Physiological hyperinsulinemia in dogs augments access of macromolecules to insulin-sensitive tissues

Diabetes

Volumn 53, Issue 11, 2004, Pages 2741-2747

  Ellmerer, Martin ^a   Kim, Stella P ^a   Hamilton Wessler, Marianthe ^a   Hücking, Katrin ^a   Kirkman, Erlinda ^a   Bergman, Richard N ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; INULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DOG; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; HYPERINSULINEMIA; INSULIN SENSITIVITY; INTERSTITIAL FLUID; LEG MUSCLE; MALE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL;

ANIMALS; CARBON RADIOISOTOPES; DOGS; HYPERINSULINISM; INSULIN; INULIN; ISOTOPE LABELING; MALE; MODELS, BIOLOGICAL; MUSCLE, SKELETAL;

EID: 7044239439     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.11.2741     Document Type: Article

References (32)

1. Liang C, Doherty JU, Faillace R, Maekawa K, Arnold S, Gavras H, Hood WB Jr. Insulin infusion in conscious dogs: effects on systemic and coronary hemodynamics, regional blood flows, and plasma catecholamines. J Clin Invest 69:1321-1336, 1982
2. James DE, Burleigh KM, Storlien LH, Bennett SP, Kraegen EW: Heterogeneity of insulin action in muscle: influence of blood flow. Am J Physiol 251:E422-E430, 1986
3. Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL: Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest 87:2246-2252, 1991
4. Laakso M, Edelman SV, Brechtel G, Baron AD: Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man: a novel mechanism for insulin resistance. J Clin Invest 85:1844-1852, 1990
5. Baron AD: Hemodynamic actions of insulin. Am J Physiol 267:E187-E202, 1994
6. Clark MG, Wallis MG, Barrett EJ, Vincent MA, Richards SM, Clerk LH, Rattigan S: Blood flow and muscle metabolism: a focus on insulin action. Am J Physiol Endocrinol Metab 284:E241-E258, 2003
7. Clark MG, Colquhoun EQ, Rattigan S, Dora KA, Eldershaw TP, Hall JL, Ye J: Vascular and endocrine control of muscle metabolism. Am J Physiol 268:E797-E812, 1995
8. Coggins M, Lindner J, Rattigan S, Jahn L, Fasy E, Kaul S, Barrett E: Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment. Diabetes 50:2682-2690, 2001
9. Vincent MA, Dawson D, Clark AD, Lindner JR, Rattigan S, Clark MG, Barrett EJ: Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow. Diabetes 51:42-48, 2002
10. Bonadonna RC, Saccomani MP, Del Prato S, Bonora E, DeFronzo RA, Cobelli C: Role of tissue-specific blood flow and tissue recruitment in insulin-mediated glucose uptake of human skeletal muscle. Circulation 98:234-241, 1998
11. Rasio EA, Mack E, Egdahl RH, Herrera MG: Passage of insulin and inulin across vascular membranes in the dog. Diabetes 17:668-672, 1968
12. Rasio EA, Hampers CL, Soeldner JS, Cahill GF Jr: Diffusion of glucose, insulin, inulin, and Evans blue protein into thoracic duct lymph of man. J Clin Invest 46:903-910, 1967
13. Yang YJ, Hope ID, Ader M, Bergman RN: Insulin transport across capillaries is rate limiting for insulin action in dogs. J Clin Invest 84:1620-1628, 1989
14. Jansson PA, Fowelin JP, von Schenck HP, Smith UP, Lonnroth PN: Measurement by microdialysis of the insulin concentration in subcutaneous interstitial fluid: importance of the endothelial barrier for insulin. Diabetes 42:1469-1473, 1993
15. Poulin RA, Steil GM, Moore DM, Ader M, Bergman RN: Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph. Diabetes 43:180-190, 1994
16. Rebrin K, Steil GM, Mittelman SD, Bergman RN: Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest 98:741-749, 1996
17. Finegood DT, Bergman RN, Vranic M: Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps: comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 36:914-924, 1987
18. Henthorn TK, Avram MJ, Frederiksen MC, Atkinson AJ Jr: Heterogeneity of interstitial fluid space demonstrated by simultaneous kinetic analysis of the distribution and elimination of inulin and gallamine. J Pharmacol Exp Ther 222:389-394, 1982
19. Steil GM, Meador MA, Bergman RN: Thoracic duct lymph: relative contribution from splanchnic and muscle tissue. Diabetes 42:720-731, 1993
20. Sedek GS, Ruo TI, Frederiksen MC, Frederiksen JW, Shih SR, Atkinson AJ Jr: Splanchnic tissues are a major part of the rapid distribution spaces of inulin, urea and theophylline. J Pharmacol Exp Ther 251:1026-1031, 1989
21. Milton SG, Knutson VP: Comparison of the function of the tight junctions of endothelial cells and epithelial cells in regulating the movement of electrolytes and macromolecules across the cell monolayer. J Cell Physiol 144:498-504, 1990
22. Whittingham JL, Havelund S, Jonassen I: Crystal structure of a prolonged-acting insulin with albumin-binding properties. Biochemistry 36:2826-2831, 1997
23. Stec GP, Atkinson AJ Jr: Analysis of the contributions of permeability and flow of intercompartmental clearance. J Pharmacokinet Biopharm 9:167-180, 1981
24. Steil GM, Richey J, Kim JK, Wi JK, Rebrin K, Bergman RN, Youn JH: Extracellular glucose distribution is not altered by insulin: analysis of plasma and interstitial L-glucose kinetics. Am J Physiol 271:E855-E864, 1996
25. Natali A, Buzzigoli G, Taddei S, Santoro D, Cerri M, Pedrinelli R, Ferrannini E: Effects of insulin on hemodynamics and metabolism in human forearm. Diabetes 39:490-500, 1990
26. Utriainen T, Malmstrom R, Makimattila S, Yki-Jarvinen H: Methodological aspects, dose-response characteristics and causes of interindividual variation in insulin stimulation of limb blood flow in normal subjects. Diabetologia 38:555-564, 1995
27. Hamilton-Wessler M, Ader M, Dea M, Moore D, Jorgensen PN, Markussen J, Bergman RN: Mechanism of protracted metabolic effects of fatty acid acylated insulin, NN304, in dogs: retention of NN304 by albumin. Diabetologia 42:1254-1263, 1999
28. Steil GM, Ader M, Moore DM, Rebrin K, Bergman RN: Transendothelial insulin transport is not saturable in vivo: no evidence for a receptor-mediated process. J Clin Invest 97:1497-1503, 1996
29. Hamilton-Wessler M, Ader M, Dea MK, Moore D, Loftager M, Markussen J, Bergman RN: Mode of transcapillary transport of insulin and insulin analog NN304 in dog hindlimb: evidence for passive diffusion. Diabetes 51:574-582, 2002
30. Colantuoni A, Bertuglia S, Coppini G, Donato L: Superposition of arteriolar vasomotion waves and regulation of blood flow in skeletal muscle microcirculation. Adv Exp Med Biol 277:549-558, 1990
31. Bouskela E, Cyrino FZ, Wiernsperger N: Effects of insulin and the combination of insulin plus metformin (glucophage) on microvascular reactivity in control and diabetic hamsters. Angiology 48:503-514, 1997
32. Renaudin C, Michoud E, Rapin JR, Lagarde M, Wiernsperger N: Hyperglycaemia modifies the reaction of microvessels to insulin in rat skeletal muscle. Diabetologia 41:26-33, 1998