Heat shock proteins and innate immunity

Clinical and Experimental Immunology

Volumn 127, Issue 1, 2002, Pages 1-3

  Gaston, J S H ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Heat shock proteins; Innate immunity; LPS; Toll like receptors

Indexed keywords

ANTIGEN; CHAPERONE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HYBRID PROTEIN; TUMOR ANTIGEN;

AMINO ACID SEQUENCE; ANTIBODY RESPONSE; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; AUTOIMMUNE DISEASE; BONE MARROW CELL; CELL INTERACTION; CELL STIMULATION; CELLULAR IMMUNITY; CROSS REACTION; ENDOTHELIUM CELL; HUMAN; HUMORAL IMMUNITY; IMMUNOGENICITY; INFLAMMATION; MYCOBACTERIUM; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TARGETING; REVIEW;

HEAT-SHOCK PROTEINS; HUMANS; IMMUNITY, NATURAL;

EID: 0036179002     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2002.01759.x     Document Type: Review

References (28)

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2. Induction of diabetes in standard mice by immunization with the p277 peptide of a 60-kDa heat shock protein
3. T cell recognition of stress proteins. A link between infectious and autoimmune disease
4. Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis
5. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity
6. Heat shock proteins come of age: Primitive functions acquire new roles in an adaptive world
7. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin
8. A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins
9. In vivo cytotoxic T lymphocyte elicitation by mycobacterial heat shock protein 70 fusion proteins maps to a discrete domain and is CD4 (+) T cell independent
10. C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
11. Mycobacterial 65-kD heat shock protein induces release of proinflammatory cytokines from human monocytic cells
12. Homogeneous Escherichia coli chaperonin 60 induces IL-1 beta and IL-6 gene expression in human monocytes by a mechanism independent of protein conformation
13. Human 60-kDa heat-shock protein: A danger signal to the innate immune system
14. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages
15. Cutting edge: Heat shock protein (HSP) 60 activates the innate immune response. CD14 is an essential receptor for HSP60 activation of mononuclear cells
16. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
17. Self-heat shock protein 60 induces tumor necrosis factor-α in monocyte-derived macrophages: Possible role in chronic inflammatory periodontal disease
18. Differential roles of TLR2 and TLR4 in recognition of gram- negative and gram-positive bacterial cell wall components
19. Toll meets bacterial CpG-DNA
20. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
21. Recognition of double-stranded RNA and activation of NF-kB by Toll-like receptor 3
22. Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the Toll/interleukin-1 receptor signaling pathway in innate immune cells
23. Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4
24. Heat shock proteins as 'danger signals': Eukaryotic Hsp60 enhances and accelerates antigen-specific IFN-gamma production in T cells
25. Heat shock protein 65 induces CD62e, CD106, and CD54 on cultured human endothelial cells and increases their adhesiveness for monocytes and granulocytes
26. Molecular chaperones stimulate bone resorption
27. The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor
28. Cutting edge. Heat shock protein gp96 induces maturation and migration of CD11c (+) cells in vivo