2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 6, 2006, Pages 2022-2031

  Lee, Jeewoo ^a   Lee, Ju Hyun ^a   Kim, Su Yeon ^a   Perry, Nicholas A ^b   Lewin, Nancy E ^b   Ayres, Jolene A ^b   Blumberg, Peter M ^b  

^a Seoul National University   (South Korea)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Diacylglycerol; Phorbol ester; Protein kinase C

Indexed keywords

2 (2 HYDROXYPHENYL) 3 HYDROXYPROPYLPIVALATE; 2 (3 HYDROXYPHENYL) 3 HYDROXYPROPYLPIVALATE; 2 [2 (BENZYLOXY)BENZYL] 3 HYDROXYPROPYLPIVALATE; 2 [2 (BENZYLOXY)PHENYL] 3 HYDROXYPROPYLPIVALATE; 2 [2 (HEXANOYLOXY)BENZYL] 3 HYDROXYPROPYLPIVALATE; 2 [2 (HEXANOYLOXY)PHENYL] 3 HYDROXYPROPYLPIVALATE; 2 [3 (BENZYLOXY)BENZYL] 3 HYDROXYPROPYLPIVALATE; 2 [3 (BENZYLOXY)PHENYL] 3 HYDROXYPROPYLPIVALATE; 2 [3 (HEXANOYLOXY)BENZYL] 3 HYDROXYPROPYLPIVALATE; 2 [3 (HEXANOYLOXY)PHENYL] 3 HYDROXYPROPYLPIVALATE; 2 [4 (BENZYLOXY)BENZYL] 3 HYDROXYPROPYLPIVALATE; 2 [4 (BENZYLOXY)PHENYL] 3 HYDROXYPROPYLPIVALATE; 2 [4 (HEXANOYLOXY)BENZYL] 3 HYDROXYPROPYLPIVALATE; 2 [4 (HEXANOYLOXY)PHENYL] 3 HYDROXYPROPYLPIVALATE; 2 BENZYL 3 HYRDOXYLPROPYLPIVALIC ACID; 2 PHENYL 3 HYDROXYPROPYLPIVALIC ACID; 3 HYDROXY 2 (2 HYDROXYBENZYL)PROPYLPIVALATE; 3 HYDROXY 2 (3 HYDROXYBENZYL)PROPYLPIVALATE; ACETIC ACID DERIVATIVE; DIOCTANOIN; GLYCEROL 2 ACETATE 1 OLEATE; PHORBOL ESTER DERIVATIVE; PROTEIN KINASE C ALPHA; TETRAHYDROFURAN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; MOLECULAR MODEL; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

BINDING SITES; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PENTANOIC ACIDS; PHORBOLS; PROTEIN KINASE C-ALPHA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 32044445721     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.10.051     Document Type: Article

References (21)

1. D.S. Lester R.M. Epand Protein Kinase C. Current Concepts and Future Perspectives 1992 Ellis Horwood New York
2. J.F. Kuo Protein Kinase C 1994 Oxford University Press New York
3. Y. Nishizuka Science 258 1992 607
4. A.C. Newton Chem. Rev. 101 2001 2353
5. C. Yang, and M.G. Kazanietz TIPS 24 2003 602
6. P.M. Blumberg Mol. Carcinog. 4 1991 339
7. M.G. Kazanietz, M.J. Caloca, P. Eroles, T. Fujii, M.L. Garcia-Bermejo, M. Reilly, and H.B. Wang Biochem. Pharmacol. 2000 60
8. V.E. Marquez, K. Nacro, S. Benzaria, J. Lee, R. Sharma, K. Teng, G.W.A. Milne, B. Bienfait, S. Wang, N.E. Lewin, and P.M. Blumberg Pharmacol. Ther. 82 1999 251
9. V.E. Marquez, and P.M. Blumberg Acc. Chem. Res. 36 2003 434
10. J.-H. Kang, M.A. Siddiqui, N.E. Lewin, Y. Pu, D.M. Sigano, P.M. Blumberg, J. Lee, and V.E. Marquez Org. Lett. 6 2004 2413
11. J. Lee, S. Wang, G.W.A. Milne, R. Sharma, N.E. Lewin, P.M. Blumberg, and V.E. Marquez J. Med. Chem. 39 1996 29
12. H. Nakamura, Y. Kishi, M.A. Pajares, and R.R. Rando Proc. Natl. Acad. Sci. U.S.A. 86 1989 9672
13. R.R. Rando, and Y. Kishi Biochemistry 31 1992 2211
14. S. Wang, G.W.A. Milne, M.C. Nicklaus, V.E. Marquez, J. Lee, and P.M. Blumberg J. Med. Chem. 4 1994 1326
15. J. Lee, J.-H. Kang, S.-Y. Lee, K.-C. Han, C.M. Torres, D.K. Bhattacharyya, P.M. Blumberg, and V.E. Marquez J. Med. Chem. 42 1999 4129
16. G. Krauter, C.W. Von der Lieth, R. Schmidt, and E. Hecker Eur. J. Biochem. 242 1996 417
17. K. Sugita, C.F. Neville, M. Sodeoka, H. Sasai, and M. Shibasaki Tetrahedron Lett. 36 1995 1067
18. M. Sodeoka, K. Uotsu, and M. Shibasaki Tetrahedron Lett. 36 1995 8795
19. M.G. Kazanietz, K.W. Krausz, and P.M. Blumberg J. Biol. Chem. 267 1992 20878
20. G. Zhang, M.G. Kazanietz, P.M. Blumberg, and J.H. Hurley Cell 81 1995 917
21. K. Nacro, D.M. Sigano, S. Yan, M.C. Nicklaus, L.L. Pearce, N.E. Lewin, S.H. Garfield, P.M. Blumberg, and V.E. Marquez J. Med. Chem. 44 2001 1892