Hepcidin and iron metabolism;L'hepcidine et le métabolisme du fer

Revue de Medecine Interne

Volumn 28, Issue 7, 2007, Pages 510-512

  Delaby, C ^a,b   Deybach, J C ^a,b   Beaumont, C ^a,b  

^a CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^b HÔPITAL LOUIS MOURIER   (France)

Author keywords

Anemia of chronic disease (ACD); Hemochromatosis; Hepcidin; Iron

Indexed keywords

HEPCIDIN; IRON; ANTIMICROBIAL CATIONIC PEPTIDE;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; HEMOCHROMATOSIS; INTESTINE ABSORPTION; IRON ABSORPTION; IRON BALANCE; IRON DEFICIENCY; IRON METABOLISM; IRON OVERLOAD; MACROPHAGE; MAMMAL; MOUSE; NONHUMAN; SHORT SURVEY; ANIMAL; ARTICLE; BLOOD; HOMEOSTASIS; HUMAN; METABOLISM;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; HOMEOSTASIS; HUMANS; INTESTINAL ABSORPTION; IRON; MACROPHAGES; MAMMALS;

EID: 34250865025     PISSN: 02488663     EISSN: 17683122     Source Type: Journal    
DOI: 10.1016/j.revmed.2007.03.009     Document Type: Short Survey

References (15)

1. Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 (1997) 482-488
2. Shayeghi M., Latunde-Dada G.O., Oakhill J.S., Laftah A.H., Takeuchi K., Halliday N., et al. Identification of an intestinal heme transporter. Cell 122 (2005) 789-801
3. Donovan A., Brownlie A., Zhou Y., Shepard J., Pratt S.J., Moynihan J., et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403 (2000) 776-781
4. Abboud S., and Haile D.J. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J. Biol. Chem. 275 (2000) 19906-19912
5. McKie A.T., Marciani P., Rolfs A., Brennan K., Wehr K., Barrow D., et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol. Cell 5 (2000) 299-309
6. Vulpe C.D., Kuo Y.M., Murphy T.L., Cowley L., Askwith C., Libina N., et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat. Genet. 21 (1999) 195-199
7. Cherukuri S., Potla R., Sarkar J., Nurko S., Harris Z.L., and Fox P.L. Unexpected role of ceruloplasmin in intestinal iron absorption. Cell Metab 2 (2005) 309-319
8. Ponka P., Beaumont C., and Richardson D.R. Function and regulation of transferrin and ferritin. Semin. Hematol. 35 (1998) 35-54
9. Levy J.E., Jin O., Fujiwara Y., Kuo F., and Andrews N.C. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat. Genet. 21 (1999) 396-399
10. Otterbein L.E., Soares M.P., Yamashita K., and Bach F.H. Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol. 24 (2003) 449-455
11. Ganz T. Hepcidin-a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol 18 (2005) 171-182
12. Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306 (2004) 2090-2093
13. Delaby C., Pilard N., Goncalves A.S., Beaumont C., and Canonne-Hergaux F. Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin. Blood 106 (2005) 3979-3984
14. Pietrangelo A. Non-HFE hemochromatosis. Hepatology 39 (2004) 21-29
15. Nemeth E., Rivera S., Gabayan V., Keller C., Taudorf S., Pedersen B.K., et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J. Clin. Invest. 113 (2004) 1271-1276