Toxicity of pyrimidine derivatives under oxidative stress conditions: Chemiluminescence-based assays in systems containing erythrocytes, mitochondria or blood plasma

Pharmacological Reports

Volumn 59, Issue 2, 2007, Pages 206-215

  Sajewicz, Waldemar ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Blood plasma; Chemiluminescence; Erythrocytes; Mitochondria; Oxidative stress; Thiopyrimidine toxicity

Indexed keywords

2,2' AZOBIS(2 AMIDINOPROPANE); FREE RADICAL; LUMINOL; OXYHEMOGLOBIN; PYRIMIDINE DERIVATIVE; TERT BUTYL HYDROPEROXIDE; THIOL DERIVATIVE; XENOBIOTIC AGENT;

ADULT; ARTICLE; CELL ASSAY; CELL ORGANELLE; CHEMICAL INTERACTION; CHEMOLUMINESCENCE; CONTROLLED STUDY; DRUG RESEARCH; DRUG STRUCTURE; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; EXPERIMENTAL MODEL; HEMOLYSATE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGHT; MITOCHONDRION; OXIDATIVE STRESS; PLASMA; TOXICOLOGY;

EID: 34250766698     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Alho H, Leinonen J: Total antioxidant activity measured by chemiluminescence methods. In: Methods in Enzymology. Ed. Packer L, Academic Press. San, Diego, London, Boston, New York, Tokyo, Toronto, 1999, 299 (Part A.). 3-15.
2. Allen RC: Phagocytic leukocyte oxygenation activities and chemiluminescence: a kinetic approach to analysis. In: Methods in Enzymology. Ed. De Luca MA, Mc Elroy WD, Academic Press, Orlando, San Diego, Austin, Boston. London, Sydney. Tokyo, Toronto, 1996. 133, 449-493.
3. Asmus KD: Sulfur-centered free radicals. In: Methods in Enzymology, Ed. Packer L, Glazer AN, Academic Press, San Diego, New York, Boston, London. Sydney, Tokyo, Toronto, 1990, 186 (Part B), 168-180.
4. Balazs C, Kiss E, Farid NR: The immunosuppressive effect of methimazole on cell-mediated immunity is mediated by its capacity to inhibit peroxidase and seavenge free oxygen radicals. Clin Endocrinol (Oxf), 1986, 25, 7-16.
5. Cronin MTD: Computer-aided prediction of drug toxicity in high-throughput screening. Pharm Pharmacol Commun, 1998, 4, 157-163.
6. Cronin MTD: Prediction of drug toxicity. Farmaco, 2001, 56, 149-151.
7. De Flora S, Izzotti A. D'Agostini F, Balansky RM: Mechanisms of N-acetyleysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis, 2001, 22, 999-1013.
8. Długosz A: The reaction of 4-mercaptopyrimidines with 2-(2'-aminoethylamino) ethanol. Pharmazie, 1902. 47, 186-188.
9. Długosz A: Synthesis and biological activity of pyrimidobenzodiazepine derivatives. New ring systems: triazolo- and tetrazolo-pyrimidobenzodiazepines. Pharmazie, 1995, 50, 180-182.
10. Dłgosz A, Machon Z: Syntheses of potentially active 1-substituted imidazo-[1, 2-c] pyrimidine derivatives Arch Pharm (Weinheim), 1986, 319, 102-108.
11. Evans SM, Casartelli A, Herreros E, Minnick DT, Day C, George E, Westmoreland C: Development of a high throughput in vitro toxicity screen predictive of a high acute in vivo toxic potential. Toxicol in Vitro. 2001, 15, 579-584.
12. Gustavson KE, Read HW, Harkin JM: Comprisons of human-cell-based and submitochondrial particle bioassay responses to the MEIC compounds in reference to human toxicity data. Toxicology, 2002, 177, 131-142.
13. Hix S, Kadüska MB, Mason RP, Augusto P: In vivo metabolism of tert-butyl hydroperoxide to methyl radicals. EPR spin-trapping and DNA methylation studies. Chem Res Toxicol, 2000, 13, 1056-1064.
14. Jain KS. Chitre TS, Miniyar PB, Kathiravan MK, Bendre VS, Veer VS, Shabane SR, Shishoo CJ: Biological and medicinal significance of pyrimidines. Curr Sci, 2006, 90, 793-803.
15. Johnston PA, Johnston PA: Cellular platforms for HTS: tree case studies. Drug Discov Today, 2002, 7, 353-363.
16. Kligore KS, Homeister JW, Satoh PS, Lucchesi BR: Sulfhydryl compounds, captopril, and MPG inhibit complement-mediated myocardial injury. Am J Physiol, 1994, 266, H28-H35.
17. Klimek J. Woźniak M, Szymariska G. Zelewski I.: Inhibitory effect of free radicals derived from organic hydroperoxide on progesterone synthesis in human term placental mitochondria. Free Radic Biol Med, 1999, 24, 1168-1175.
18. Kopff M, Kowalczyk E, Kopff A: Influence of selected cardiological drugs on oxidative status. Pol J Pharmaeol, 2004, 56, 265-269.
19. Kundu SC, Willson RI: Thiyl (sulfhydryl/thiol) free radical reactions, vitamins, β-carotene, and superoxide dismutase in oxidative stress: desígn and interpretation of enzymatic studies. In: Methods in Enzymology. Ed. Packer L, Academic Press, San Diego, New York Boston, London, Sydney, Tokyo, Toronto, 1995, 251 (Part A), 69-86.
20. Kuross AS, Rank BH, Hebbel RP: Excess beme in sickle erythrocyte inside-out membranes: possible role in thiol oxidation. Blood, 1988, 71, 876-882.
21. Li AP: Screening for human ADME/Tox drug properties in drug discovery. Drug, Discov Today, 2001, 6, 357-366.
22. Lichszteld K, Kruk I, Aboul-Enein Y, Guskos N, Kubera-Nowakowska L: Enhacing effect of carazolol on chemiluminescence accompanying decomposition of hydrogen peroxide in the presence of cooper ions. Pharmazie, 1999, 54, 898-902.
23. Machon Z, Długos A: Synthesis of some 2-hydroxy-4-mercapto-6-methylpyrimidine-5-carboxylic acid derivatives. Pol J Pharmacol Phann, 1973, 25, 579-585.
24. Mashiach E, Sela S, Weinstein T, Cohen HI, Shasha SM, Kristal B: Mesna: a novel protective antioxidant in ischaemic renal failure. Nephrol Dial Transplant, 2001, 16, 542-551.
25. Mason RP, Rao DNR: Thiyl free radical metabolites of thiol drugs, glutathione, and proteins. In: Method in Enzymology. Ed. Packer L, Glazer AN, Academic Press, San Diego, New York, Boston, London, Sydney, Tokyo, Toronto, 1990. 186 (Part B), 318-329.
26. Mates JM, Perez-Gomez C, Nunez de Castro I: Antioxidant enzymes and human diseases. Clin Biochem, 1999, 32, 595-603.
27. Munday R: In vivo toxicity of thiols: relationship to rate of one-electron oxidation by oxyhemoglobin. In: Methods in Enzymology. Ed. Packer L, Academic Press, San Diego, New York, Boston, London, Sydney, Tokyo, Toronto, 1995, 251 (Part A), 117-120.
28. Nohl H, Stolze K: The effecs of xenobiotics on erythrocytes. Gen Pharmacol, 1998, 31, 343-347.
29. Pallardy M, Kerdine S, Lebrec H: Testing strategeis in immunotoxicology. Toxicol Lett, 1998, 102-103, 257-260.
30. Pedersen PL, Greenawalt JW, Reynafarje B, Hullihen J, Decker GL, Soper JW, Bustamante E: Preparation and characterization of mitochondria and sub-mitochondrial particles of rat liver and liver-derivied tissues. Meth Cell Biol, 1979, 20, 411-481.
31. Radi R, Sims S, Cassina A, Turrens JF: Roles of catalase and cytochrome c in hydroperoxide-dependent lipid peroxidation and chemiluminescence in rat heart and kidney mitochondria. Free Radic Biol Med, 1993, 15, 653-659.
32. Slater K: Cytotoxicity tests for high-throughput drug discovery. Curr Opin Biotechnol, 2001, 12, 70-74.
33. Smith JA, Baker MS, Weidemann MJ: Free radical generation in hydroperoxide-treated erythrocytes monitored continuously by luminol-amplified chemiluminescence. Biochem Int, 1992, 28, 1009-1020.
34. Soneja A, Drews M, Malinski T: Role of nitric oxide. nitroxidative and oxidative stress in wound healing. Pharmacol Rep, 2005, 57, Suppl. 108-119.
35. Terstappen GC, Reggiani A. In silico research in drug discovery. Trends Pharmacol Sci, 2001, 22, 23-26.
36. Trotta RJ, Sullivan SG, Stern A: Lipid peroxidation and hermolobin degradation in red blood cells exposed to t-butyl hydroperoxide. Biochem J, 1983, 212, 759-771.
37. Young IS, Woodside JV: Antioxidants in health and disease. J Clin Pathol, 2001, 54, 176-186.