ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35)

American Journal of Pathology

Volumn 156, Issue 3, 2000, Pages 781-789

  Colleoni, Gisele W B ^a   Bridge, Julia A ^b   Garicochea, Bernardo ^a   Liu, Jian ^b   Filippa, Daniel A ^a   Ladanyi, Marc ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE;

ADULT; ARTICLE; CASE REPORT; CHROMOSOME INVERSION; FEMALE; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE FUSION; GENE MAPPING; GENE REARRANGEMENT; GENE TRANSLOCATION; GENETIC VARIABILITY; HUMAN; LARGE CELL LYMPHOMA; PRIORITY JOURNAL; PROGNOSIS; SCHOOL CHILD;

EID: 0033899383     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64945-0     Document Type: Article

References (48)

1. Clinicopathologic features and treatment outcome of children with large-cell lymphoma and the t(2;5)(p23;q35)
2. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease
3. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF
4. CD30 (Ki-1)-positive malignant lymphomas: Clinical, immunophenotypic, histologic, and genetic characteristics and differences with Hodgkin's disease
5. Ki-1-positive anaplastic large-cell lymphoma a clinicopathologic entity?
6. Ki-1/CD30+ (anaplastic) large-cell lymphoma: Maturation of a clinicopathologic entity with prospects of effective therapy
7. CD30 positive large cell lymphomas ('Ki-1 lymphoma') are associated with a chromosomal translocation involving 5q35
8. Immunohistochemical, molecular, and cytogenetic analysis of a consecutive series of 20 peripheral T cell lymphomas, and lymphomas of uncertain lineage, including 12 Ki-1 positive lymphomas
9. Molecular detection of the t(2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction
10. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
11. ALK, the chromosome 2 gene locus altered by the t(2; 5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
12. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system
13. The NPM/ALK fusion gene in the pathogenesis of anaplastic large cell lymphoma
14. Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis
15. Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1
16. ALK expression defines a distinct group of T/null lymphomas ('ALK lymphomas') with a wide morphological spectrum
17. Diagnosis of t(2;5)(p23:q35:associated Ki-1 lymphoma with immunohistochemistry
18. Use of an anti-ALK antibody in the characterization ot anaplastic large-cell lymphoma of childhood
19. The monoclonal antibody ALK1 identifies a distinct morphological subtype of anaplastic large cell lymphoma associated with 2p23/ALK rearrangements
20. Nucleolar localization of the nucleophosmin-anaplastic lymphoma kinase is not required for malignant transformation
21. ALK-positive lymphoma: A single disease with a broad spectrum of morphology
22. ALK+ lymphoma: Clinico-pathological findings and outcome
23. Biochemical detection of novel anaplastic lymphoma kinase proteins in tissue sections of anaplastic large cell lymphoma
24. A novel variant translocation t(2;13)(p23;q34) in Ki-1 large cell anaplastic lymphoma
25. High incidence of the t(2;5)(p23;q35) translocation in anaplastic large cell lymphoma and its lack of detection in Hodgkin's disease. Comparison of cytogenetic analysis, reverse transcriptase-polymerase chain reaction, and p-80 immunostaining
26. The cryptic inv(2)(p23q35) defines a new molecular genetic subtype of ALK-positive anaplastic large-cell lymphoma
27. t(1; 2)(q21; p23) and t(2; 3)(p23; q21): Two novel variant translocations of the t(2; 5)(p23; q35) in anaplastic large cell lymphoma
28. A new fusion gene TPM3-ALK in anapiastic large cell lymphoma created by a (1;2)(q25;p23) translocation
29. Rearrangements of TRK proto-oncogene in papillary thyroid carcinomas
30. Detection of the NPM-ALK genomic rearrangement of Ki-1 lymphoma and isolation of the involved NPM and ALK introns
31. Molecular variant of the NPM-ALK rearrangement of Ki-1 lymphoma involving a cryptic ALK splice site
32. Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization. An intergroup rhabdomyosarcoma study
33. Structure and functional relationships in human pur H
34. Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase
35. The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping
36. In vivo amplification of the PAX3-FKHR, and PAX7-FKHR fusion genes in alveolar rhabdomyosarcoma
37. Novel formation and amplification of the PAX7-FKHR fusion gene in a case of alveolar rhabdomyosarcoma
38. Translocations cancer, and the puzzle of specificity
39. The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosminretinoic acid receptor fusion
40. The t(3;5)(q25.1;q34) of myelodysplatic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1
41. Translocation (1;5)(q32;q35) in CD30+ anaplastic large cell non-Hodgkin lymphoma of childhood
42. Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors
43. Ki-1 antigen expression defines a favorable clinical subset of non-B-cell non-Hodgkin's lymphoma
44. Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma
45. Anaplastic large cell lymphomas expressing the novel chimeric protein p80 npm/alk: A distinct clinicopathologic entity
46. Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma
47. ALK gene products in anaplastic large cell lymphomas and Hodgkin's disease
48. Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive ALK tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis