A screening method for antimitotic and antifungal substances using conidia of Pyricularia oryzae, modification and application to tropical marine fungi

Journal of Antibiotics

Volumn 49, Issue 9, 1996, Pages 873-879

  Kobayashi, Hisayoshi ^a   Namikoshi, Michio ^b   Yoshimoto, Takeshi ^b   Yokochi, Toshihiro ^c  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO UNIVERSITY OF MARINE SCIENCE AND TECHNOLOGY   (Japan)

^c NATL INST BIOSCI HUM TECHNOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANSAMITOCIN P 3; ANTIFUNGAL AGENT; ANTIMITOTIC AGENT; CHAETOGLOBOSIN A; COLCHICINE; CYCLOHEXIMIDE; CYTOCHALASIN; ECONAZOLE; FLUCYTOSINE; GRISEOFULVIN; KASUGAMYCIN; NOCODAZOLE; PACLITAXEL; RHIZOXIN; TIABENDAZOLE; UNCLASSIFIED DRUG; VINBLASTINE SULFATE; VINCRISTINE SULFATE;

ANTIFUNGAL ACTIVITY; ARTICLE; BIOASSAY; CELL SHAPE; CELL STRUCTURE; CHAETOMIUM; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; FUNGUS; MINIMUM INHIBITORY CONCENTRATION; MYCELIUM; NONHUMAN; PRIORITY JOURNAL;

EID: 0029923988     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.49.873     Document Type: Article

References (15)

1. RICHMOND, D. V.: Effects of toxicants on the morphology and fine structure of fungi. Adv. Appl. Microbiol. 19: 289-319, 1975
2. BRIAN, P. W.: Studies on the biological activity of griseofulvin. Ann. Bot. 13: 59-77, 1949
3. BETINA, V. & D. MICEKOVA: Morphogenetic activity of cytochalasins, cyanein, and monorden in Botrytis cinerea. Z. Allg. Mikrobiol. 13: 287-298, 1973
4. ISONO, K.; K. KOBINATA & S. SUZUKI: Isolation and characterization of polyoxins J, K and L, New components of polyoxin complex. Agric. Biol. Chem. 32: 792-793, 1968
5. BEPPU, T.: Morphological abnormalities of eukaryotic cells induced by microbial metabolites as indices to direct nobel physiological activities. Protein, Nucleic Acid and Enzyme 38: 1639-1646, 1993
6. GUNJI, S.; K. ARIMA & T. BEPPU: Screening of antifungal antibiotics according to activities inducing morphological abnormalities. Agric. Biol. Chem. 47: 2061-2069, 1983
7. MARUMO, S.; M. NUKINA, S. KONDO & K. TOMIYAMA: Lunatoic acid A a morphogenic substance inducing chlamydospore-like cells in some fungi. Agric. Biol. Chem. 46: 2399-2401, 1982
8. SAKAMOTO, K.; S. IZUMI, M. MIYACHI & M. OKUHARA: A new assay method for immunosuppressants with a tacrolims (FK 506)-like mode of action. J. Antibiotics 48: 727-729, 1995
9. TAKAHASHI, M.; S. IWASAKI, H. KOBAYASHI, S. OKUDA, T. MURAI, Y. SATO, T. HARAGUCHI-HIRAOKA & H. NAGANO: Studies on macrocyclic lactone antibiotics XI. Antimitotic and anti-tubulin activity of new antitumor antibiotics, rhizoxins and its homologues. J. Antibiotics 40: 66-72, 1987
10. KOBAYASHI, H.; R. SUNAGA, K. FURIHATA, N. MORISAKI & S. IWASAKI: Isolation and structures of an antifungal antibiotic, fusarielin A, and related compounds produced by a Fusarium sp. J. Antibiotics 48: 42-52, 1995
11. SEKITA, S.; K. YOSHIHIRA, S. NATORI & H. KUWANO: Structures of chaetoglobosins A and B, cytotoxic metabolites of Chaetomium globosum. Tetrahedron Lett. 1973: 2109-2112, 1973
12. SHELANSKI, M.; F. GASKIN & C. R. CAUTER: Microtubule assembly in the absence of added nucleotides. Pro. Natl. Acad. Sci. U.S.A. 70: 765-768, 1973
13. SATO, Y.; Y. SAITO, T. TEZUKA, S. SEKITA, K. YOSHIHARA & S. NATORI: Viscometric analysis of effects of cytochalasans on in vitro polymerization and depolymerization of microtubules. J. Phar. Dyn. 5: 418-422, 1982
14. UMEDA, M.; K. OHTSUBO, M. SAITO, S. SEKITA, K. YOSHIHIRA, S. NATORI, S. UDAGAWA, F. SAKABE & H. KURATA: Cytotoxicity of new cytochalasans from Chaetomium globosum. Experientia 31: 435-439, 1975
15. SEKITA, S.; K. YOSHIHIRA, S. NATORI, S. UDAGAWA, F. SAKABE, H. KURATA & M. UMEDA: Chaetoglobosins, cytotoxic 10-(indol-3-yl)-[13]cytochalasans from Chaetomium spp. Chem. Pharm. Bull. 30: 1609-1617, 1982