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Volumn 273, Issue 1-2, 2007, Pages 6-15

Adeno-associated viral delivery of a metabolically regulated insulin transgene to hepatocytes

Author keywords

AAV2; Adeno associated virus; Diabetes; Gene therapy; Transcriptional regulation

Indexed keywords

ADENOVIRUS VECTOR; E1A PROTEIN; GLUCOSE; INSULIN;

EID: 34347327249     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2007.04.011     Document Type: Article
Times cited : (16)

References (52)
  • 1
    • 0035163792 scopus 로고    scopus 로고
    • Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column
    • Auricchio A., Hildinger M., et al. Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column. Hum. Gene Ther. 12 1 (2001) 71-76
    • (2001) Hum. Gene Ther. , vol.12 , Issue.1 , pp. 71-76
    • Auricchio, A.1    Hildinger, M.2
  • 2
    • 0033998692 scopus 로고    scopus 로고
    • Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors
    • Bartlett J.S., Wilcher R., et al. Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors. J. Virol. 74 6 (2000) 2777-2785
    • (2000) J. Virol. , vol.74 , Issue.6 , pp. 2777-2785
    • Bartlett, J.S.1    Wilcher, R.2
  • 3
    • 2542478210 scopus 로고    scopus 로고
    • The activity of the feline thyroglobulin promoter is compromised by flanking adenoviral sequence
    • Blackwood L., and Argyle D.J. The activity of the feline thyroglobulin promoter is compromised by flanking adenoviral sequence. Vet. J. 168 1 (2004) 50-59
    • (2004) Vet. J. , vol.168 , Issue.1 , pp. 50-59
    • Blackwood, L.1    Argyle, D.J.2
  • 4
    • 0031039171 scopus 로고    scopus 로고
    • Comparison of retroviral and adeno-associated viral vectors designed to express human clotting factor IX
    • Chen L., Perlick H., et al. Comparison of retroviral and adeno-associated viral vectors designed to express human clotting factor IX. Hum. Gene Ther. 8 2 (1997) 125-135
    • (1997) Hum. Gene Ther. , vol.8 , Issue.2 , pp. 125-135
    • Chen, L.1    Perlick, H.2
  • 5
    • 0034984540 scopus 로고    scopus 로고
    • Auto-regulated hepatic insulin gene expression in type 1 diabetic rats
    • Chen R., Meseck M., et al. Auto-regulated hepatic insulin gene expression in type 1 diabetic rats. Mol. Ther. 3 4 (2001) 584-590
    • (2001) Mol. Ther. , vol.3 , Issue.4 , pp. 584-590
    • Chen, R.1    Meseck, M.2
  • 6
    • 0036091935 scopus 로고    scopus 로고
    • Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats
    • Dong H., Altomonte J., et al. Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats. Diabetes 51 1 (2002) 130-138
    • (2002) Diabetes , vol.51 , Issue.1 , pp. 130-138
    • Dong, H.1    Altomonte, J.2
  • 7
    • 0035138205 scopus 로고    scopus 로고
    • Intracellular trafficking of adeno-associated virus vectors: routing to the late endosomal compartment and proteasome degradation
    • Douar A.M., Poulard K., et al. Intracellular trafficking of adeno-associated virus vectors: routing to the late endosomal compartment and proteasome degradation. J. Virol. 75 4 (2001) 1824-1833
    • (2001) J. Virol. , vol.75 , Issue.4 , pp. 1824-1833
    • Douar, A.M.1    Poulard, K.2
  • 8
    • 0026547439 scopus 로고
    • Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation
    • Dunn J.C.Y., Tompkins R.G., et al. Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation. J. Cell Biol. 116 (1992) 1043-1053
    • (1992) J. Cell Biol. , vol.116 , pp. 1043-1053
    • Dunn, J.C.Y.1    Tompkins, R.G.2
  • 9
    • 0029923638 scopus 로고    scopus 로고
    • Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors
    • Ferrari F.K., Samulski T., et al. Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J. Virol. 70 5 (1996) 3227-3234
    • (1996) J. Virol. , vol.70 , Issue.5 , pp. 3227-3234
    • Ferrari, F.K.1    Samulski, T.2
  • 10
    • 0029655894 scopus 로고    scopus 로고
    • Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis
    • Fisher K.J., Gao P., et al. Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis. J. Virol. 70 1 (1996) 520-532
    • (1996) J. Virol. , vol.70 , Issue.1 , pp. 520-532
    • Fisher, K.J.1    Gao, P.2
  • 11
    • 0029151404 scopus 로고
    • Adeno-associated virus vectors for gene therapy
    • Flotte T.R., and Carter B.J. Adeno-associated virus vectors for gene therapy. Gene Ther. 2 6 (1995) 357-362
    • (1995) Gene Ther. , vol.2 , Issue.6 , pp. 357-362
    • Flotte, T.R.1    Carter, B.J.2
  • 12
    • 0032506752 scopus 로고    scopus 로고
    • Novel tools for production and purification of recombinant adenoassociated virus vectors
    • Grimm D., Kern A., et al. Novel tools for production and purification of recombinant adenoassociated virus vectors. Hum. Gene Ther. 9 18 (1998) 2745-2760
    • (1998) Hum. Gene Ther. , vol.9 , Issue.18 , pp. 2745-2760
    • Grimm, D.1    Kern, A.2
  • 13
    • 0028064783 scopus 로고
    • Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin
    • Groskreutz D.J., Sliwkowski M.X., et al. Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin. J. Biol. Chem. 269 (1994) 6241-6245
    • (1994) J. Biol. Chem. , vol.269 , pp. 6241-6245
    • Groskreutz, D.J.1    Sliwkowski, M.X.2
  • 14
    • 0008291328 scopus 로고    scopus 로고
    • Production of adeno-associated viral vectors
    • Dracopoli N., Haines J., Korf B., et al. (Eds), John Wiley & Sons, New York
    • Haberman R., Kroner-Lux G., et al. Production of adeno-associated viral vectors. In: Dracopoli N., Haines J., Korf B., et al. (Eds). Current Protocols in Human Genetics, Suppl. 23 (1999), John Wiley & Sons, New York 12.9.1-12.9.16
    • (1999) Current Protocols in Human Genetics, Suppl. 23
    • Haberman, R.1    Kroner-Lux, G.2
  • 15
  • 16
    • 33746909909 scopus 로고    scopus 로고
    • Evidence of multiyear Factor IX expression by AAV-mediated gene transfer to skeletal muscle in an individual with severe Hemophilia B
    • Jiang H., Pierce G.F., et al. Evidence of multiyear Factor IX expression by AAV-mediated gene transfer to skeletal muscle in an individual with severe Hemophilia B. Mol. Ther. 14 3 (2006) 452-455
    • (2006) Mol. Ther. , vol.14 , Issue.3 , pp. 452-455
    • Jiang, H.1    Pierce, G.F.2
  • 17
    • 33746840266 scopus 로고    scopus 로고
    • Complete prevention of atherosclerosis in apoE-deficient mice by hepatic human apoE gene transfer with adeno-associated virus serotypes 7 and 8
    • Kitajima K., Marchadier D.H.L., et al. Complete prevention of atherosclerosis in apoE-deficient mice by hepatic human apoE gene transfer with adeno-associated virus serotypes 7 and 8. Arterioscler. Throm. Vasc. Biol. 26 8 (2006) 1852-1857
    • (2006) Arterioscler. Throm. Vasc. Biol. , vol.26 , Issue.8 , pp. 1852-1857
    • Kitajima, K.1    Marchadier, D.H.L.2
  • 18
    • 33747600886 scopus 로고    scopus 로고
    • Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia
    • Koeberl D.D., Sun B.D., et al. Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia. Gene Ther. 13 17 (2006) 1281-1289
    • (2006) Gene Ther. , vol.13 , Issue.17 , pp. 1281-1289
    • Koeberl, D.D.1    Sun, B.D.2
  • 19
    • 0028963345 scopus 로고
    • Gene therapy for diabetes mellitus in rats by hepatic expression of insulin
    • Kolodka T.M., Finegold M., et al. Gene therapy for diabetes mellitus in rats by hepatic expression of insulin. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 3293-3297
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 3293-3297
    • Kolodka, T.M.1    Finegold, M.2
  • 20
    • 0034707028 scopus 로고    scopus 로고
    • Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue
    • Lee H.C., Kim J.-J., et al. Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature 408 23 (2000) 483-488
    • (2000) Nature , vol.408 , Issue.23 , pp. 483-488
    • Lee, H.C.1    Kim, J.-J.2
  • 21
    • 0029738626 scopus 로고    scopus 로고
    • Insulin-secreting non-islet cells are resistant to autoimmune destruction
    • Lipes M.A., Cooper E.M., et al. Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc. Natl. Acad. Sci. U.S.A. 93 16 (1996) 8595-8600
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , Issue.16 , pp. 8595-8600
    • Lipes, M.A.1    Cooper, E.M.2
  • 22
    • 33644820684 scopus 로고    scopus 로고
    • Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
    • Manno C.S., Arruda V.R., et al. Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat. Med. 12 3 (2006) 342-347
    • (2006) Nat. Med. , vol.12 , Issue.3 , pp. 342-347
    • Manno, C.S.1    Arruda, V.R.2
  • 23
    • 0346777307 scopus 로고    scopus 로고
    • Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo self-complementary adeno-associated virus serotype 2 vector: global distribution and broad dispersion of AAV-mediated transgene expression in mouse brain
    • McCarty D.M., Fu H., et al. Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo self-complementary adeno-associated virus serotype 2 vector: global distribution and broad dispersion of AAV-mediated transgene expression in mouse brain. Gene Ther. 10 26 (2003) 2112-2118
    • (2003) Gene Ther. , vol.10 , Issue.26 , pp. 2112-2118
    • McCarty, D.M.1    Fu, H.2
  • 24
    • 0034030443 scopus 로고    scopus 로고
    • Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: cell cycling does not influence hepatocyte transduction
    • Miao C.H., Nakai H., et al. Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: cell cycling does not influence hepatocyte transduction. J. Virol. 74 8 (2000) 3793-3803
    • (2000) J. Virol. , vol.74 , Issue.8 , pp. 3793-3803
    • Miao, C.H.1    Nakai, H.2
  • 25
    • 0031838721 scopus 로고    scopus 로고
    • Adeno-associated viral vector-mediated gene transfer of human blood coagulation factor IX in mouse liver
    • Nakai H., Herzog R.W., et al. Adeno-associated viral vector-mediated gene transfer of human blood coagulation factor IX in mouse liver. Blood 91 12 (1998) 4600-4607
    • (1998) Blood , vol.91 , Issue.12 , pp. 4600-4607
    • Nakai, H.1    Herzog, R.W.2
  • 26
    • 0041806502 scopus 로고    scopus 로고
    • Looking into the safety of AAV vectors
    • Nakai H., and Kay M. Looking into the safety of AAV vectors. Nature 424 (2003) 251
    • (2003) Nature , vol.424 , pp. 251
    • Nakai, H.1    Kay, M.2
  • 27
    • 0038054338 scopus 로고    scopus 로고
    • AAV serotype 2 vectors preferentially integrate into active genes in mice
    • Nakai H., Montini E., et al. AAV serotype 2 vectors preferentially integrate into active genes in mice. Nat. Genet. 34 3 (2003) 297-302
    • (2003) Nat. Genet. , vol.34 , Issue.3 , pp. 297-302
    • Nakai, H.1    Montini, E.2
  • 28
    • 0033814178 scopus 로고    scopus 로고
    • Recruitment of single-stranded recombinant adeno-associated virus vector genomes and intermolecular recombination are responsible for stable transduction of liver in vivo
    • Nakai H., Storm T.A., et al. Recruitment of single-stranded recombinant adeno-associated virus vector genomes and intermolecular recombination are responsible for stable transduction of liver in vivo. J. Virol. 74 20 (2000) 9451-9463
    • (2000) J. Virol. , vol.74 , Issue.20 , pp. 9451-9463
    • Nakai, H.1    Storm, T.A.2
  • 29
    • 0034960344 scopus 로고    scopus 로고
    • Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo
    • Nakai H., Yant S.R., et al. Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo. J. Virol. 75 15 (2001) 6969-6976
    • (2001) J. Virol. , vol.75 , Issue.15 , pp. 6969-6976
    • Nakai, H.1    Yant, S.R.2
  • 30
    • 0142010650 scopus 로고    scopus 로고
    • Glucose responsive hepatic insulin gene therapy of spontaneously diabetic BB/Wor rats
    • Olson D., Paveglio S., et al. Glucose responsive hepatic insulin gene therapy of spontaneously diabetic BB/Wor rats. Hum. Gene Ther. 14 15 (2003) 1401-1413
    • (2003) Hum. Gene Ther. , vol.14 , Issue.15 , pp. 1401-1413
    • Olson, D.1    Paveglio, S.2
  • 31
    • 0034085607 scopus 로고    scopus 로고
    • Transduction of hepatocellular carcinoma (HCC) using recombinant adeno-associated virus (rAAV): in vitro and in vivo effects of genotoxic agents
    • Peng D., Qian C., et al. Transduction of hepatocellular carcinoma (HCC) using recombinant adeno-associated virus (rAAV): in vitro and in vivo effects of genotoxic agents. J. Hepatol. 32 6 (2000) 975-985
    • (2000) J. Hepatol. , vol.32 , Issue.6 , pp. 975-985
    • Peng, D.1    Qian, C.2
  • 32
    • 20444383143 scopus 로고    scopus 로고
    • Host cells reduce glucose uptake and glycogen deposition in response to hepatic insulin gene therapy
    • Porter M.H., Paveglio S.A., et al. Host cells reduce glucose uptake and glycogen deposition in response to hepatic insulin gene therapy. J. Invest. Med. 53 4 (2005) 201-212
    • (2005) J. Invest. Med. , vol.53 , Issue.4 , pp. 201-212
    • Porter, M.H.1    Paveglio, S.A.2
  • 33
    • 0036314659 scopus 로고    scopus 로고
    • Counteraction of type 1 diabetic alterations by engineering skeletal muscle to produce insulin: insights from transgenic mice
    • Riu E., Mas A., et al. Counteraction of type 1 diabetic alterations by engineering skeletal muscle to produce insulin: insights from transgenic mice. Diabetes 51 3 (2002) 704-711
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 704-711
    • Riu, E.1    Mas, A.2
  • 34
    • 0034008332 scopus 로고    scopus 로고
    • Loss of ATM function enhances recombinant adeno-associated virus transduction and integration through pathways similar to UV irradiation
    • Sanlioglu S., Benson P., et al. Loss of ATM function enhances recombinant adeno-associated virus transduction and integration through pathways similar to UV irradiation. Virology 268 1 (2000) 68-78
    • (2000) Virology , vol.268 , Issue.1 , pp. 68-78
    • Sanlioglu, S.1    Benson, P.2
  • 35
    • 0033105766 scopus 로고    scopus 로고
    • Two independent molecular pathways for recombinant adeno-associated virus genome conversion occur after UV-C and E4orf6 augmentation of transduction
    • Sanlioglu S., Duan D., et al. Two independent molecular pathways for recombinant adeno-associated virus genome conversion occur after UV-C and E4orf6 augmentation of transduction. Hum. Gene Ther. 10 4 (1999) 591-602
    • (1999) Hum. Gene Ther. , vol.10 , Issue.4 , pp. 591-602
    • Sanlioglu, S.1    Duan, D.2
  • 36
    • 33645908797 scopus 로고    scopus 로고
    • Long-term efficacy of adeno-associated virus serotypes 8 and 9 in Hemophilia A dogs and mice
    • Sarkar R., Mucci M., et al. Long-term efficacy of adeno-associated virus serotypes 8 and 9 in Hemophilia A dogs and mice. Hum. Gene Ther. 17 4 (2006) 427-439
    • (2006) Hum. Gene Ther. , vol.17 , Issue.4 , pp. 427-439
    • Sarkar, R.1    Mucci, M.2
  • 37
    • 0029922307 scopus 로고    scopus 로고
    • Synthesis and processing of genetically modified human proinsulin by rat myoblast primary cultures
    • Simonson G.D., Groskreutz D.J., et al. Synthesis and processing of genetically modified human proinsulin by rat myoblast primary cultures. Hum. Gene Ther. 7 (1996) 71-78
    • (1996) Hum. Gene Ther. , vol.7 , pp. 71-78
    • Simonson, G.D.1    Groskreutz, D.J.2
  • 38
    • 17444372024 scopus 로고    scopus 로고
    • Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors
    • Snyder R.O., Miao C., et al. Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors. Nat. Med. 5 1 (1999) 64-70
    • (1999) Nat. Med. , vol.5 , Issue.1 , pp. 64-70
    • Snyder, R.O.1    Miao, C.2
  • 39
    • 0030997346 scopus 로고    scopus 로고
    • Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors
    • Snyder R.O., Miao C.H., et al. Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors. Nat. Genet. 16 (1997) 270-276
    • (1997) Nat. Genet. , vol.16 , pp. 270-276
    • Snyder, R.O.1    Miao, C.H.2
  • 40
    • 0034828903 scopus 로고    scopus 로고
    • Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors
    • Song S., Embury J., et al. Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors. Gene Ther. 8 17 (2001) 1299-1306
    • (2001) Gene Ther. , vol.8 , Issue.17 , pp. 1299-1306
    • Song, S.1    Embury, J.2
  • 41
    • 0026501127 scopus 로고
    • NF-IL-6, a member of the C/EBP family, regulates E1A-responsive promoters in the abscence of E1A
    • Spergel J., Hsu W., et al. NF-IL-6, a member of the C/EBP family, regulates E1A-responsive promoters in the abscence of E1A. J. Virol. 66 2 (1992) 1021-1030
    • (1992) J. Virol. , vol.66 , Issue.2 , pp. 1021-1030
    • Spergel, J.1    Hsu, W.2
  • 42
    • 0026053032 scopus 로고
    • Interleukin 6 enhances a cellular activity that functionally substitutes for E1A protein in transactivation
    • Spergel J.M., and Chen-Kiang S. Interleukin 6 enhances a cellular activity that functionally substitutes for E1A protein in transactivation. Proc. Natl. Acad. Sci. U.S.A. 88 15 (1991) 6472-6476
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , Issue.15 , pp. 6472-6476
    • Spergel, J.M.1    Chen-Kiang, S.2
  • 43
    • 33644876113 scopus 로고    scopus 로고
    • Hepatic insulin gene therapy prevents deterioration of vascular function and improves adipocytokine profile in STZ-diabetic rats 10.1152/ajpendo. 00134. 2005
    • Thule P.M., Campbell A.G., et al. Hepatic insulin gene therapy prevents deterioration of vascular function and improves adipocytokine profile in STZ-diabetic rats 10.1152/ajpendo. 00134. 2005. Am. J. Physiol. Endocrinol. Metab. 290 1 (2006) E114-E122
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.290 , Issue.1
    • Thule, P.M.1    Campbell, A.G.2
  • 44
    • 0034004456 scopus 로고    scopus 로고
    • Glucose regulated production of human insulin in rat hepatocytes
    • Thule P.M., Liu J., et al. Glucose regulated production of human insulin in rat hepatocytes. Gene Ther. 7 3 (2000) 205-214
    • (2000) Gene Ther. , vol.7 , Issue.3 , pp. 205-214
    • Thule, P.M.1    Liu, J.2
  • 45
    • 0033765795 scopus 로고    scopus 로고
    • Regulated hepatic insulin gene therapy of STZ-diabetic rats
    • Thule P.M., and Liu J.M. Regulated hepatic insulin gene therapy of STZ-diabetic rats. Gene Ther. 7 20 (2000) 1744-1752
    • (2000) Gene Ther. , vol.7 , Issue.20 , pp. 1744-1752
    • Thule, P.M.1    Liu, J.M.2
  • 46
    • 0029120870 scopus 로고
    • Rescue and replication signals of the adeno-associated virus 2 genome
    • Wang X.S., Ponnazhagan S., et al. Rescue and replication signals of the adeno-associated virus 2 genome. J. Mol. Biol. 250 5 (1995) 573-580
    • (1995) J. Mol. Biol. , vol.250 , Issue.5 , pp. 573-580
    • Wang, X.S.1    Ponnazhagan, S.2
  • 47
    • 0030030227 scopus 로고    scopus 로고
    • Rescue and replication of adeno-associated virus type 2 as well as vector DNA sequences from recombinant plasmids containing deletions in the viral inverted terminal repeats: selective encapsidation of viral genomes in progeny virions
    • Wang X.S., Ponnazhagan S., et al. Rescue and replication of adeno-associated virus type 2 as well as vector DNA sequences from recombinant plasmids containing deletions in the viral inverted terminal repeats: selective encapsidation of viral genomes in progeny virions. J. Virol. 70 3 (1996) 1668-1677
    • (1996) J. Virol. , vol.70 , Issue.3 , pp. 1668-1677
    • Wang, X.S.1    Ponnazhagan, S.2
  • 48
    • 33750722840 scopus 로고    scopus 로고
    • Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes
    • Wu Z., Asokan A., et al. Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes. J. Virol. 80 22 (2006) 11393-11397
    • (2006) J. Virol. , vol.80 , Issue.22 , pp. 11393-11397
    • Wu, Z.1    Asokan, A.2
  • 49
    • 0031775494 scopus 로고    scopus 로고
    • Adeno-associated virus as a vector for liver-directed gene therapy
    • Xiao W., Berta S.C., et al. Adeno-associated virus as a vector for liver-directed gene therapy. J. Virol. 72 12 (1998) 10222-10226
    • (1998) J. Virol. , vol.72 , Issue.12 , pp. 10222-10226
    • Xiao, W.1    Berta, S.C.2
  • 50
    • 0036171821 scopus 로고    scopus 로고
    • Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors
    • Yan Z., Zak R., et al. Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors. J. Virol. 76 5 (2002) 2043-2053
    • (2002) J. Virol. , vol.76 , Issue.5 , pp. 2043-2053
    • Yan, Z.1    Zak, R.2
  • 51
    • 0028328261 scopus 로고
    • Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
    • Yang Y., Nunes F.A., et al. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. U.S.A. 91 10 (1994) 4407-4411
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , Issue.10 , pp. 4407-4411
    • Yang, Y.1    Nunes, F.A.2
  • 52
    • 0031834034 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated delivery of erythropoietin leads to sustained elevation of hematocrit in nonhuman primates
    • Zhou S., Murphy J.M., et al. Adeno-associated virus-mediated delivery of erythropoietin leads to sustained elevation of hematocrit in nonhuman primates. Gene Ther. 5 (1998) 665-670
    • (1998) Gene Ther. , vol.5 , pp. 665-670
    • Zhou, S.1    Murphy, J.M.2


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