Interferon-β modulates bone-associated cytokines and osteoclast precursor activity in multiple sclerosis patients

Multiple Sclerosis

Volumn 12, Issue 5, 2006, Pages 541-550

  Weinstock Guttman, Bianca ^a   Hong, Jianming ^b   Santos, Roseane ^b   Tamaño Blanco, Miriam ^b   Badgett, Darlene ^b   Patrick, Kara ^a   Baier, Monika ^c   Feichter, Joan ^a   Gallagher, Eileen ^a   Garg, Neeta ^a   Ramanathan, Murali ^a,b,d  

^a BUFFALO GENERAL HOSPITAL   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d Department of Pharmaceutical Sciences ^*  (United States)

Author keywords

Bone; Gene expression; Interferons; Multiple sclerosis; Osteoporosis; Pharmacodynamics

Indexed keywords

BETA1A INTERFERON; CARBOXY TERMINAL TELOPEPTIDE; CYTOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; BETA INTERFERON; BIOLOGICAL RESPONSE MODIFIER; COLLAGEN TYPE 1; COLLAGEN TYPE I TRIMERIC CROSS LINKED PEPTIDE; COLLAGEN TYPE I TRIMERIC CROSS-LINKED PEPTIDE; MESSENGER RNA; PEPTIDE; TNFSF10 PROTEIN, HUMAN;

ADULT; ARTICLE; BLOOD SAMPLING; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; FEMALE; GENE EXPRESSION; HOMEOSTASIS; HUMAN; MALE; MULTIPLE SCLEROSIS; OSTEOCLAST; PERIPHERAL LYMPHOCYTE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; BIOSYNTHESIS; BLOOD; COMPARATIVE STUDY; DRUG EFFECT; EVALUATION; METABOLISM; METHODOLOGY; MIDDLE AGED; NONPARAMETRIC TEST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME;

ADULT; BIOLOGICAL RESPONSE MODIFIERS; COLLAGEN TYPE I; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HUMANS; INTERFERON-BETA; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; OSTEOCALCIN; OSTEOPROTEGERIN; PEPTIDES; RANK LIGAND; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; TIME FACTORS; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 34250683459     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458506070605     Document Type: Article

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