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Volumn 25, Issue 4, 2007, Pages 240-248

Downregulation of NPM-ALK by siRNA causes anaplastic large cell lymphoma cell growth inhibition and augments the anti cancer effects of chemotherapy in vitro

Author keywords

ALCL; Lymphoma; siRNA

Indexed keywords

DOXORUBICIN; HYBRID PROTEIN; NUCLEOPHOSMIN ANAPLASTIC LYMPHOMA KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 34347396141     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.1080/07357900701206372     Document Type: Article
Times cited : (27)

References (37)
  • 1
    • 0021972684 scopus 로고
    • The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells
    • Stein, H.; Mason, D.Y.; Gerdes, J.; O'Connor, N.; Wainscoat, J.; et al.: The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 1985, 66, 848-858.
    • (1985) Blood , vol.66 , pp. 848-858
    • Stein, H.1    Mason, D.Y.2    Gerdes, J.3    O'Connor, N.4    Wainscoat, J.5
  • 2
    • 0031689795 scopus 로고    scopus 로고
    • ALK expression defines a distinct group of T/null lymphomas ("ALK lymphomas") with a wide morphological spectrum
    • Falini, B.; Bigerna, B.; Fizzotti, M.; Pulford, K.; Pileri, S.A.; et al. ALK expression defines a distinct group of T/null lymphomas ("ALK lymphomas") with a wide morphological spectrum. Am. J. Pathol. 1998, 153, 875-886.
    • (1998) Am. J. Pathol , vol.153 , pp. 875-886
    • Falini, B.1    Bigerna, B.2    Fizzotti, M.3    Pulford, K.4    Pileri, S.A.5
  • 3
    • 0031035052 scopus 로고    scopus 로고
    • Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system
    • Iwahara, T.; Fujimoto, J.; Wen, D.; Cupples, R.; Bucay, N.; et al. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene 1997, 14, 439-449
    • (1997) Oncogene , vol.14 , pp. 439-449
    • Iwahara, T.1    Fujimoto, J.2    Wen, D.3    Cupples, R.4    Bucay, N.5
  • 4
    • 0037384714 scopus 로고    scopus 로고
    • Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells
    • Ruchatz, H.; Coluccia, A.M.; Stano, P.; Marchesi, E.; Gambacorti-Passerini, C. Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells. Exp. Hematol. 2003, 31, 309-315.
    • (2003) Exp. Hematol , vol.31 , pp. 309-315
    • Ruchatz, H.1    Coluccia, A.M.2    Stano, P.3    Marchesi, E.4    Gambacorti-Passerini, C.5
  • 5
    • 0034653984 scopus 로고    scopus 로고
    • Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis
    • Ma, Z.; Cools, J.; Marynen, P.; Cui, X.; Siebert, R.; et al. Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis. Blood 2000, 95, 2144-2149.
    • (2000) Blood , vol.95 , pp. 2144-2149
    • Ma, Z.1    Cools, J.2    Marynen, P.3    Cui, X.4    Siebert, R.5
  • 6
    • 0344850198 scopus 로고    scopus 로고
    • TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations
    • Hernandez, L.; Pinyol, M.; Hernandez, S.; Bea, S.; Pulford, K.; et al. TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations. Blood 1999, 94, 3265-3268.
    • (1999) Blood , vol.94 , pp. 3265-3268
    • Hernandez, L.1    Pinyol, M.2    Hernandez, S.3    Bea, S.4    Pulford, K.5
  • 7
    • 0036111194 scopus 로고    scopus 로고
    • Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: Identification of a new TFGALK( XL) chimeric gene with transforming activity
    • Hernandez, L.; Bea, S.; Bellosillo, B.; Pinyol, M.; Falini, B.; et al. Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFGALK( XL) chimeric gene with transforming activity. Am. J. Pathol. 2002, 160, 1487-1494.
    • (2002) Am. J. Pathol , vol.160 , pp. 1487-1494
    • Hernandez, L.1    Bea, S.2    Bellosillo, B.3    Pinyol, M.4    Falini, B.5
  • 8
    • 18444407158 scopus 로고    scopus 로고
    • Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatorymyofibroblastic tumor
    • Cools, J.; Wlodarska, I.; Somers, R.; Mentens, N.; Pedeutour, F.; et al. Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatorymyofibroblastic tumor. Genes Chromosomes Cancer 2002, 34, 354-362.
    • (2002) Genes Chromosomes Cancer , vol.34 , pp. 354-362
    • Cools, J.1    Wlodarska, I.2    Somers, R.3    Mentens, N.4    Pedeutour, F.5
  • 9
    • 0033899383 scopus 로고    scopus 로고
    • ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35)
    • Colleoni, G.W.; Bridge, J.A.; Garicochea, B.; Liu, J.; Filippa, D.A.; et al. ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35). Am. J. Pathol. 2000, 156, 781-789.
    • (2000) Am. J. Pathol , vol.156 , pp. 781-789
    • Colleoni, G.W.1    Bridge, J.A.2    Garicochea, B.3    Liu, J.4    Filippa, D.A.5
  • 10
    • 0033168265 scopus 로고    scopus 로고
    • t(1;2)(q21;p23) and t(2;3)(p23;q21): Two novel variant translocations of the t(2;5)(p23;q35) in anaplastic large cell lymphoma
    • Rosenwald, A.; Ott, G.; Pulford, K.; Katzenberger, T.; Kuhl, J.; et al t(1;2)(q21;p23) and t(2;3)(p23;q21): two novel variant translocations of the t(2;5)(p23;q35) in anaplastic large cell lymphoma. Blood 1999, 94, 362-364.
    • (1999) Blood , vol.94 , pp. 362-364
    • Rosenwald, A.1    Ott, G.2    Pulford, K.3    Katzenberger, T.4    Kuhl, J.5
  • 11
    • 0035086796 scopus 로고    scopus 로고
    • Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma
    • Tort, F.; Pinyol, M.; Pulford, K.; Roncador, G.; Hernandez, L.; et al. Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma. Lab. Invest. 2001, 81, 419-426.
    • (2001) Lab. Invest , vol.81 , pp. 419-426
    • Tort, F.1    Pinyol, M.2    Pulford, K.3    Roncador, G.4    Hernandez, L.5
  • 12
    • 0034652639 scopus 로고    scopus 로고
    • A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma
    • Trinei, M.; Lanfrancone, L.; Campo, E.; Pulford, K.; Mason, D.Y.; et al. A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma. Cancer Res. 2000, 60, 793-798.
    • (2000) Cancer Res , vol.60 , pp. 793-798
    • Trinei, M.1    Lanfrancone, L.2    Campo, E.3    Pulford, K.4    Mason, D.Y.5
  • 13
    • 0032532272 scopus 로고    scopus 로고
    • The cryptic inv(2)(p23q35) defines a new molecular genetic subtype of ALK-positive anaplastic large-cell lymphoma
    • Wlodarska, I.; De Wolf-Peeters, C.; Falini, B.; Verhoef, G.; Morris, S.W.; et al. The cryptic inv(2)(p23q35) defines a new molecular genetic subtype of ALK-positive anaplastic large-cell lymphoma. Blood 1998, 92, 2688-2695.
    • (1998) Blood , vol.92 , pp. 2688-2695
    • Wlodarska, I.1    De Wolf-Peeters, C.2    Falini, B.3    Verhoef, G.4    Morris, S.W.5
  • 14
    • 13344250482 scopus 로고    scopus 로고
    • Molecular characterization of the t(2;5) (p23; q35) translocation in anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease
    • Yee, H.T.; Ponzoni, M.; Merson, A.; Goldstein, M.; Scarpa, A.; et al. Molecular characterization of the t(2;5) (p23; q35) translocation in anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease. Blood 1996, 87, 1081-1088.
    • (1996) Blood , vol.87 , pp. 1081-1088
    • Yee, H.T.1    Ponzoni, M.2    Merson, A.3    Goldstein, M.4    Scarpa, A.5
  • 15
    • 0024966024 scopus 로고    scopus 로고
    • Borer, R.A.; Lehner, C.F.; Eppenberger, H.M.; Nigg, E.A. Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell 1989, 56, 379-390.
    • Borer, R.A.; Lehner, C.F.; Eppenberger, H.M.; Nigg, E.A. Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell 1989, 56, 379-390.
  • 16
    • 0030934862 scopus 로고    scopus 로고
    • Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphomaassociated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis
    • Bischof, D.; Pulford, K.; Mason, D.Y.; Morris, S.W. Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphomaassociated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis. Mol. Cell Biol. 1997, 17, 2312-2325.
    • (1997) Mol. Cell Biol , vol.17 , pp. 2312-2325
    • Bischof, D.1    Pulford, K.2    Mason, D.Y.3    Morris, S.W.4
  • 17
    • 0031755958 scopus 로고    scopus 로고
    • Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity
    • Bai, R.Y.; Dieter, P.; Peschel, C.; Morris, S.W.; Duyster, J. Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity. Mol. Cell Biol. 1998, 18, 6951-6961.
    • (1998) Mol. Cell Biol , vol.18 , pp. 6951-6961
    • Bai, R.Y.1    Dieter, P.2    Peschel, C.3    Morris, S.W.4    Duyster, J.5
  • 18
    • 85047699293 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
    • Zamo, A.; Chiarle, R.; Piva, R.; Howes, J.; Fan, Y.; et al. Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death. Oncogene 2002, 21, 1038-1047.
    • (2002) Oncogene , vol.21 , pp. 1038-1047
    • Zamo, A.1    Chiarle, R.2    Piva, R.3    Howes, J.4    Fan, Y.5
  • 19
    • 0036134884 scopus 로고    scopus 로고
    • Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma
    • Zhang, Q.; Raghunath, P.N.; Xue, L.; Majewski, M.; Carpentieri, D.F.; et al. Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma. J. Immunol. 2002, 168, 466-474.
    • (2002) J. Immunol , vol.168 , pp. 466-474
    • Zhang, Q.1    Raghunath, P.N.2    Xue, L.3    Majewski, M.4    Carpentieri, D.F.5
  • 20
    • 0034672140 scopus 로고    scopus 로고
    • Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway
    • Bai, R.Y.; Ouyang, T.; Miething, C.; Morris, S.W.; Peschel, C.; Duyster, J. Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway. Blood 2000, 96, 4319-4327.
    • (2000) Blood , vol.96 , pp. 4319-4327
    • Bai, R.Y.1    Ouyang, T.2    Miething, C.3    Morris, S.W.4    Peschel, C.5    Duyster, J.6
  • 21
    • 0035266314 scopus 로고    scopus 로고
    • Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis
    • Slupianek, A.; Nieborowska-Skorska, M.; Hoser, G.; Morrione, A.; Majewski, M.; et al. Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis. Cancer Res. 2001, 61, 2194-2199.
    • (2001) Cancer Res , vol.61 , pp. 2194-2199
    • Slupianek, A.1    Nieborowska-Skorska, M.2    Hoser, G.3    Morrione, A.4    Majewski, M.5
  • 22
    • 0842264006 scopus 로고    scopus 로고
    • Nucleophosmin-anaplastic lymphoma kinase of anaplastic largecell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity
    • Cussac, D.; Greenland, C.; Roche, S.; Bai, R.Y.; Duyster, J.; et al. Nucleophosmin-anaplastic lymphoma kinase of anaplastic largecell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity. Blood 2004, 103, 1464-1471.
    • (2004) Blood , vol.103 , pp. 1464-1471
    • Cussac, D.1    Greenland, C.2    Roche, S.3    Bai, R.Y.4    Duyster, J.5
  • 23
    • 0030003813 scopus 로고    scopus 로고
    • Characterization of th transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)
    • Fujimoto, J.; Shiota, M.; Iwahara, T.; Seki, N.; Saton, H.; et al. Characterization of th transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5). Proc. Natl. Acad. Sci. 1996, 93, 4181-4186.
    • (1996) Proc. Natl. Acad. Sci , vol.93 , pp. 4181-4186
    • Fujimoto, J.1    Shiota, M.2    Iwahara, T.3    Seki, N.4    Saton, H.5
  • 24
    • 0030809095 scopus 로고    scopus 로고
    • Retrovirus-mediated gene transfer of NPM-ALK causes lymphoid malignancy in mice
    • Kuefer, M.U.; Look, A.T.; Pulford, K.; Behm, F.G.; Pattengale, P.K.; et al. Retrovirus-mediated gene transfer of NPM-ALK causes lymphoid malignancy in mice. Blood 1997, 90, 2901-2910.
    • (1997) Blood , vol.90 , pp. 2901-2910
    • Kuefer, M.U.1    Look, A.T.2    Pulford, K.3    Behm, F.G.4    Pattengale, P.K.5
  • 25
    • 0037372285 scopus 로고    scopus 로고
    • NPMALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors
    • Chiarle, R.; Gong, J.Z.; Guasparri, I.; Pesci, A.; Cai, J.; et al. NPMALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors. Blood 2003, 101, 1919-1927.
    • (2003) Blood , vol.101 , pp. 1919-1927
    • Chiarle, R.1    Gong, J.Z.2    Guasparri, I.3    Pesci, A.4    Cai, J.5
  • 26
    • 0043091984 scopus 로고    scopus 로고
    • The oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces two distinct malignant phenotypes in a murine retroviral transplantation model
    • Miething, C.;Grundler, R.; Fend, F.; Hoepfl, J.; Mugler, C.; et al. The oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces two distinct malignant phenotypes in a murine retroviral transplantation model. Oncogene 2003, 22, 4642-4647.
    • (2003) Oncogene , vol.22 , pp. 4642-4647
    • Miething, C.1    Grundler, R.2    Fend, F.3    Hoepfl, J.4    Mugler, C.5
  • 27
    • 0034888811 scopus 로고    scopus 로고
    • Inhibition of tyrosine kinase activity induces caspasedependent apoptosis in anaplastic large cell lymphoma with NPM-ALK (p80) fusion protein
    • Ergin, M.; Denning, M.F.; Izban, K.F.; Amin, H.M.; Martinez, R.L.; et al. Inhibition of tyrosine kinase activity induces caspasedependent apoptosis in anaplastic large cell lymphoma with NPM-ALK (p80) fusion protein. Exp. Hematol. 2001, 29, 1082-1090.
    • (2001) Exp. Hematol , vol.29 , pp. 1082-1090
    • Ergin, M.1    Denning, M.F.2    Izban, K.F.3    Amin, H.M.4    Martinez, R.L.5
  • 28
    • 2342540711 scopus 로고    scopus 로고
    • Hammerhead ribozyme-mediated cleavage of the fusion transcript NPM-ALK associated with anaplastic large-cell lymphoma
    • Hubinger, G.; Wehnes, E.; Xue, L.; Morris, S.W.; Maurer, U. Hammerhead ribozyme-mediated cleavage of the fusion transcript NPM-ALK associated with anaplastic large-cell lymphoma. Exp. Hematol. 2003, 31, 226-233.
    • (2003) Exp. Hematol , vol.31 , pp. 226-233
    • Hubinger, G.1    Wehnes, E.2    Xue, L.3    Morris, S.W.4    Maurer, U.5
  • 29
    • 1642523434 scopus 로고    scopus 로고
    • Design and evaluation of chemically synthesized siRNA targeting the NPM-ALK fusion site in anaplastic large cell lymphoma (ALCL)
    • Ritter, U.; Damm-Welk, C.; Fuchs, U.; Bohle, R.M.; Borkhardt, A.; Woessmann, W. Design and evaluation of chemically synthesized siRNA targeting the NPM-ALK fusion site in anaplastic large cell lymphoma (ALCL). Oligonucleotides 2003, 13, 365-373.
    • (2003) Oligonucleotides , vol.13 , pp. 365-373
    • Ritter, U.1    Damm-Welk, C.2    Fuchs, U.3    Bohle, R.M.4    Borkhardt, A.5    Woessmann, W.6
  • 30
    • 0037049772 scopus 로고    scopus 로고
    • Inhibition of the Bcr-Abl tyrosine kinase as a therapeutic strategy for CML
    • Druker, B.J. Inhibition of the Bcr-Abl tyrosine kinase as a therapeutic strategy for CML. Oncogene 2002, 21, 8541-8546.
    • (2002) Oncogene , vol.21 , pp. 8541-8546
    • Druker, B.J.1
  • 31
    • 0141790842 scopus 로고    scopus 로고
    • Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571)
    • Wohlbold, L.; Van Der Kuip, H.; Miething, C.; Vornlocher, H.P.; Knabbe, C.; et al. Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571). Blood 2003, 102 (6), 2236-2239.
    • (2003) Blood , vol.102 , Issue.6 , pp. 2236-2239
    • Wohlbold, L.1    Van Der Kuip, H.2    Miething, C.3    Vornlocher, H.P.4    Knabbe, C.5
  • 32
    • 0037441756 scopus 로고    scopus 로고
    • Specific inhibition of bcr-abl gene expression by small interfering RNA
    • Scherr, M.; Battmer, K.; Winkler, T.; Heidenreich, O.; Ganser, A.; Eder, M. Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood 2003, 101, 1566-1569.
    • (2003) Blood , vol.101 , pp. 1566-1569
    • Scherr, M.1    Battmer, K.2    Winkler, T.3    Heidenreich, O.4    Ganser, A.5    Eder, M.6
  • 33
    • 0035504078 scopus 로고    scopus 로고
    • Expression of the oncogenic NPM-ALK chimeric protein in human lymphoid T-cells inhibits drug-induced, but not Fas-induced apoptosis
    • Greenland, C.; Touriol, C.; Chevillard, G.; Morris, S.W.; Bai, R.; et al. Expression of the oncogenic NPM-ALK chimeric protein in human lymphoid T-cells inhibits drug-induced, but not Fas-induced apoptosis. Oncogene 2001, 20, 7386-7397.
    • (2001) Oncogene , vol.20 , pp. 7386-7397
    • Greenland, C.1    Touriol, C.2    Chevillard, G.3    Morris, S.W.4    Bai, R.5
  • 34
    • 0142200927 scopus 로고    scopus 로고
    • A case of a diffuse large B-cell lymphoma of plasmablastic type associated with the t(2;5)(p23;q35) chromosome translocation nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity
    • Adam, P.; Katzenberger, T.; Seeberger, H.; Gattenlohner, S.; Wolf, J.; et al. A case of a diffuse large B-cell lymphoma of plasmablastic type associated with the t(2;5)(p23;q35) chromosome translocation nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity. Am. J. Surg. Pathol. 2003, 27, 1473-1476.
    • (2003) Am. J. Surg. Pathol , vol.27 , pp. 1473-1476
    • Adam, P.1    Katzenberger, T.2    Seeberger, H.3    Gattenlohner, S.4    Wolf, J.5
  • 35
    • 0043073841 scopus 로고    scopus 로고
    • Expression of anaplastic lymphoma kinase in non-Hodgkin's lymphomas and other malignant neoplasms. biological, diagnostic, and clinical implications
    • Wasik, M.A. Expression of anaplastic lymphoma kinase in non-Hodgkin's lymphomas and other malignant neoplasms. biological, diagnostic, and clinical implications. Am. J. Clin. Pathol. 2002, 118 (Suppl), S81-92.
    • (2002) Am. J. Clin. Pathol , vol.118 , Issue.SUPPL.
    • Wasik, M.A.1
  • 36
    • 30444446194 scopus 로고    scopus 로고
    • Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas
    • Piva, R.; et al. Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas. Blood 2006, 107, 689-697.
    • (2006) Blood , vol.107 , pp. 689-697
    • Piva, R.1
  • 37
    • 27944485366 scopus 로고    scopus 로고
    • Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
    • Marzec, M.; et al. Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3. Lab. Invest. 2005, 85, 1544-1554.
    • (2005) Lab. Invest , vol.85 , pp. 1544-1554
    • Marzec, M.1


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