A new microrheometric approach reveals individual and cooperative roles for TGF-β1 and IL-1β in fibroblast-mediated stiffening of collagen gels

FASEB Journal

Volumn 21, Issue 9, 2007, Pages 2064-2073

  Leung, Lester Y ^a   Tian, David ^a   Brangwynne, Clifford P ^b   Weitz, David A ^b   Tschumperlin, Daniel J ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Compliance; Extracellular matrix; Fibrosis; Myofibroblast; Remodeling

Indexed keywords

COLLAGEN GEL; COLLAGEN TYPE 1; CYTOKINE; INTERLEUKIN 1BETA; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; BIOLOGICAL ACTIVITY; CELL ACTIVITY; CELL AGGREGATION; CELL ASSAY; CELL FUNCTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROBLAST; FLOW MEASUREMENT; HUMAN; HUMAN CELL; MAGNETIC FIELD; PRIORITY JOURNAL;

ACTINS; CELLS, CULTURED; COLLAGEN; COLLAGEN TYPE I; COLLAGEN TYPE III; COMPUTER SYSTEMS; CYTOKINES; DRUG SYNERGISM; ELASTICITY; EXTRACELLULAR MATRIX; FIBROBLASTS; GELS; GENE EXPRESSION REGULATION; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-1BETA; LUNG; MAGNETICS; MATERIALS TESTING; MICROCHEMISTRY; MICROSPHERES; PLATELET-DERIVED GROWTH FACTOR; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; RHEOLOGY; ROTATION; TORQUE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 34347402254     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7510com     Document Type: Article

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