Porcine liver-expressed antimicrobial peptides, hepcidin and LEAP-2: Cloning and induction by bacterial infection

Developmental and Comparative Immunology

Volumn 30, Issue 4, 2006, Pages 357-366

  Sang, Yongming ^a   Ramanathan, Balaji ^a   Minton, J Ernest ^a   Ross, Chris R ^a   Blecha, Frank ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

Antimicrobial peptide; Hepcidin, LEAP; Innate immunity; Sus scrofa

Indexed keywords

AMINO ACID; COMPLEMENTARY DNA; HEPCIDIN; LIVER EXPRESSED ANTIMICROBIAL PEPTIDE 2; MESSENGER RNA; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; BONE MARROW; CONTROLLED STUDY; DNA SEQUENCE; INTESTINE; KIDNEY; LIVER; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALMONELLA ENTERICA; SALMONELLA TYPHIMURIUM; SEROTYPE;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA; SALMONELLA; SALMONELLA ENTERICA; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; SALMONELLA TYPHIMURIUM; SUIDAE; SUS SCROFA;

EID: 29344453142     PISSN: 0145305X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dci.2005.06.004     Document Type: Article

References (30)

1. H.G. Boman Antibacterial peptides: basic facts and emerging concepts J Int Med 254 2003 197 215
2. T. Ganz Antimicrobial polypeptides J Leukoc Biol 75 2004 34 38
3. D. Yang, O. Chertov, S.N. Bykovskaia, Q. Chen, M.J. Buffo, and J. Shogan Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6 Science 286 1999 525 528
4. D. Yang, O. Chertov, and J.J. Oppenheim Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37) J Leukoc Biol 69 2001 691 697
5. D. Yang, A. Biragyn, L.W. Kwak, and J.J. Oppenheim Mammalian defensins in immunity: more than just microbicidal Trends Immunol 23 2002 291 296
6. B. Ramanathan, E.G. Davis, C.R. Ross, and F. Blecha Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity Microbes Infect 4 2002 361 372
7. Ramanathan B, Blecha F. Cathelicidins: antimicrobial peptides with nonmicrobicidal activities. In: Veskler BA, editor. Progress in Immunology Research. Nova Science Publishers. 2005. in press.
8. R.I. Lehrer, and T. Ganz Antimicrobial peptides in mammalian and insect host defense Curr Opin Immunol 11 1999 23 27
9. Y. Engstrom Induction and regulation of antimicrobial peptides in Drosophila Dev Comp Immunol 23 1999 345 358
10. C. Hetru, L. Troxler, and J.A. Hoffmann Drosophila melanogaster antimicrobial defense J Infect Dis 2 Suppl 2 2003 S327 S334
11. C.H. Park, E.V. Valore, A.J. Waring, and T. Ganz Hepcidin, a urinary antimicrobial peptide synthesized in the liver J Biol Chem 276 2001 7806 7810
12. A. Krause, S. Neitz, H.J. Magert, A. Schulz, W.G. Forssmann, and P. Schulz-Knappe LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity FEBS Lett 480 2000 147 150
13. T. Ganz Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation Blood 102 2003 783 788
14. C. Pigeon, G. Ilyin, B. Courselaud, P. Leroyer, B. Turlin, and P. Brissot A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload J Biol Chem 276 2001 7811 7819
15. M.M. Fry, J.L. Liggett, and S.J. Baek Molecular cloning and expression of canine hepcidin Vet Clin Pathol 33 2004 223 227
16. H. Shike, X. Lauth, M.E. Westerman, V.E. Ostland, J.M. Carlberg, and J.C. Van Olst Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge Eur J Biochem 269 2002 2232 2237
17. S.E. Douglas, J.W. Gallant, R.S. Liebscher, A. Dacanay, and S.C. Tsoi Identification and expression analysis of hepcidin-like antimicrobial peptides in bony fish Dev Comp Immunol 27 2003 589 601
18. H. Shike, C. Smimizu, X. Lauth, and J.C. Burns Organization and expression of the zebrafish hepcidin gene, an antimicrobial peptide gene conserved among vertebrates Dev Comp Immunol 28 2004 747 754
19. A. Krause, R. Sillard, B. Kleemeier, E. Kluver, E. Maronde, and J.R. Conejo-Garcia Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver Protein Sci 12 2003 143 152
20. D.J. Lynn, A.T. Lloyd, and C. O'Farrelly In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs) Vet Immunol Immunopathol 93 2003 177 184
21. G. Nicolas, M. Bennoun, I. Devaux, C. Beaumont, B. Grandchamp, and A. Kahn Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice Proc Natl Acad Sci USA 98 2001 8780 8785
22. H.N. Hunter, D.B. Fulton, T. Ganz, and H.J. Vogel The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis J Biol Chem 277 2002 37597 37603
23. G. Nicolas, L. Viatte, D.Q. Lou, M. Bennoun, C. Beaumont, and A. Kahn Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis Nat Genet 34 2003 97 101
24. E. Nemeth, M.S. Tuttle, J. Powelson, M.B. Vaughn, A. Donovan, and D.M. Ward Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Science 306 2004 2051 2053
25. T. Ganz Hepcidin in iron metabolism Curr Opin Hematol 11 2004 251 254
26. G. Papanikolaou, M. Tzilianos, J.I. Christakis, D. Bogdanos, K. Tsimirika, and J. Macfarlane Hepcidin in iron overload disorders Blood 105 2005 4103 4105
27. H. Wu, G. Zhang, J.E. Minton, C.R. Ross, and F. Blecha Regulation of cathelicidin gene expression: induction by lipopolysaccharide, interleukin-6, retinoic acid, and Salmonella enterica serovar Typhimurium infection Infect Immunol 68 2000 5552 5558
28. J.A. Whelan, N.B. Russell, and M.A. Whelan A method for the absolute quantification of cDNA using real-time PCR J Immunol Methods 278 2003 261 269
29. K. Nakayama Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins Biochem J 327 1997 625 635
30. T.A. Hall BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT Nucl Acids Symp Ser 41 1999 95 98