Effects of GM-CSF, IL-3, and GM-CSF/IL-3 fusion protein on apoptosis of human myeloid leukemic cell line Tf-1 induced by irradiation

Acta Pharmacologica Sinica

Volumn 25, Issue 1, 2004, Pages 68-75

  Yang, Su Rong ^a   Wen, Li ^a   Lu, Ying Qing ^a   Gong, Qin Yan ^a   Yu, Rong ^a   Yao, Ming Hui ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Apoptosis; Caspases; Cultured cells; Flow cytometry; Granulocyte macrophage colony stimulating factor; Interleukin 3; Radiation; Recombinant fusion proteins

Indexed keywords

CASPASE 3; DNA FRAGMENT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYBRID PROTEIN; INTERLEUKIN 3;

APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; GAMMA IRRADIATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MYELOID LEUKEMIA; TRANSMISSION ELECTRON MICROSCOPY;

APOPTOSIS; CASPASE 3; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; CESIUM RADIOISOTOPES; DNA FRAGMENTATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-3; LEUKEMIA, MYELOID; RECOMBINANT FUSION PROTEINS;

EID: 0347024225     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Williams DE, Dunn JT, Park LS, Frieden EA, Seiler FR, Farese AM, et al. A GM-CSF/IL-3 fusion protein promotes neutrophil and platelet recovery in sublethally irradiated rhesus monkeys. Biotechnol Ther 1993; 4: 17-29.
2. Sun WM, Wang HQ. Methodology of studies of cytokines. 1st ed. Beijing: People's Medical Publishing House; 1999. p 412.
3. Curtis BM, Williams DE, Broxmeyer HE, Dunn J, Farrah T, Jeffery E, et al. Enhanced hematopoietic activity of a human granulocyte/macrophage colony-stimulating factor-interleukin 3 fusion protein. Proc Natl Acad Sci USA 1991; 88: 5809-13.
4. Vose JM, Armifage JO. Clinical applications of hematopoietic growth factors. J Clin Oncol 1995; 13: 1023-35.
5. Chen GY, Gong ML, Lu J, Zhao HY, Shen QJ, Zhou M. Therapeutic effect of G3 in rhesus monkeys with bone marrow form acute radiation sickness. Chin J Radiol Med Prot 1999; 19: 375-8.
6. Jones SE, Khandelwal P, McIntyre K, Mennel R, Orr D, Kirby R, et al. Randomized, double-blind, placebo-controlled trial to evaluate the hematopoietic growth factor PIXY321 after moderate-dose fluorouracil, doxorubicin, and cyclophosphamide in stage II and III breast cancer. J Clin Oncol 1999; 17: 3025-32.
7. Murren JR, Gollerkeri A, Anderson S, Lutzker S, Del Prete S, Zelterman D, et al. Peripheral blood progenitor cell cycle kinetics following priming with pIXY321 in patients treated with the "ICE" regimen. Yale J Biol Med 1999; 71: 355-65.
8. Klampfer L, Zhang J, Nimer SD. GM-CSF rescues Tf-1 cells from growth factor withdrawal-induced, but not differentiation-induced apoptosis: the role of bcl-2 and Mcl-1. Cytokine 1999; 11: 849-55.
9. Kelly ML, Tang Y, Rosensweig N, Clejan S, Beckman BS. Granulocyte-macrophage colony-stimulating factor rescues Tf-1 leukemia cells from ionizing radiation-induced apoptosis through a pathway mediated by protein kinase Ca. Blood 1998; 92: 416-24.
10. Itakura A, Tanaka A, Aioi A, Tonogaito H, Matsuda H. Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor. Exp Hematol 2002; 30: 272-8.
11. HAN JH, Gileadi C, Rajapaksa R, Kosek J, Greenberg PL. Modulation of apoptosis in human myeloid leukemic cells by GM-CSF. Exp Hematol 1995; 23: 265-72.
12. Gisslinger H, Kurzrock R, Wetzler M, Tucker S, Kantarjian H, Robertson B, et al. Apoptosis in chronic myelogenous leukemia: studies of stage-specific differences. Leuk Lymph 1997; 25: 121-33.
13. Burton K. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 1956; 62: 315-23.
14. McIlroy D, Sakahira H, Talanian RV, Talanian RV, Nagata S. Involvement of caspase-3-activated DNase in internucleosomal DNA cleavage induced by diverse apoptotic stimuli. Oncogene 1999; 18: 4401-8.
15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75.
16. Su X, Jin GH, Xue LX, Liu JX, Fu SB, Liu SZ. Effect of ionizing radiation on cell cycle of tumor cell lines. Chin J Radiol Med Prot 2000; 20: 168-170.
17. Drouet M, Mathieu J, Grenier N, Multon E, Sotto JJ, Herodin F. The reduction of in vitro radiation-induced Fas-related apoptosis in CD34+ progenitor cells by SCF, FLT-3 ligand, and IL-3 in combination resulted in CD34+ cell proliferation and differentiation. Stem Cell 1999; 17: 273-85.
18. Kitamura T, Tange T, Terasawa T, Chiba S, Kuwaki T, Miyagawa K, et al. Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3 or erythropoietin. J Cell Physiol 1989; 140: 323-34.
19. Weinstein-Oppenheimer C, Steelman LS, Algate PA, Blalock WL, Burrows C, Hoyle PE, et al. Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells. Leukemia 2000; 14: 1921-38.
20. Zhang M, Zhang HQ, Xue SB. Effect of bcl-2 and caspase-3 on calcium distribution in apoptosis of HL-60 cells. Cell Res 2000; 10: 213-20.
21. Enari M, Talanian RV, Wong WW, Nagata S. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 1996; 380: 723-6.