Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C

Journal of Biological Chemistry

Volumn 271, Issue 29, 1996, Pages 17267-17274

  Pisegna, Joseph R ^a,b   Wank, Stephen A ^a,c  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; INOSITOL PHOSPHATE; PHOSPHOLIPASE C;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; DNA LIBRARY; DNA SEQUENCE; ENZYME ACTIVATION; EXON; HUMAN; HUMAN TISSUE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR GENE; SECOND MESSENGER; SIGNAL TRANSDUCTION;

3T3 CELLS; ADENYLATE CYCLASE; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DNA PRIMERS; EXONS; HUMANS; INOSITOL PHOSPHATES; KINETICS; MICE; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; PHOSPHOLIPASE C; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; PITUITARY GLAND; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTORS, PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE, TYPE I; RECOMBINANT PROTEINS; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION; TRANSFECTION; VARIATION (GENETICS);

EID: 0030035113     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.29.17267     Document Type: Article

References (50)

1. Miyata, A., Arimura, A., Dabl, R. R., Minamino, N., Uehara, A., Jiang, L., Culler, M. D., and Coy, D. H. (1989) Biochem. Biophys. Res. Commun. 164, 567-574
2. Lam, H.-C., Takahashi, K., Ghatei, M. A., Kanse, S. M., Polak, J. M., and Bloom, S. R. (1990) Eur. J. Biochem. 193, 725-729
3. Shivers, B. D., Gores, T. J., Gottschall, P. E., and Arimura, A. (1991) Endocrinology 128, 3055-3065
4. Ishihara, T., Shigemoto, R., Mori, K., Takahashi, K., and Nagata, S. (1992) Neuron 8, 811-819
5. Pisegna, J. R., and Wank, S. A. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6345-6349
6. Lutz, E. M., Sheward, W. J., West, K. M., Morrow, J. A., Fink, G., and Harmar, A. J. (1993) FEBS Lett. 334, 3-8
7. Suda, K., Smith, D. M., Ghatei, M. A., Murphy, J. K., and Bloom, S. R. (1991) J. Clin. Endocrinol. & Metab. 72, 958-964
8. Christophe, J. (1993) Biochim. Biophys. Acta 1154, 183-199
9. Shen, Z., Larsson, L. T., Malmfors, G., Absood, A., Hakanson, R., and Sundler, F. (1992) Cell Tissue Res. 269, 369-374
10. Moody, T. W., Zia, F., and Makheja, L. (1993) Peptides (Elmsford) 14, 241-246
11. Hoshino, M., Li, M., Zheng, L.-Q., Suzuki, M., Iguschi, K., Yanaihara, C., Mochizuki, T., and Yanaihara, N. (1993) International Symposium on Vasoactive Intestinal Peptide, Pituitary Adenylate Cyclase Activating Polypeptide and Related Regulatory Peptides, pp. 577-586, World Scientific Publishing Co., River Edge, NJ
12. Spengler, D., Waeber, C., Pantaloni, C., Holsboer, F., Bockaert, J., Seeburg, P. H., and Journot, L. (1993) Nature 365, 170-175
13. Schomerus, E., Poch, A., Bunting, R., Mason, W. T., and McArdle, C. A. (1994) Endocrinology 134, 315-323
14. Deutsch, P. J., and Sun, Y. (1992) J. Biol. Chem. 267, 5108-5113
15. Takebe, Y., Seiki, M., Fujisawa, J.-I., Hoy, P., Yokota, K., Arai, K.-I., Yoshida, M., and Arai, N. (1988) Mol. Cell. Biol. 8, 466-472
16. Barnes, W. A. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 2216-2220
17. Munson, P. J., and Rodbard, D. (1980) Anal. Biochem. 107, 220-229
18. Varrault, A., Journot, L., Audigier, Y., and Bockaert, J. (1992) Mol. Pharmacol. 41, 999-1007
19. Salomon, Y., Londos, C., and Rodbell, M. (1974) Anal. Biochem. 58, 541-548
20. Berridge, M. J., Dawson, R. M., Downes, C. P., Heslop, J. P., and Irvine, R. F. (1983) Biochem. J. 212, 473-482
21. Wank, S. A., Pisegna, J. R., and deWeerth, A. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 8691-8695
22. Kyte, J., and Doolittle, H. F. (1982) J. Mol. Biol. 157, 105-132
23. von Heijne, G. (1986) Nucleic Acids Res. 14, 4683-4690
24. Ishihara, T., Nakamura, S., Kaziro, Y., Takahashi, T., Takahashi, K., and Nagata, S. (1991) EMBO J. 10, 1635-1641
25. Jelinek, L. J., Lok, S., Rosenberg, G. B., Smith, R. A., Grant, F. J. Biggs, S., Bensch, P. A., Kuijper, J. L., Sheppard, P. O., and Sprecher, C. A. (1993) Science 259, 1614-1616
26. Holtmann, M. H., Hadac, E. M., and Miller, L. J. (1995) J. Biol. Chem. 270, 14394-14398
27. Godfrey, P., Rahal, J. O., Beamer, W. G., Copeland, N. G., Jenkins, N. A., and Mayo, K. E. (1993) Nat. Genet. 4, 227-232
28. Hager, J., Hansen, L., Vaisse, C., Vionnet, N., Philippi, A., Poller, W., Velho, G., Carcassi, C., Contu, L., Julier, C., Cambien, F., Passa, P., Lathrop, M., Kindsvogel, W., Demenais, F., Nishimura, E., and Froguel, P. (1995) Nat. Genet. 9, 299-304
29. Thorens, B. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 8641-8645
30. Chochola, J., Fabre, C., Bellan, C., Luis, J., Bourgerie, S., Abadie, B., Champion, S., Marvaldi, J., and el Battari, A. (1993) J. Biol. Chem. 268, 2312-2318
31. Kusui, T., Benya, R. V., Battey, J. F., and Jensen, R. T. (1994) Biochemistry 33, 12968-12980
32. Karnik, S. S., Sakmann, J. P., Chen, H. A., and Khorana, G. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 8459-8463
33. Ogi, K., Miyamoto, Y., Masuda, Y., Habata, Y., Hosoya, M., Ohtaki, T., Masuo, Y., Onda, H., and Fujino, M. (1993) Biochem. Biophys. Res. Commun. 196, 1511-1521
34. Mount, S. M. (1982) Nucleic Acids Res. 10, 459-472
35. Koch, B., and Lutz-Bucher, B. (1992) Regul. Pept. 38, 45-53
36. Robberecht, P., Woussen-Colle, M.-C., DeNeef, P., Gourlet, P., Buscail, L., Vandermeers, A., Vandermeers-Piret, M.-C., and Cristophe, J. (1991) FEBS Lett. 286, 133-136
37. Hoshino, M., Li, M., Zheng, L. Q., Suzuki, M., Mochizuki, T., and Yanaihara, N. (1993) Neurosci. Lett. 159, 35-38
38. Zhu, X., Gilbert, S., Birnbaumer, M., and Birnbaumer, L. (1994) Mol. Pharmacol. 46, 460-469
39. Chabre, O., Conklin, B. R., Brandon, S., Bourne, H. R., and Limbird, L. E. (1994) J. Biol. Chem. 269, 5730-5734
40. Offermanns, S., Wieland, T., Homann, D., Sandmann, J., Bombien, E., Spicher, K., Schultz, G., and Jakobs, K. H. (1994) Mol. Pharmacol. 45, 890-898
41. Allgeier, A., Offermanns, S., Van Sande, J., Spicher, K., Schultz, G., and Dumont, J. E. (1994) J. Biol. Chem. 269, 13733-13735
42. Chabre, O., Conklin, B. R., Brandon, S., Bourne, H. R., and Limbird, L. E. (1994) J. Biol. Chem. 269, 5730-5734
43. Montmayeur, J.-P., Guiramand, J., and Borrelli, E. (1993) Mol. Endocrinol. 7, 161-170
44. Offermanns, S., Heiler, E., Spicher, K., and Schultz, G. (1994) FEBS Lett. 349, 201-204
45. Rawlings, S. R., Piuz, I., Schlegel, W., Bockaert, J., and Journot, L. (1995) Endocrinology 136, 2088-2098
46. Pandya, P. K., Huang, S. C., Talkad, V. D., Wank, S. A., and Gardner, J. D. (1994) Biochim. Biophys. Acta 1224, 117-126
47. Schworer, H., Katsoulis, S., Creutzfeldt, W., and Schmidt, W. E. (1992) Naunyn-Schmiedebergs Arch. Pharmakol. 346, 511-515
48. Yada, T., Sakurada, M., Ihida, K., Nakata, M., Murata, F., Arimura, A., and Kikuchi, M. (1994) J. Biol. Chem. 269, 1290-1293
49. Isobe, K., Nakai, T., and Takuwa, Y. (1993) Endocrinology 132, 1757-1765
50. Murthy, K. S., and Makhlouf, G. M. (1994) J. Biol. Chem. 269, 15977-15980