Synthesis and anti-proliterative in-vitro activity of two natural dihydrostilbenes and their analogues

Archiv der Pharmazie

Volumn 340, Issue 5, 2007, Pages 244-250

  Zhang, Wei Ge ^a,b   Zhao, Rui ^a   Ren, Jian ^a   Ren, Li Xiang ^a   Lin, Jin Guang ^a   Liu, Dai Lin ^b   Wu, Ying Liang ^a   Yao, Xin Sheng ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Key lab for Research and Development of New Drugs   (China)

Author keywords

Anti proliferative activity; Natural dihydrostilbene; Total synthesis

Indexed keywords

3 (2 (7 METHOXYBENZO[D][1,3]DIOXOL 5 YL)ETHYL)PHENOL; 6 (3 HYDROXYPHENETHYL)BENZO[D][1,3]DIOXOL 4 OL; DIHYDROSTILBENE DERIVATIVE; HYDROXYBENZOIC ACID; NATURAL PRODUCT; STILBENE DERIVATIVE; UNCLASSIFIED DRUG; 6 BROMO 3 (4 BUTYLPHENYL) 1,3 BENZOXAZINE 2,4 (3H) DIONE; 6-BROMO-3-(4-BUTYLPHENYL)-1,3-BENZOXAZINE-2,4-(3H)-DIONE; ANTINEOPLASTIC AGENT; BENZOXAZINE DERIVATIVE;

ARTICLE; BULBOPHYLLUM ODORATISSIMUM; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HORNER REACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PLANT; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TRADITIONAL MEDICINE; CHEMISTRY; COLORIMETRY; DRUG EFFECT; DRUG SCREENING; IC 50; ORCHIDACEAE; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZOXAZINES; CELL LINE, TUMOR; CELL PROLIFERATION; COLORIMETRY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; ORCHIDACEAE; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34250702657     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200600146     Document Type: Article

References (21)

1. L. Belguendouz, L. Fremont, A. Linard, Biochem. Pharmacol. 1997, 53, 1347-1355.
2. P. Waffo-Teguo, M. E. Hawthorne, M. Cuendet, J. M. Merillon, et al., Nutr. Cancer 2001, 40, 173-179.
3. G. R. Pettit, S. B. Singh, E. Hamel, Experientia 1989, 45, 209-211.
4. K. Likhitwitayawuid, K. Sawasdee, K. Kirtikara, Planta. Med. 2002, 68, 841-843.
5. C. R. Pace-Asciak, O. Rounova, S. E. Hahn, E. P. Diamandis, D. M. Goldberg, Clin. Chim. Acta. 1996, 246, 163-182.
6. F. Mu, E. Hamel, D. J. Lee, D. E. Pryor, M. Cushman, J. Med. Chem. 2003, 46, 1670-1682.
7. H. Kobayashi, M. Namikoshi, T. Yoshimoto, T. Yokochi, J. Antibiotics 1996, 49, 873-879.
8. State Administration of Traditional Chinese Medicine (1999), Zhang-Hua-Ben-Cao (Shanghai Science and Technology Press, Shanghai), Vol. 8, p.681.
9. X. S. Yao, N. L. Wang, S. Kitanaka, D. L. Liu, J. X. Zhang, Faming Zhuanli Gongkai Shuomingshu (Chinese Patent), CN 1594309A
10. T. L. Majumder, B. Mausumi, Phytochemistry 1991, 30, 321-324.
11. J. V. Bhaskar-Kanth, P. Mariappan, J. Org. Chem. 1991, 56, 5964-5965.
12. H. Firouzabadi, M. Fakoorpour, H. Hazarkhani, Syn. Commun. 2001, 31, 3859-3862.
13. A. S. Krauss, W. C. Taylor, Aust. J. Chem. 1991, 44, 1307-1333.
14. K. M. Khan, M. Rasheed, Z. Ullah, S. Hayat, et al., Bioorg. Med. Chem. 2003, 11, 1381-1387.
15. J. Lee, J. Lee, S. Y. Kim, N. A. Perry, et al., Bioorg. Med. Chem. 2006, 14, 2022-2031.
16. C. F. Lin, J. S. Yang, C. Y. Chang, Bioorg. Med. Chem. 2005, 13, 1537-1544.
17. A. Alam, Y. Takaguchi, H. Ito, T. Yoshida, S. Tsuboi, Tetrahedron 2005, 61, 1909-1918.
18. G. R. Pettit, S. B. Singh, Can. J. Chem. 1987, 65, 2390-2396.
19. S. Jinno, T. Okita, Heterocycles 1999, 51, 303-314.
20. G. Y. Moltrasio, D. Giacopello, M. J. Vernengo, Org. Prep. Proced. Int. 1972, 4, 13-18.
21. T. Mosmann, J. Immunol. Methods 1983, 65, 55-63.