Comparisons of human-cell-based and submitochondrial particle bioassay responses to the MEIC compounds in reference to human toxicity data

Toxicology

Volumn 177, Issue 2-3, 2002, Pages 131-142

  Gustavson, Karl E ^a   Read, Harry W ^b   Harkin, John M ^b  

^a Harvard Bioscience   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Human cell; In vitro; MEIC; Submitochondrial particle; Toxicity

Indexed keywords

2 PROPANOL; 2,4 DICHLOROPHENOXYACETIC ACID; ACETYLSALICYLIC ACID; ALCOHOL; AMITRIPTYLINE; ARSENIC TRIOXIDE; CHEMICAL COMPOUND; COPPER SULFATE; DEXTROPROPOXYPHENE; DIAZEPAM; ETHYLENE GLYCOL; FLUORIDE SODIUM; LINDANE; LITHIUM CHLORIDE; MALATHION; MERCURY CHLORIDE; METHANOL; NICOTINE; PARACETAMOL; PARAQUAT; PHENOBARBITAL; PHENOL; POTASSIUM CYANIDE; PROPRANOLOL; SODIUM CHLORIDE; THALLIUM SULFATE; THEOPHYLLINE; THIORIDAZINE; UNINDEXED DRUG; WARFARIN;

ACCURACY; ARTICLE; BIOASSAY; CELL ASSAY; CONTROLLED STUDY; CORRELATION COEFFICIENT; CYTOTOXICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERMETHOD COMPARISON; PREDICTION; PRIORITY JOURNAL; SUBMITOCHONDRIAL PARTICLE; TOXICITY;

ANIMALS; CATTLE; CELL LINE; CELL SURVIVAL; HUMANS; SUBMITOCHONDRIAL PARTICLES; TOXICOLOGY;

EID: 0037102704     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00133-6     Document Type: Article

References (23)

1. Submitochondrial particle response to linear alkylbenzene sulfonates, nonylphenol polyethoxylates and their biodegradative derivatives
2. Submitochondrial particles as toxicity biosensors of chlorophenols
3. Comparison of in vitro submitochondrial particle and microtox assays for determining the toxicity of organotin compounds
4. Quantitative structure-activity relationships for the toxicity of chlorophenols to mammalian submitochondrial particles
5. Assessment of chloroaniline toxicity by the submitochondrial particle assay
6. An in-vitro mitochondrial bioassay for predicting acute toxicity in fish
7. MEIC evaluation of acute systemic toxicity. Part I. Methodology of 68 in-vitro toxicity assays used to test the first 30 reference chemicals
8. MEIC evaluation of acute systemic toxicity. Part II. In vitro results from 68 toxicity assays used to test the first 30 reference chemicals and a comparative cytotoxicity analysis
9. MEIC evaluation of acute systemic toxicity. Part III. In vitro results from 16 additional methods used to test the first 30 reference chemicals and a comparative cytotoxicity analysis
10. MEIC evaluation of acute systemic toxicity. Part IV. In vitro results from toxicity assays used to test reference chemicals 31-50 and a comparative cytotoxicity analysis
11. MEIC evaluation of acute systemic toxicity. Part VII. Prediction of human toxicity by results from testing of the first 30 reference chemicals with 27 further in-vitro assays
12. MEIC evaluation of acute systemic toxicity. Part V. Rodent and human toxicity data for the 50 reference chemicals
13. MEIC evaluation of acute systemic toxicity. Part VI. The prediction of human toxicity by rodent LD50 values and results from 61 in-vitro methods
14. MEIC evaluation of acute systemic toxicity. Part VIII. Multivariate partial least squares evaluation, including the selection of a battery of cell line tests with a good prediction of human acute lethal peak blood concentrations for 50 chemicals
15. Groundwater toxicity assessment using bioassay, chemical, and TIE analyses
16. Comparison of toxicities and mechanisms of action of n-alkanols in the submitochondrial particles and the Vibrio fischeri bioluminescence (Microtox) bioassay
17. H) which is capable of fully coupled oxidative phosphorylation
18. Assessment of chemical toxicity using mammalian mitochondrial electron transport particles
19. Use of submitochondrial particles for prediction of chemical toxicity in man
20. Environmental applications with submitochondrial particles
21. Modeling and prediction by using WHIM descriptors in QSAR studies: Submitochondrial particles (SMP) as toxicity biosensors of chlorophenols