메뉴 건너뛰기




Volumn 50, Issue 1, 2007, Pages 204-211

Microvascular dysfunction: A potential pathophysiological role in the metabolic syndrome

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ENDOTHELIN 1; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 34250901935     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.107.089680     Document Type: Conference Paper
Times cited : (195)

References (56)
  • 1
    • 0842277242 scopus 로고    scopus 로고
    • Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/Am Heart Association conference on scientific issues related to definition. Circulation. 2004;109:433-438.
    • Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/Am Heart Association conference on scientific issues related to definition. Circulation. 2004;109:433-438.
  • 5
    • 0035569049 scopus 로고    scopus 로고
    • Impaired skin capillary recruitment in essential hypertension is caused by both functional and structural capillary rarefaction
    • Serné EH, Gans RO, ter Maaten JC, Tangelder GJ, Donker AJ, Stehouwer CD. Impaired skin capillary recruitment in essential hypertension is caused by both functional and structural capillary rarefaction. Hypertension. 2001;38:238-242.
    • (2001) Hypertension , vol.38 , pp. 238-242
    • Serné, E.H.1    Gans, R.O.2    ter Maaten, J.C.3    Tangelder, G.J.4    Donker, A.J.5    Stehouwer, C.D.6
  • 6
    • 0034751134 scopus 로고    scopus 로고
    • Capillary recruitment is impaired in essential hypertension and relates to insulin's metabolic and vascular actions
    • Serné EH, Gans RO, ter Maaten JC, ter Wee PM, Donker AJ, Stehouwer CD. Capillary recruitment is impaired in essential hypertension and relates to insulin's metabolic and vascular actions. Cardiovasc Res. 2001;49:161-168.
    • (2001) Cardiovasc Res , vol.49 , pp. 161-168
    • Serné, E.H.1    Gans, R.O.2    ter Maaten, J.C.3    ter Wee, P.M.4    Donker, A.J.5    Stehouwer, C.D.6
  • 7
    • 2642572617 scopus 로고    scopus 로고
    • Impaired microvascular function in obesity: Implications for obesity-associated microangiopathy, hypertension, and insulin resistance
    • de Jongh RT, Serne EH, IJzerman RG, de Vries G, Stehouwer CD. Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance. Circulation. 2004;109:2529-2535.
    • (2004) Circulation , vol.109 , pp. 2529-2535
    • de Jongh, R.T.1    Serne, E.H.2    IJzerman, R.G.3    de Vries, G.4    Stehouwer, C.D.5
  • 9
    • 0034064943 scopus 로고    scopus 로고
    • Alterations in skeletal muscle morphology in glucose-tolerant elderly hypertensive men: Relationship to development of hypertension and heart rate
    • Hedman A, Reneland R, Lithell HO. Alterations in skeletal muscle morphology in glucose-tolerant elderly hypertensive men: relationship to development of hypertension and heart rate. J Hypertens. 2000;18: 559-565.
    • (2000) J Hypertens , vol.18 , pp. 559-565
    • Hedman, A.1    Reneland, R.2    Lithell, H.O.3
  • 14
    • 0344055121 scopus 로고
    • Relations among activity, blood flow, and vascular state in skeletal muscle
    • Wright DL, Sonnenschein RR. Relations among activity, blood flow, and vascular state in skeletal muscle. Am J Physiol. 1965;208:782-789.
    • (1965) Am J Physiol , vol.208 , pp. 782-789
    • Wright, D.L.1    Sonnenschein, R.R.2
  • 15
    • 0028246442 scopus 로고
    • Heterogeneity of red blood cell perfusion in capillary networks supplied by a single arteriole in resting skeletal muscle
    • Ellis CG, Wrigley SM, Groom AC. Heterogeneity of red blood cell perfusion in capillary networks supplied by a single arteriole in resting skeletal muscle. Circ Res. 1994;75:357-368.
    • (1994) Circ Res , vol.75 , pp. 357-368
    • Ellis, C.G.1    Wrigley, S.M.2    Groom, A.C.3
  • 16
    • 4544386330 scopus 로고    scopus 로고
    • Unraveling the cellular mechanism of insulin resistance in humans: New insights from magnetic resonance spectroscopy
    • Shulman GI. Unraveling the cellular mechanism of insulin resistance in humans: new insights from magnetic resonance spectroscopy. Physiology (Bethesda). 2004;19:183-190.
    • (2004) Physiology (Bethesda) , vol.19 , pp. 183-190
    • Shulman, G.I.1
  • 17
    • 0028085621 scopus 로고
    • Hemodynamic actions of insulin
    • Baron AD. Hemodynamic actions of insulin. Am J Physiol. 1994;267: E187-E202.
    • (1994) Am J Physiol , vol.267
    • Baron, A.D.1
  • 18
    • 0036316948 scopus 로고    scopus 로고
    • Direct evidence for insulin-induced capillary recruitment in skin of healthy subjects during physiological hyperinsulinemia
    • Serné EH, IJzerman RG, Gans RO, Nijveldt R, de Vries G, Evertz R, Donker AJ, Stehouwer CD. Direct evidence for insulin-induced capillary recruitment in skin of healthy subjects during physiological hyperinsulinemia. Diabetes. 2002;51:1515-1522.
    • (2002) Diabetes , vol.51 , pp. 1515-1522
    • Serné, E.H.1    IJzerman, R.G.2    Gans, R.O.3    Nijveldt, R.4    de Vries, G.5    Evertz, R.6    Donker, A.J.7    Stehouwer, C.D.8
  • 21
    • 7044239439 scopus 로고    scopus 로고
    • Physiological hyperinsulinemia in dogs augments access of macromolecules to insulin-sensitive tissues
    • Ellmerer M, Kim SP, Hamilton-Wessler M, Hucking K, Kirkman E, Bergman RN. Physiological hyperinsulinemia in dogs augments access of macromolecules to insulin-sensitive tissues. Diabetes. 2004;53: 2741-2747.
    • (2004) Diabetes , vol.53 , pp. 2741-2747
    • Ellmerer, M.1    Kim, S.P.2    Hamilton-Wessler, M.3    Hucking, K.4    Kirkman, E.5    Bergman, R.N.6
  • 23
    • 33745295339 scopus 로고    scopus 로고
    • Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle
    • Clerk LH, Vincent MA, Jahn LA, Liu Z, Lindner JR, Barrett EJ. Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle. Diabetes. 2006;55:1436-1442.
    • (2006) Diabetes , vol.55 , pp. 1436-1442
    • Clerk, L.H.1    Vincent, M.A.2    Jahn, L.A.3    Liu, Z.4    Lindner, J.R.5    Barrett, E.J.6
  • 24
    • 7044269441 scopus 로고    scopus 로고
    • Free fatty acid levels modulate microvascular function: Relevance for obesity-associated insulin resistance, hypertension, and microangiopathy
    • de Jongh RT, Serne EH, IJzerman RG, de Vries G, Stehouwer CD. Free fatty acid levels modulate microvascular function: relevance for obesity-associated insulin resistance, hypertension, and microangiopathy. Diabetes. 2004;53:2873-2882.
    • (2004) Diabetes , vol.53 , pp. 2873-2882
    • de Jongh, R.T.1    Serne, E.H.2    IJzerman, R.G.3    de Vries, G.4    Stehouwer, C.D.5
  • 26
    • 0034974481 scopus 로고    scopus 로고
    • Heterogeneity of laser Doppler flowmetry in perfused muscle indicative of nutritive and nonnutritive flow
    • Clark AD, Youd JM, Rattigan S, Barrett EJ, Clark MG. Heterogeneity of laser Doppler flowmetry in perfused muscle indicative of nutritive and nonnutritive flow. Am J Physiol Heart Circ Physiol. 2001;280:H1324-H1333.
    • (2001) Am J Physiol Heart Circ Physiol , vol.280
    • Clark, A.D.1    Youd, J.M.2    Rattigan, S.3    Barrett, E.J.4    Clark, M.G.5
  • 27
    • 0035099864 scopus 로고    scopus 로고
    • Insulin stimulates laser Doppler signal by rat muscle in vivo, consistent with nutritive flow recruitment
    • Clark AD, Barrett EJ, Rattigan S, Wallis MG, Clark MG. Insulin stimulates laser Doppler signal by rat muscle in vivo, consistent with nutritive flow recruitment. Clin Sci. 2001;100:283-290.
    • (2001) Clin Sci , vol.100 , pp. 283-290
    • Clark, A.D.1    Barrett, E.J.2    Rattigan, S.3    Wallis, M.G.4    Clark, M.G.5
  • 28
    • 3142677991 scopus 로고    scopus 로고
    • Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers
    • de Jongh RT, Clark AD, IJzerman RG, Serne EH, de Vries G, Stehouwer CD. Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers. Diabetologia. 2004;47:978-986.
    • (2004) Diabetologia , vol.47 , pp. 978-986
    • de Jongh, R.T.1    Clark, A.D.2    IJzerman, R.G.3    Serne, E.H.4    de Vries, G.5    Stehouwer, C.D.6
  • 29
    • 0036889823 scopus 로고    scopus 로고
    • Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles
    • Eringa EC, Stehouwer CD, Merlijn T, Westerhof N, Sipkema P. Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles. Cardiovasc Res. 2002;56:464-471.
    • (2002) Cardiovasc Res , vol.56 , pp. 464-471
    • Eringa, E.C.1    Stehouwer, C.D.2    Merlijn, T.3    Westerhof, N.4    Sipkema, P.5
  • 30
    • 33646178955 scopus 로고    scopus 로고
    • Reciprocal relationships between insulin resistance and endothelial dysfunction: Molecular and pathophysiological mechanisms
    • Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation. 2006;113:1888-1904.
    • (2006) Circulation , vol.113 , pp. 1888-1904
    • Kim, J.A.1    Montagnani, M.2    Koh, K.K.3    Quon, M.J.4
  • 33
    • 34250648597 scopus 로고    scopus 로고
    • Acute blockade by endothelin-1 of haemodynamic insulin action in rats
    • Ross RM, Kolka CM, Rattigan S, Clark MG. Acute blockade by endothelin-1 of haemodynamic insulin action in rats. Diabetologia. 2007;50:443-451.
    • (2007) Diabetologia , vol.50 , pp. 443-451
    • Ross, R.M.1    Kolka, C.M.2    Rattigan, S.3    Clark, M.G.4
  • 34
  • 35
    • 0029933363 scopus 로고    scopus 로고
    • Insulin increases forearm vascular resistance in obese, insulin-resistant hypertensives
    • Gudbjornsdottir S, Elam M, Sellgren J, Anderson EA. Insulin increases forearm vascular resistance in obese, insulin-resistant hypertensives. J Hypertens. 1996;14:91-97.
    • (1996) J Hypertens , vol.14 , pp. 91-97
    • Gudbjornsdottir, S.1    Elam, M.2    Sellgren, J.3    Anderson, E.A.4
  • 36
    • 0348049454 scopus 로고    scopus 로고
    • Enhanced vascular activity of endogenous endothelin-1 in obese hypertensive patients
    • Cardillo C, Campia U, Iantorno M, Panza JA. Enhanced vascular activity of endogenous endothelin-1 in obese hypertensive patients. Hypertension. 2004;43:36-40.
    • (2004) Hypertension , vol.43 , pp. 36-40
    • Cardillo, C.1    Campia, U.2    Iantorno, M.3    Panza, J.A.4
  • 37
    • 0035152499 scopus 로고    scopus 로고
    • Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: Protective effect of vitamin C
    • Perticone F, Ceravolo R, Candigliota M, Ventura G, Iacopino S, Sinopoli F, Mattioli PL. Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C. Diabetes. 2001;50:159-165.
    • (2001) Diabetes , vol.50 , pp. 159-165
    • Perticone, F.1    Ceravolo, R.2    Candigliota, M.3    Ventura, G.4    Iacopino, S.5    Sinopoli, F.6    Mattioli, P.L.7
  • 38
    • 0032832102 scopus 로고    scopus 로고
    • Insulin regulation of glucose transport and phosphorylation in skeletal muscle assessed by PET
    • Kelley DE, Williams KV, Price JC. Insulin regulation of glucose transport and phosphorylation in skeletal muscle assessed by PET. Am J Physiol. 1999;277:E361-E369.
    • (1999) Am J Physiol , vol.277
    • Kelley, D.E.1    Williams, K.V.2    Price, J.C.3
  • 39
    • 33644784745 scopus 로고    scopus 로고
    • TNF-alpha levels are associated with skin capillary recruitment in humans: A potential explanation for the relationship between TNF-alpha and insulin resistance
    • IJzerman RG, Voordouw JJ, van Weissenbruch MM, Yudkin JS, Serne EH, Delemarre-van de Waal HA, Stehouwer CD. TNF-alpha levels are associated with skin capillary recruitment in humans: a potential explanation for the relationship between TNF-alpha and insulin resistance. Clin Sci. 2006;110:361-368.
    • (2006) Clin Sci , vol.110 , pp. 361-368
    • IJzerman, R.G.1    Voordouw, J.J.2    van Weissenbruch, M.M.3    Yudkin, J.S.4    Serne, E.H.5    Delemarre-van de Waal, H.A.6    Stehouwer, C.D.7
  • 41
    • 33644857995 scopus 로고    scopus 로고
    • Physiological concentrations of insulin induce endothelin-dependent vasoconstriction of skeletal muscle resistance arteries in the presence of tumor necrosis factor-alpha dependence on c-Jun N-terminal kinase
    • Eringa EC, Stehouwer CD, Walburg K, Clark AD, Nieuw Amerongen GP, Westerhof N, Sipkema P. Physiological concentrations of insulin induce endothelin-dependent vasoconstriction of skeletal muscle resistance arteries in the presence of tumor necrosis factor-alpha dependence on c-Jun N-terminal kinase. Arterioscler Thromb Vasc Biol. 2006;26:274-280.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 274-280
    • Eringa, E.C.1    Stehouwer, C.D.2    Walburg, K.3    Clark, A.D.4    Nieuw Amerongen, G.P.5    Westerhof, N.6    Sipkema, P.7
  • 43
    • 19744362790 scopus 로고    scopus 로고
    • Vasocrine signalling from perivascular fat: A mechanism linking insulin resistance to vascular disease
    • Yudkin JS, Eringa E, Stehouwer CD. "Vasocrine" signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease. Lancet. 2005;365:1817-1820.
    • (2005) Lancet , vol.365 , pp. 1817-1820
    • Yudkin, J.S.1    Eringa, E.2    Stehouwer, C.D.3
  • 45
    • 0028913094 scopus 로고
    • Non-insulin-dependent diabetes mellitus and fasting glucose and insulin concentrations are associated with arterial stiffness indexes. The ARIC Study. Atherosclerosis Risk in Communities Study
    • Salomaa V, Riley W, Kark JD, Nardo C, Folsom AR. Non-insulin-dependent diabetes mellitus and fasting glucose and insulin concentrations are associated with arterial stiffness indexes. The ARIC Study. Atherosclerosis Risk in Communities Study. Circulation. 1995;91: 1432-1443.
    • (1995) Circulation , vol.91 , pp. 1432-1443
    • Salomaa, V.1    Riley, W.2    Kark, J.D.3    Nardo, C.4    Folsom, A.R.5
  • 46
    • 33751073655 scopus 로고    scopus 로고
    • Insulin resistance, arterial stiffness and wave reflection
    • Yki-Jarvinen H, Westerbacka J. Insulin resistance, arterial stiffness and wave reflection. Adv Cardiol. 2007;44:252-260.
    • (2007) Adv Cardiol , vol.44 , pp. 252-260
    • Yki-Jarvinen, H.1    Westerbacka, J.2
  • 49
  • 50
    • 0035180072 scopus 로고    scopus 로고
    • Resistance to acute insulin induced decreases in large artery stiffness accompanies the insulin resistance syndrome
    • Westerbacka J, Seppala-Lindroos A, Yki-Jarvinen H. Resistance to acute insulin induced decreases in large artery stiffness accompanies the insulin resistance syndrome. J Clin Endocrinol Metab. 2001;86:5262-5268.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5262-5268
    • Westerbacka, J.1    Seppala-Lindroos, A.2    Yki-Jarvinen, H.3
  • 51
    • 33644875186 scopus 로고    scopus 로고
    • Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: The Framingham Heart Study
    • Mitchell GF, Vita JA, Larson MG, Parise H, Keyes MJ, Warner E, Vasan RS, Levy D, Benjamin EJ. Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: the Framingham Heart Study. Circulation. 2005;112: 3722-3728.
    • (2005) Circulation , vol.112 , pp. 3722-3728
    • Mitchell, G.F.1    Vita, J.A.2    Larson, M.G.3    Parise, H.4    Keyes, M.J.5    Warner, E.6    Vasan, R.S.7    Levy, D.8    Benjamin, E.J.9
  • 52
    • 0026101343 scopus 로고
    • Effects of local reduction in pressure on distensibility and composition of cerebral arterioles
    • Baumbach GL, Siems JE, Heistad DD. Effects of local reduction in pressure on distensibility and composition of cerebral arterioles. Circ Res. 1991;68:338-351.
    • (1991) Circ Res , vol.68 , pp. 338-351
    • Baumbach, G.L.1    Siems, J.E.2    Heistad, D.D.3
  • 53
    • 0026409555 scopus 로고
    • Reducing pulse pressure in hypertension may normalize small artery structure
    • Christensen KL. Reducing pulse pressure in hypertension may normalize small artery structure. Hypertension. 1991;18:722-727.
    • (1991) Hypertension , vol.18 , pp. 722-727
    • Christensen, K.L.1
  • 55


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.