.
18. + Th1 cells contribute to toxic shock-like syndrome in an animal model of fatal monocytotropic ehrlichiosis. J Immunol 2004; 172:1786-800.
19. Walker DH, Dumler JS. Human monocytic and granulocytic ehrlichioses. Discovery and diagnosis of emerging tick-borne infections and the critical role of the pathologist. Arch Pathol Lab Med 1997; 121:785-91.
20. Janka G, zur Stadt U. Familial and acquired hemophagocytic lymphohistiocytosis. Hematology Am Soc Hematol Educ Program 2005; 2005:82-8.
21. Emmenegger U, Schaer DJ, Larroche C, Neftel KA. Haemophagocytic syndromes in adults: current concepts and challenges ahead. Swiss Med Wkly 2005; 135:299-314.
22. Mattner J, Debord KL, Ismail N, et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 2005; 434:525-9.