Ikaros is regulated through multiple histone modifications and deoxyribonucleic acid methylation in the pituitary

Molecular Endocrinology

Volumn 21, Issue 5, 2007, Pages 1205-1215

  Zhu, Xuegong ^a,c   Asa, Sylvia L ^b,c   Ezzat, Shereen ^a,c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; IKAROS TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; EPIGENETICS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPHYSIS CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MODIFICATION; REGULATORY MECHANISM;

ANIMALS; BASE SEQUENCE; DNA; DNA METHYLATION; EXONS; FEMALE; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HUMANS; IKAROS TRANSCRIPTION FACTOR; MALE; MICE; MOLECULAR SEQUENCE DATA; PITUITARY GLAND; RNA, MESSENGER;

EID: 34250834910     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2007-0053     Document Type: Article

References (24)

1. Georgopoulos K 2002 Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat Rev Immunol 2:162-174
2. Gomez-del Arco P, Koipally J, Georgopoulos K 2005 Ikaros SUMOylation: switching out of repression. Mol Cell Biol 25:2688-2697
3. Ezzat S, Mader R, Yu S, Ning T, Poussier P, Asa SL 2005 Ikaros integrates endocrine and immune system development. J Clin Invest 115:1021-1029
4. Ezzat S, Mader R, Fischer S, Yu S, Ackerley C, Asa SL 2006 An essential role for the hematopoietic transcription factor Ikaros in hypothalamic- pituitary-mediated somatic growth. Proc Natl Acad Sci USA 103: 2214-2219
5. Nichogiannopoulou A, Trevisan M, Neben S, Friedrich C, Georgopoulos K 1999 Defects in hemopoietic stem cell activity in Ikaros mutant mice. J Exp Med 190: 1201-1214
6. Winandy S, Wu P, Georgopoulos K 1995 A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 83:289-299
7. Winandy S, Wu L, Wang JH, Georgopoulos K 1999 Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros. J Exp Med 190: 1039-1048
8. Avitahl N, Winandy S, Friedrich C, Jones B, Ge Y, Georgopoulos K 1999 Ikaros sets thresholds for T cell activation and regulates chromosome propagation. Immunity 10:333-343
9. Koipally J, Georgopoulos K 2000 Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. J Biol Chem 275:19594-19602
10. Ezzat S, Yu S, Asa SL 2005 The zinc finger Ikaros transcription factor regulates pituitary growth hormone and prolactin gene expression through distinct effects on chromatin accessibility. Mol Endocrinol 19: 1004-1011
11. Ezzat S, Yu S, Asa SL 2003 Ikaros isoforms in human pituitary tumors: distinct localization, histone acetylation, and activation of the 5′ fibroblast growth factor receptor-4 promoter. Am J Pathol 163:1177-1184
12. Kaufmann C, Yoshida T, Perotti EA, Landhuis E, Wu P, Georgopoulos K 2003 A complex network of regulatory elements in Ikaros and their activity during hemo-lymphopoiesis. EMBO J 22:2211-2223
13. Li E 2002 Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet 3:662-673
14. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, Bird A 1998 Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393:386-389
15. Jackson JP, Lindroth AM, Cao X, Jacobsen SE 2002 Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature 416: 556-560
16. Espada J, Ballestar E, Fraga MF, Villar-Garea A, Juarranz A, Stockert JC, Robertson KD, Fuks F, Esteller M 2004 Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern. J Biol Chem 279:37175-37184
17. Koipally J, Renold A, Kim J, Georgopoulos K 1999 Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J 18:3090-3100
18. Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, Winandy S, Viel A, Sawyer A, Ikeda T, Kingston R, Georgopoulos K 1999 Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity 10:345-355
19. Ezzat S, Zhu X, Loeper S, Fischer S, Asa SL 2006 Tumor-derived Ikaros 6 acetylates the Bcl-XL promoter to upregulate a survival signal in pituitary cells. Mol Endocrinol 20:2976-2986
20. Yagi T, Hibi S, Takanashi M, Kano G, Tabata Y, Imamura T, Inaba T, Morimoto A, Todo S, Imashuku S 2002 High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis. Blood 99:1350-1355
21. Koipally J, Georgopoulos K 2002 Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression. J Biol Chem 277:23143-23149
22. Alexander JM 2001 Tumor suppressor loss in pituitary tumors. Brain Pathol 11:342-355
23. Asa SL, Ezzat S 2002 The pathogenesis of pituitary tumours. Nat Rev Cancer 2:836-849
24. Sun L, Liu A, Georgopoulos K 1996 Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J 15:5358-5369