Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B

Cancer Research

Volumn 64, Issue 15, 2004, Pages 5212-5224

  Basile, John R ^a   Barac, Ana ^a   Zhu, Tianqing ^b   Guan, Kun Liang ^b   Gutkind, J Silvio ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; PLEXIN; PLEXIN B; PLEXIN B1; PROTEIN TYROSINE KINASE; RHO FACTOR; RHO KINASE; SEMAPHORIN; SEMAPHORIN 4D; SEMAPHORIN CLASS IV; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANGIOGENESIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL SURFACE; CHIMERA; CONTROLLED STUDY; DRUG EFFECT; GENE DELIVERY SYSTEM; HUMAN; HUMAN CELL; LENTIVIRINAE; NERVE CELL DIFFERENTIATION; NERVE FIBER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN SECRETION; SEQUENCE HOMOLOGY;

ANTIGENS, CD; CELL MOVEMENT; CELLS, CULTURED; CHEMOTAXIS; ENDOTHELIUM, VASCULAR; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; LENTIVIRUS; MEMBRANE GLYCOPROTEINS; NEOVASCULARIZATION, PHYSIOLOGIC; NERVE TISSUE PROTEINS; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-MET; RECEPTORS, CELL SURFACE; RECEPTORS, GLUTAMATE; RECOMBINANT FUSION PROTEINS; RHO GTP-BINDING PROTEINS; SEMAPHORINS; SIGNAL TRANSDUCTION;

EID: 3442897353     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-0126     Document Type: Article

References (58)

1. Kolodkin AL, Matthes DJ, Goodman CS. The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. Cell 1993;75:1389-99.
2. He Z, Wang KC, Koprivica V, Ming G, Song HJ. Knowing how to navigate: mechanisms of semaphorin signaling in the nervous system. Sci STKE 2002;2002:RE1.
3. Raper JA. Semaphores and their receptors in vertebrates and invertebrates. Curr Opin Neurobiol 2000;10:88-94.
4. Ohta K, Mizutani A, Kawakami A, et al. Plexin: a novel neuronal cell surface molecule that mediates cell adhesion via a homophilic binding mechanism in the presence of calcium ions. Neuron 1995;14:1189-99.
5. Tamagnone L, Artigiani S, Chen H, et al. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell 1999;99:71-80.
6. Tamagnone L, Comoglio PM. Signalling by semaphorin receptors: cell guidance and beyond. Trends Cell Biol 2000;10:377-83.
7. Trusolino L, Comoglio PM. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nat Rev Cancer 2002;2:289-300.
8. Bismuth G, Boumsell L. Controlling the immune system through semaphorins. Sci STKE 2002;2002:RE4.
9. Chen H, He Z, Bagri A, Tessier-Lavigne M. Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins. Neuron 1998;21:1283-90.
10. Kolodkin AL, Levengood DV, Rowe EG, et al. Neuropilin is a semaphorin III receptor. Cell 1997;90:753-62.
11. Takahashi T, Fournier A, Nakamura F, et al. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell 1999;99:59-69.
12. Kawakami A, Kitsukawa T, Takagi S, Fujisawa H. Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system. J Neurobiol 1996;29:1-17.
13. Fujisawa H, Kitsukawa T, Kawakami A, et al. Roles of a neuronal cell-surface molecule, neuropilin, in nerve fiber fasciculation and guidance. Cell Tissue Res 1997;290:465-70.
14. Neufeld G, Cohen T, Shraga N, et al. The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis. Trends Cardiovasc Med 2002;12:13-9.
15. Serini G, Valdembri D, Zanivan S, et al. Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function. Nature (Lond) 2003;424:391-7.
16. Shoji W, Isogai S, Sato-Maeda M, Obinata M, Kuwada JY. Semaphorin3a1 regulates angioblast migration and vascular development in zebrafish embryos. Development (Camb) 2003;130:3227-36.
17. Bates D, Taylor GI, Minichiello J, et al. Neurovascular congruence results from a shared patterning mechanism that utilizes Semaphorin3A and Neuropilin-1. Dev Biol 2003;255:77-98.
18. Comoglio PM, Boccaccio C. The HGF receptor family: unconventional signal transducers for invasive cell growth. Genes Cells 1996;1:347-54.
19. Bottaro DP, Rubin JS, Faletto DL, et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science (Wash DC) 1991;251:802-4.
20. Maina F, Hilton MC, Andres R, et al. Multiple roles for hepatocyte growth factor in sympathetic neuron development. Neuron 1998;20:835-46.
21. Zhang YW, Vande Woude GF. HGF/SF-met signaling in the control of branching morphogenesis and invasion. J Cell Biochem 2003;88:408-17.
22. Giordano S, Corso S, Conrotto P, et al. The semaphorin 4D receptor controls invasive growth by coupling with Met. Nat Cell Biol 2002;4:720-4.
23. Tessier-Lavigne M, Goodman CS. The molecular biology of axon guidance. Science (Wash DC) 1996;274:1123-33.
24. Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Proc Natl Acad Sci USA 2002;99:12085-90.
25. Hirotani M, Ohoka Y, Yamamoto T, et al. Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors. Biochem Biophys Res Commun 2002;297:32-7.
26. Perrot V, Vazquez-Prado J, Gutkind JS. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-Rho-GEF. J Biol Chem 2002;277:43115-20.
27. Swierez JM, Kuner R, Behrens J, Offermanns S. Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron 2002;35:51-63.
28. Chen C, Okayama H. High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 1987;7:2745-52.
29. Kibbey MC, Yamamura K, Jun SH, Grant DS, Kleinman HK. Enhancement of tumor growth by basement membrane: modulation of growth and angiogenesis by laminin-derived synthetic peptides. Cancer Treat Res 1994;71:267-75.
30. Passaniti A, Taylor RM, Pili R, et al. A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab Investig 1992;67:519-28.
31. Naldini L, Blomer U, Gage FH, Trono D, Verma TM. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci USA 1996;93:11382-8.
32. Boukamp P, Petrussevska RT, Breitkreutz D, et al. Normal keralinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988;106:761-71.
33. Coloma MJ, Hastings A, Wims LA. Morrison SL. Novel vectors for the expression of antibody molecules using variable regions generated by polymerase chain reaction. J Immunol Methods 1992;152:89-104.
34. Cross MJ, Claesson-Welsh L. FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition. Trends Pharmacol Sci 2001;22:201-7.
35. Bussolino F, Di Renzo MF, Ziehe M, et al. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 1992;119:629-41.
36. Rosen EM, Goldberg ID. Regulation of angiogenesis by scatter factor. Experientia Supplementum 1997;79:193-208.
37. Kubota Y, Kleinman HK, Martin GR, Lawley TJ. Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures. J Cell Biol 1988;107:1589-98.
38. Parums DV, Cordell JL, Micklem K, et al. JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. J Clin Pathol 1990;43:752-7.
39. Sheng M, Sala C. PDZ domains and the organization of supramolecular complexes. Annu Rev Neurosci 2001;24:1-29.
40. Fukuhara S, Murga C, Zohar M, Igishi T, Gutkind JS. A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J Biol Chem 1999;274:5868-79.
41. Fukuhara S, Chikumi H, Gutkind JS. Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho. FEBS Lett 2000;485:183-8.
42. Ridley AJ, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 1992;70:389-99.
43. Whitford KL, Ghosh A. Plexin signaling via off-track and rho family GTPases. Neuron 2001;32:1-3.
44. Driessens MH, Hu H, Nobes CD, et al. Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho. Curr Biol 2001;11:339-44.
45. Tamagnone L, Comoglio PM. Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors. Cytokine Growth Factor Rev 1997;8:129-42.
46. Dong G, Chen Z, Li ZY, et al. Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma. Cancer Res 2001;61:5911-8.
47. Miao HQ, Soker S, Feiner L, et al. Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165. J Cell Biol 1999;146:233-42.
48. Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999;13:9-22.
49. : Puschel AW. The function of neuropilin/plexin complexes. Adv Exp. Med Biol 2002;515:71-80.
50. Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG. B plexins activate Rho through PDZ-RhoGEF. FEBS Lett 2002;529:168-72.
51. Liu BP, Strittmatter SM. Semaphorin-mediated axonal guidance via Rho-related G proteins. Curr Opin Cell Biol 2001;13:619-26.
52. Oinuma I, Katoh H, Harada A, Negishi M. Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. J Biol Chem 2003;278:25671-7.
53. Hu H, Marion TF, Goodman CS. Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling. Neuron 2001;32:39-51.
54. Vikis HG, Li W, Guan KL. The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Genes Dev 2002;16:836-45.
55. Buschmann I, Heil M, Jost M, Schaper W. Influence of inflammatory cytokines on arteriogenesis. Microcirculation 2003;10:371-9.
56. Yancopoulos GD, Klagsbrun M, Folkman J. Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border. Cell 1998;93:661-4.
57. van der Zwaag B, Hellemons AJ, Leenders WP, et al. PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis. Dev Dyn 2002;225:336-43.
58. Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998;92:735-45.