Genetic linkage and association analyses for trait mapping in Plasmodium falciparum

Nature Reviews Genetics

Volumn 8, Issue 7, 2007, Pages 497-506

  Su, Xinzhuan ^a   Hayton, Karen ^a   Wellems, Thomas E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE;

ANTIGENIC VARIATION; CELL MATURATION; CELL POPULATION; CHROMOSOME; DISEASE TRANSMISSION; DRUG RESPONSE; EVOLUTION; GENE SEQUENCE; GENETIC LINKAGE; GENETIC TRAIT; GENOME; HAPLOTYPE; MALARIA; MOSQUITO; NONHUMAN; PHENOTYPE; PLASMODIUM; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; VIRULENCE;

ANIMALS; CHROMOSOME MAPPING; CROSSES, GENETIC; EVOLUTION; GENES, PROTOZOAN; GENOME, PROTOZOAN; HUMANS; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; MALARIA, FALCIPARUM; MICROSATELLITE REPEATS; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM; PLASMODIUM PARASITES;

EID: 34250744253     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg2126     Document Type: Review

References (21)

1. Levine, N. D. Progress in taxonomy of the Apicomplexan protozoa. J. Protozool. 35, 518-520 (1988).
2. Bruce-Chwatt, L. J. Essential Malariology (Oxford Univ. Press, New York, 1993).
3. Singh, B. et al. A large focus of naturally acquired Plasmodium knowlesi infections in human beings. Lancet 363, 1017-1024 (2004).
4. World Health Organization. The World Health Report 2005: Make Every Mother and Child Count. World Health Organization, Geneva. [online], 〈http://www.who.int/whr/2005〉 (2005).
5. Trager, W. & Jensen, J. B. Human malaria parasites in continuous culture. Science 193, 673-675 (1976). A landmark paper describing the methods for in vitro culture of P. falciparum.
6. Vanderberg, J. P. & Gwadz, R. W. in Malaria, Volume 2: Pathology, Vector Studies and Culture. (ed. Kreier, J. P.) 153-234 (Academic, New York, 1980).
7. Walliker, D. et al. Genetic analysis of the human malaria parasite Plasmodium falciparum. Science 236, 1661-1666 (1987). Description of the first genetic cross in P. falciparum.
8. Peterson, D. S., Walliker, D. & Wellems, T. E. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc. Natl Acad. Sci. USA 85, 9114-9118 (1988).
9. Wellems, T. E. et al. Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross. Nature 345, 253-255 (1990).
10. Wellems, T. E., Walker-Jonah, A. & Panton, L. J. Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7. Proc. Natl Acad. Sci. USA 88, 3382-3386 (1991).
11. Vaidya, A. B. et al. A genetic locus on Plasmodium falciparum chromosome 12 linked to a defect in mosquito infectivity and male gametogenesis. Mol. Biochem. Parasitol. 69, 65-71 (1995).
12. Su, X.-Z., Kirkman, L. A., Fujioka, H. & Wellems, T. E. Complex polymorphisms in an ∼330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa. Cell 91, 593-603 (1997).
13. Wang, P., Read, M., Sims, P. F. G. & Hyde, J. E. Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in the dihydropteroate synthase and an additional factor associated with folate utilization. Mol. Microbiol. 23, 979-986 (1997).
14. Su, X.-Z. et al. A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum. Science 286, 1351-1353 (1999). Description of the first high-resolution genetic map for P. falciparum.
15. Fidock, D. A. et al. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol. Cell 6, 861-871 (2000). The original description of the determinant of CQ resistance in P. falciparum.
16. Ferdig, M. T. et al. Dissecting the loci of low-level quinine resistance in malaria parasites. Mol. Microbiol. 52, 985-997 (2004).
17. Wang, P., Nirmalan, N., Wang, Q., Sims, P. F. & Hyde, J. E. Genetic and metabolic analysis of folate salvage in the human malaria parasite Plasmodium falciparum. Mol. Biochem. Parasitol. 135, 77-87 (2004).
18. Furuya, T. et al. Disruption of a Plasmodium falciparum gene linked to male sexual development causes early arrest in gametocytogenesis. Proc. Natl Acad. Sci. USA 102, 16813-16818 (2005).
19. Hoffman, S. L., Subramanian, G. M., Collins, F. H. & Venter, J. C. Plasmodium, human and Anopheles genomics and malaria. Nature 415, 702-709 (2002).
20. Crabb, B. S. Transfection technology and the study of drug resistance in the malaria parasite Plasmodium falciparum. Drug Resist. Updat. 5, 126-130 (2002).
21. Bozdech, Z. et al. The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol. 1, e5 (2003).