A novel crystallization-induced diastereomeric transformation based on a reversible carbon-sulfur bond formation. Application to the synthesis of a γ-secretase inhibitor

Journal of Organic Chemistry

Volumn 72, Issue 13, 2007, Pages 4864-4871

  Davies, Antony J ^a   Scott, Jeremy P ^a   Bishop, Brian C ^a   Brands, Karel M J ^a   Brewer, Sarah E ^a   DaSilva, Jimmy O ^b   Dormer, Peter G ^b   Dolling, Ulf H ^b   Gibb, Andrew D ^a   Hammond, Deborah C ^a   Lieberman, David R ^a   Palucki, Michael ^b   Payack, Joseph F ^b  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; CHEMICAL BONDS; CRYSTALLIZATION; ENZYME INHIBITION; SYNTHESIS (CHEMICAL);

ACIDIC CONDITIONS; BENZYLIC ALCOHOLS; CRYSTALLIZATION-DRIVEN TRANSFORMATION;

PHASE TRANSITIONS;

CARBON; GAMMA SECRETASE INHIBITOR; SULFUR;

ARTICLE; CHEMICAL BOND; CRYSTALLIZATION; DIASTEREOISOMER; DRUG SYNTHESIS;

AMYLOID PRECURSOR PROTEIN SECRETASES; CARBON; CRYSTALLIZATION; FLUORINE; KETO ACIDS; MAGNESIUM; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PROTEASE INHIBITORS; SOLUBILITY; STEREOISOMERISM; SULFIDES; SULFUR; TEMPERATURE;

EID: 34347216384     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0705925     Document Type: Article

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