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Volumn 67, Issue 11, 2007, Pages 5308-5317

Protein kinase CA determines HER2 fate in breast carcinoma cells with HER2 protein overexpression without gene amplification

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; LAPATINIB; PROTEIN KINASE C ALPHA; PROTEIN TYROSINE KINASE INHIBITOR; SMALL INTERFERING RNA; UBIQUITIN; 12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; CARBAZOLE DERIVATIVE; CBL PROTEIN; CBL PROTEIN, HUMAN; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR; INDOLE DERIVATIVE; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 34347226346     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-3936     Document Type: Article
Times cited : (32)

References (47)
  • 2
    • 0034638925 scopus 로고    scopus 로고
    • Molecular mechanisms underlying ErbB2/HER2 action in breast cancer
    • Harari D, Yarden Y. Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. Oncogene 2000;19:6102-14.
    • (2000) Oncogene , vol.19 , pp. 6102-6114
    • Harari, D.1    Yarden, Y.2
  • 3
    • 0041572902 scopus 로고    scopus 로고
    • Role of HER2 in wound-induced breast carcinoma proliferation
    • Tagliabue E, Agresti R, Carcangiu ML, et al. Role of HER2 in wound-induced breast carcinoma proliferation. Lancet 2003;362:527-33.
    • (2003) Lancet , vol.362 , pp. 527-533
    • Tagliabue, E.1    Agresti, R.2    Carcangiu, M.L.3
  • 4
    • 0032961052 scopus 로고    scopus 로고
    • c-erbB2/neu gene and chromosome 17 analysis in breast cancer by FISH on archival cytological fine-needle aspirates
    • Mezzelani A, Alasio L, Bartoli C, et al. c-erbB2/neu gene and chromosome 17 analysis in breast cancer by FISH on archival cytological fine-needle aspirates. Br J Cancer 1999;80:519-25.
    • (1999) Br J Cancer , vol.80 , pp. 519-525
    • Mezzelani, A.1    Alasio, L.2    Bartoli, C.3
  • 5
    • 0036184773 scopus 로고    scopus 로고
    • HER2-positive breast carcinomas as a particular subset with peculiar clinical behaviors
    • Ménard S, Balsari A, Casalini P, et al. HER2-positive breast carcinomas as a particular subset with peculiar clinical behaviors. Clin Cancer Res 2002;8:520-5.
    • (2002) Clin Cancer Res , vol.8 , pp. 520-525
    • Ménard, S.1    Balsari, A.2    Casalini, P.3
  • 6
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraitsof human breast tumours
    • Perou CM, Sorlie T, Eisen MB, et al. Molecular portraitsof human breast tumours. Nature 2000;406:747-52.
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 7
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • Van'T Veer LJ, Dai H, Van de Vijver MJ, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002;415:530-6.
    • (2002) Nature , vol.415 , pp. 530-536
    • Van'T Veer, L.J.1    Dai, H.2    Van de Vijver, M.J.3
  • 8
    • 0037429779 scopus 로고    scopus 로고
    • The deaf and the dumb: The biology of ErbB-2 and ErbB-3
    • Citri A, Skaria KB, Yarden Y. The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res 2003;284:54-65.
    • (2003) Exp Cell Res , vol.284 , pp. 54-65
    • Citri, A.1    Skaria, K.B.2    Yarden, Y.3
  • 9
    • 32944461545 scopus 로고    scopus 로고
    • Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
    • Konecny GE, Pegram MD, Venkatesan N, et al. Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells. Cancer Res 2006;66:1630-9.
    • (2006) Cancer Res , vol.66 , pp. 1630-1639
    • Konecny, G.E.1    Pegram, M.D.2    Venkatesan, N.3
  • 10
    • 33645845151 scopus 로고    scopus 로고
    • Protein kinase C (PKC) family in cancer progression
    • Koivunen J, Aaltonen V, Peltonen J. Protein kinase C (PKC) family in cancer progression. Cancer Lett 2006;235:1-10.
    • (2006) Cancer Lett , vol.235 , pp. 1-10
    • Koivunen, J.1    Aaltonen, V.2    Peltonen, J.3
  • 11
    • 0028903545 scopus 로고
    • MCF-7 breast cancer cells transfected with protein kinase C-α exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype
    • Ways DK, Kukoly CA, deVente J, et al. MCF-7 breast cancer cells transfected with protein kinase C-α exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype. J Clin Invest 1995;95:1906-15.
    • (1995) J Clin Invest , vol.95 , pp. 1906-1915
    • Ways, D.K.1    Kukoly, C.A.2    deVente, J.3
  • 12
    • 0035354188 scopus 로고    scopus 로고
    • Protein kinase Cα and protein kinase Cδ play opposite roles in the proliferation and apoptosis of glioma cells
    • Mandil R, Ashkenazi E, Blass M, et al. Protein kinase Cα and protein kinase Cδ play opposite roles in the proliferation and apoptosis of glioma cells. Cancer Res 2001;61:4612-9.
    • (2001) Cancer Res , vol.61 , pp. 4612-4619
    • Mandil, R.1    Ashkenazi, E.2    Blass, M.3
  • 13
    • 0040951308 scopus 로고    scopus 로고
    • Membrane targeting and cytoplasmic sequestration in the spatiotemporal localization of human protein kinase Cα
    • Vallentin A, Prevostel C, Fauquier T, Bonnefont X, Joubert D. Membrane targeting and cytoplasmic sequestration in the spatiotemporal localization of human protein kinase Cα. J Biol Chem 2000;275:6014-21.
    • (2000) J Biol Chem , vol.275 , pp. 6014-6021
    • Vallentin, A.1    Prevostel, C.2    Fauquier, T.3    Bonnefont, X.4    Joubert, D.5
  • 14
    • 10044298444 scopus 로고    scopus 로고
    • The link between PKCα regulation and cellular transformation
    • Michie AM, Nakagawa R. The link between PKCα regulation and cellular transformation. Immunol Lett 2005;96:155-62.
    • (2005) Immunol Lett , vol.96 , pp. 155-162
    • Michie, A.M.1    Nakagawa, R.2
  • 15
    • 0034714277 scopus 로고    scopus 로고
    • Threonine phosphorylation diverts internalized epidermal growth factor receptorsfrom a degradative pathway to the recycling endosome
    • Bao J, Alroy I, Waterman H, et al. Threonine phosphorylation diverts internalized epidermal growth factor receptorsfrom a degradative pathway to the recycling endosome. J Biol Chem 2000;275:26178-86.
    • (2000) J Biol Chem , vol.275 , pp. 26178-26186
    • Bao, J.1    Alroy, I.2    Waterman, H.3
  • 16
    • 0036141363 scopus 로고    scopus 로고
    • A formalin-fixed, paraffin-processed cell line standard for quality control of immunohistochemical assay of HER-2/neu expression in breast cancer
    • Rhodes A, Jasani B, Couturier J, et al. A formalin-fixed, paraffin-processed cell line standard for quality control of immunohistochemical assay of HER-2/neu expression in breast cancer. Am J Clin Pathol 2002;117:81-9.
    • (2002) Am J Clin Pathol , vol.117 , pp. 81-89
    • Rhodes, A.1    Jasani, B.2    Couturier, J.3
  • 17
    • 0025752933 scopus 로고
    • Selection of monoclonal antibodies which induce internalization and phosphorylation of p185HER2 and growth inhibition of cells with HER2/neu gene amplification
    • Tagliabue E, Centis F, Campiglio M, et al. Selection of monoclonal antibodies which induce internalization and phosphorylation of p185HER2 and growth inhibition of cells with HER2/neu gene amplification. Int J Cancer 1991;47:933-7.
    • (1991) Int J Cancer , vol.47 , pp. 933-937
    • Tagliabue, E.1    Centis, F.2    Campiglio, M.3
  • 18
    • 0035241668 scopus 로고    scopus 로고
    • Improvementsi n cytogenetic slide preparation: Controlled chromosome spreading, chemical aging and gradual denaturing
    • Henegariu O, Heerema NA, Lowe WL, Bray-Ward P, Ward DC, Vance GH. Improvementsi n cytogenetic slide preparation: controlled chromosome spreading, chemical aging and gradual denaturing. Cytometry 2001;43:101-9.
    • (2001) Cytometry , vol.43 , pp. 101-109
    • Henegariu, O.1    Heerema, N.A.2    Lowe, W.L.3    Bray-Ward, P.4    Ward, D.C.5    Vance, G.H.6
  • 19
    • 0037998712 scopus 로고    scopus 로고
    • HER-2/neu assessment in primary chemotherapy treated breast carcinoma: No evidence of gene profile changing
    • Dagrada GP, Mezzelani A, Alasio L, et al. HER-2/neu assessment in primary chemotherapy treated breast carcinoma: no evidence of gene profile changing. Breast Cancer Res Treat 2003;80:207-14.
    • (2003) Breast Cancer Res Treat , vol.80 , pp. 207-214
    • Dagrada, G.P.1    Mezzelani, A.2    Alasio, L.3
  • 20
    • 33846276917 scopus 로고    scopus 로고
    • Radiation effectson development of HER2-positive breast carcinomas
    • Castiglioni F, Terenziani M, Carcangiu ML, et al. Radiation effectson development of HER2-positive breast carcinomas. Clin Cancer Res 2007;13:46-51.
    • (2007) Clin Cancer Res , vol.13 , pp. 46-51
    • Castiglioni, F.1    Terenziani, M.2    Carcangiu, M.L.3
  • 22
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:e45.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 23
    • 0029778177 scopus 로고    scopus 로고
    • Role of c-Src tyrosine kinase in G protein-coupled receptor- and Ghγ subunit-mediated activation of mitogen-activated protein kinases
    • Luttrell LM, Hawes BE, Van Biesen T, Luttrell DK, Lansing TJ, Lefkowitz RJ. Role of c-Src tyrosine kinase in G protein-coupled receptor- and Ghγ subunit-mediated activation of mitogen-activated protein kinases. J Biol Chem 1996;271:19443-50.
    • (1996) J Biol Chem , vol.271 , pp. 19443-19450
    • Luttrell, L.M.1    Hawes, B.E.2    Van Biesen, T.3    Luttrell, D.K.4    Lansing, T.J.5    Lefkowitz, R.J.6
  • 25
    • 0033392493 scopus 로고    scopus 로고
    • Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
    • Levkowitz G, Waterman H, Ettenberg SA, et al. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell 1999;4:1029-40.
    • (1999) Mol Cell , vol.4 , pp. 1029-1040
    • Levkowitz, G.1    Waterman, H.2    Ettenberg, S.A.3
  • 26
    • 0034634678 scopus 로고    scopus 로고
    • c-Cbl isa suppressor of the neu oncogene
    • Levkowitz G, Oved S, Klapper LN, et al. c-Cbl isa suppressor of the neu oncogene. J Biol Chem 2000;275:35532-9.
    • (2000) J Biol Chem , vol.275 , pp. 35532-35539
    • Levkowitz, G.1    Oved, S.2    Klapper, L.N.3
  • 27
    • 0037151034 scopus 로고    scopus 로고
    • Mechanism of 17-β-estradiol- induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-δ
    • Keshamouni VG, Mattingly RR, Reddy KB. Mechanism of 17-β-estradiol- induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-δ. J Biol Chem 2002;277:22558-65.
    • (2002) J Biol Chem , vol.277 , pp. 22558-22565
    • Keshamouni, V.G.1    Mattingly, R.R.2    Reddy, K.B.3
  • 28
    • 0028907508 scopus 로고
    • Protein kinase C and phospholipase D activation in rat parotid glands
    • Guillemain I, Rossignol B. Protein kinase C and phospholipase D activation in rat parotid glands. FEBS Lett 1995;363:13-6.
    • (1995) FEBS Lett , vol.363 , pp. 13-16
    • Guillemain, I.1    Rossignol, B.2
  • 29
    • 0038444776 scopus 로고    scopus 로고
    • Protein kinase Cα negatively regulates cell spreading and motility in MDA-MB-231 human breast cancer cells downstream of epidermal growth factor receptor
    • Gauthier ML, Torretto C, Ly J, Francescutti V, O'Day DH. Protein kinase Cα negatively regulates cell spreading and motility in MDA-MB-231 human breast cancer cells downstream of epidermal growth factor receptor. Biochem Biophys Res Commun 2003;307:839-46.
    • (2003) Biochem Biophys Res Commun , vol.307 , pp. 839-846
    • Gauthier, M.L.1    Torretto, C.2    Ly, J.3    Francescutti, V.4    O'Day, D.H.5
  • 30
    • 0036789884 scopus 로고    scopus 로고
    • Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu
    • Xu W, Marcu M, Yuan X, Mimnaugh E, Patterson C, Neckers L. Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu. Proc Natl Acad Sci U S A 2002;99:12847-52.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12847-12852
    • Xu, W.1    Marcu, M.2    Yuan, X.3    Mimnaugh, E.4    Patterson, C.5    Neckers, L.6
  • 31
    • 0029917264 scopus 로고    scopus 로고
    • Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins
    • Levkowitz G, Klapper LN, Tzahar E, Freywald A, Sela M, Yarden Y. Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins. Oncogene 1996;12:1117-25.
    • (1996) Oncogene , vol.12 , pp. 1117-1125
    • Levkowitz, G.1    Klapper, L.N.2    Tzahar, E.3    Freywald, A.4    Sela, M.5    Yarden, Y.6
  • 32
    • 1842591231 scopus 로고    scopus 로고
    • Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases
    • Marmor MD, Yarden Y. Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases. Oncogene 2004;23:2057-70.
    • (2004) Oncogene , vol.23 , pp. 2057-2070
    • Marmor, M.D.1    Yarden, Y.2
  • 33
    • 1642422374 scopus 로고    scopus 로고
    • Association with membrane protrusions makes ErbB2 an internalization-resistant receptor
    • Hommelgaard AM, Lerdrup M, van Deurs B. Association with membrane protrusions makes ErbB2 an internalization-resistant receptor. Mol Biol Cell 2004;15:1557-67.
    • (2004) Mol Biol Cell , vol.15 , pp. 1557-1567
    • Hommelgaard, A.M.1    Lerdrup, M.2    van Deurs, B.3
  • 34
    • 13644268540 scopus 로고    scopus 로고
    • Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells
    • Round JL, Tomassian T, Zhang M, Patel V, Schoenberger SP, Miceli MC. Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells. J Exp Med 2005;201:419-30.
    • (2005) J Exp Med , vol.201 , pp. 419-430
    • Round, J.L.1    Tomassian, T.2    Zhang, M.3    Patel, V.4    Schoenberger, S.P.5    Miceli, M.C.6
  • 35
    • 0033858056 scopus 로고    scopus 로고
    • Protein kinase C(α) actively downregulates through caveolae-dependent traffic to an endosomal compartment
    • Prevostel C, Alice V, Joubert D, Parker PJ. Protein kinase C(α) actively downregulates through caveolae-dependent traffic to an endosomal compartment. J Cell Sci 2000;113:2575-84.
    • (2000) J Cell Sci , vol.113 , pp. 2575-2584
    • Prevostel, C.1    Alice, V.2    Joubert, D.3    Parker, P.J.4
  • 36
    • 0030731231 scopus 로고    scopus 로고
    • Interaction of a receptor tyrosine kinase, EGF-R, with caveolins - caveolin binding negatively regulatesty rosine and serine/threonine kinase activities
    • Couet J, Sargiacomo M, Lisanti MP. Interaction of a receptor tyrosine kinase, EGF-R, with caveolins - caveolin binding negatively regulatesty rosine and serine/threonine kinase activities. J Biol Chem 1997;272:30429-38.
    • (1997) J Biol Chem , vol.272 , pp. 30429-30438
    • Couet, J.1    Sargiacomo, M.2    Lisanti, M.P.3
  • 37
  • 38
    • 0035853045 scopus 로고    scopus 로고
    • Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon IgE-triggered cell signaling
    • Lafont F, Simons K. Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon IgE-triggered cell signaling. Proc Natl Acad Sci U S A 2001;98:3180-4.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 3180-3184
    • Lafont, F.1    Simons, K.2
  • 39
    • 14544306526 scopus 로고    scopus 로고
    • Clathrin-independent endocytosis of ubiquitinated cargos
    • Sigismund S, Woelk T, Puri C, et al. Clathrin-independent endocytosis of ubiquitinated cargos. Proc Natl Acad Sci U S A 2005;102:2760-5.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 2760-2765
    • Sigismund, S.1    Woelk, T.2    Puri, C.3
  • 40
    • 14544295742 scopus 로고    scopus 로고
    • Endocytosis of membrane receptors: Two pathways are better than one
    • Aguilar RC, Wendland B. Endocytosis of membrane receptors: two pathways are better than one. Proc Natl Acad Sci U S A 2005;102:2679-80.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 2679-2680
    • Aguilar, R.C.1    Wendland, B.2
  • 42
    • 9444252957 scopus 로고    scopus 로고
    • Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin
    • Austin CD, De Maziere AM, Pisacane PI, et al. Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin. Mol Biol Cell 2004;15:5268-82.
    • (2004) Mol Biol Cell , vol.15 , pp. 5268-5282
    • Austin, C.D.1    De Maziere, A.M.2    Pisacane, P.I.3
  • 43
    • 0141844576 scopus 로고    scopus 로고
    • Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor
    • Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ , Wiedmer T. Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor. J Biol Chem 2003;278:37413-8.
    • (2003) J Biol Chem , vol.278 , pp. 37413-37418
    • Nanjundan, M.1    Sun, J.2    Zhao, J.3    Zhou, Q.4    Sims, P.J.5    Wiedmer, T.6
  • 44
    • 33744936606 scopus 로고    scopus 로고
    • Upregulation and activation of PKCα by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKCα and Src inhibitors
    • Tan M, Li P, Sun M, Yin G, Yu D. Upregulation and activation of PKCα by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKCα and Src inhibitors. Oncogene 2006;25:3286-95.
    • (2006) Oncogene , vol.25 , pp. 3286-3295
    • Tan, M.1    Li, P.2    Sun, M.3    Yin, G.4    Yu, D.5
  • 45
    • 0242290342 scopus 로고    scopus 로고
    • WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation
    • Magnifico A, Ettenberg S, Yang C, et al. WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation. J Biol Chem 2003;278:43169-77.
    • (2003) J Biol Chem , vol.278 , pp. 43169-43177
    • Magnifico, A.1    Ettenberg, S.2    Yang, C.3
  • 46
    • 0035920225 scopus 로고    scopus 로고
    • Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex
    • Ettenberg SA, Magnifico A, Cuello M, et al. Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex. J Biol Chem 2001;276:27677-84.
    • (2001) J Biol Chem , vol.276 , pp. 27677-27684
    • Ettenberg, S.A.1    Magnifico, A.2    Cuello, M.3
  • 47
    • 32344451150 scopus 로고    scopus 로고
    • Regulating the regulator: Negative regulation of Cbl ubiquitin ligases
    • Ryan PE, Davies GC, Nau MM, Lipkowitz S. Regulating the regulator: negative regulation of Cbl ubiquitin ligases. Trends Biochem Sci 2006;31:79-88.
    • (2006) Trends Biochem Sci , vol.31 , pp. 79-88
    • Ryan, P.E.1    Davies, G.C.2    Nau, M.M.3    Lipkowitz, S.4


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