Value of free cortisol measurement in systemic infection

Hormone and Metabolic Research

Volumn 39, Issue 6, 2007, Pages 439-444

  Torpy, D J ^a   Ho, J T ^a  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Free cortisol; Relative adrenal insufficiency (RAI); Septic shock

Indexed keywords

ALBUMIN; BIOLOGICAL MARKER; CORTICOTROPIN; HYDROCORTISONE; NITRIC OXIDE; TETRACOSACTIDE; TRANSCORTIN;

ADRENAL INSUFFICIENCY; BLOOD PRESSURE; CONFERENCE PAPER; CORRELATION ANALYSIS; CRITICAL ILLNESS; DISEASE MARKER; DISEASE SEVERITY; FREE CORTISOL INDEX; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYPERCORTISOLISM; INFECTION; MORTALITY; PRIORITY JOURNAL; PROGNOSIS; SEPSIS; SEPTIC SHOCK; SYSTEMIC DISEASE; TREATMENT INDICATION; TREATMENT RESPONSE;

ADRENOCORTICOTROPIC HORMONE; CARRIER PROTEINS; HUMANS; HYDROCORTISONE; SERUM ALBUMIN; SHOCK, SEPTIC;

EID: 34347258108     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-980200     Document Type: Conference Paper

References (21)

1. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20: 864-874
2. Torpy DJ, Chrousos GP. The three-way interactions between the hypothalamic-pituitary-adrenal and gonadal axes and the immune system. Baillieres Clin Rheumatol 1996; 10: 181-198
3. Cardona ML. Waterhouse-Friderichsen syndrome. Acta Pediatr Esp 1950; 8: 421-429
4. Minneci PC, Deans KJ, Banks SM, Eichacker PQ, Natanson C. Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose. Ann Intern Med 2004; 141: 47-56
5. Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ 2004; 329: 480
6. Bollaert PE. Stress doses of glucocorticoids in catecholamine dependency: a new therapy for a new syndrome? Intensive Care Med 2000; 26: 3-5
7. Briegel J, Forst H, Haller M, Schelling G, Kilger E, Kuprat G, Hemmer B, Hummel T, Lenhart A, Heyduck M, Stoll C, Peter K. Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Crit Care Med 1999; 27: 723-732
8. Sam S, Corbridge TC, Mokhlesi B, Comellas AP, Molitch ME. Cortisol levels and mortality in severe sepsis. Clin Endocrinol (Oxf) 2004; 60: 29-35
9. Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troche G, Chaumet-Riffaut P, Bellissant E. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002; 288: 862-871
10. Rothwell PM, Udwadia ZF, Lawler PG. Cortisol response to corticotropin and survival in septic shock. Lancet 1991; 337: 582-583
11. Annane D, Sebille V, Troche G, Raphael JC, Gajdos P, Bellissant E. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000; 283: 1038-1045
12. Annane D, Bellissant E, Sebille V, Lesieur O, Mathieu B, Raphael JC, Gajdos P. Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve. Br J Clin Pharmacol 1998; 46: 589-597
13. Emptoz-Bonneton A, Crave JC, Lejeune H, Brebant C, Pugeat M. Corticosteroid-binding globulin synthesis regulation by cytokines and glucocorticoids in human hepatoblastoma-derived (HepG2) cells. J Clin Endocrinol Metab 1997; 82: 3758-3762
14. Hammond GL, Smith CL, Paterson NA, Sibbald WJ. A role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils. J Clin Endocrinol Metab 1990; 71: 34-39
15. Hamrahian AH, Oseni TS, Arafah BM. Measurements of serum free cortisol in critically ill patients. N Engl J Med 2004; 350: 1629-1638
16. Beishuizen A, Thijs LG. Relative adrenal failure in intensive care: an identifiable problem requiring treatment? Best Pract Res Clin Endocrinol Metab 2001; 15: 513-531
17. Marik PE, Zaloga GP. Adrenal insufficiency in the critically ill: a new look at an old problem. Chest 2002; 122: 1784-1796
18. Coolens JL, Van BH, Heyns W. Clinical use of unbound plasma cortisol as calculated from total cortisol and corticosteroid-binding globulin. J Steroid Biochem 1987; 26: 197-202
19. Ho JT, Al-Musalhi H, Chapman MJ, Quach T, Thomas PD, Bagley CJ, Lewis JG, Torpy DJ. Septic shock and sepsis: a comparison of total and free plasma cortisol levels. J Clin Endocrinol Metab 2006; 91: 105-114
20. Keh D, Boehnke T, Weber-Cartens S, Schulz C, Ahlers O, Bercker S, Volk HD, Doecke WD, Falke KJ, Gerlach H. Immunologic and hemodynamic effects of "low-dose" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study. Am J Respir Crit Care Med 2003; 167: 512-520
21. Confalonieri M, Urbino R, Potena A, Piattella M, Parigi P, Puccio G, Della PR, Giorgio C, Blasi F, Umberger R, Meduri GU. Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. Am J Respir Crit Care Med 2005; 171: 242-248