Crystallization-induced asymmetric transformation: Stereospecific synthesis of L-768,673

Tetrahedron

Volumn 55, Issue 4, 1999, Pages 909-918

  Yao Jun, Shi ^a   Wells, Kenneth M ^a   Pye, Philip J ^a   Choi, Woo Baeg ^a   Churchill, Hywyn R O ^a   Lynch, Joseph E ^a   Maliakal, Ashok ^a   Sager, Jess W ^a   Rossen, Kai ^a   Volante, R P ^a   Reider, Paul J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Asymmetric synthesis; Benzodiazepines; Oximes; Resolution racemization

Indexed keywords

ANTIARRHYTHMIC AGENT; BENZENE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; L 768 673; OXIME; PHENYLACETIC ACID; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CRYSTALLIZATION; DRUG PURITY; DRUG SYNTHESIS; HYDROGENATION; PRIORITY JOURNAL; STEREOCHEMISTRY;

EID: 0033593248     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(98)01098-9     Document Type: Article

References (32)

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32. Performance-based exposure control limit(s) (PB-ECL) - An assigned health hazard category by Merck, within five category classification system of increasing hazard potential, which also defines the level of containment required to control exposure to an acceptable level based upon the inherent pharmacological and toxicological properties of the compound. A level-4 compound, such as 1, is restricted to glove box handling due to its potency.