Increased numbers of CCR5+ interferon-γ- and tumor necrosis factor-α- secreting T lymphocytes in multiple sclerosis patients

Annals of Neurology

Volumn 47, Issue 2, 2000, Pages 269-273

  Strunk, Tobias ^a   Bubel, Stefanie ^a   Mascher, Beate ^a   Schlenke, Peter ^a   Kirchner, Holger ^a   Wandinger, Klaus Peter ^b  

^a UNIVERSITY OF LÜBECK   (Germany)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CLINICAL ARTICLE; DISEASE CARRIER; FEMALE; HUMAN; LYMPHOCYTE COUNT; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ADULT; ANTIGENS, CD26; FEMALE; HUMANS; INTERFERON TYPE II; IONOMYCIN; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; RECEPTORS, CCR5; REFERENCE VALUES; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033960291     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(200002)47:2<269::AID-ANA23>3.0.CO;2-G     Document Type: Article

References (10)

1. Martin R, McFarland HF, McFarlin DE. Immunological aspects of demyelinating diseases. Annu Rev Imumnol 1992;10: 153-187
2. Beck J, Rondot P, Catinot L, et al. Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations? Acta Neurol Scand 1988;78:318-323
3. Sharief MK, Hentges R. Association between tumor necrosis factor-α and disease progression in patients with multiple sclerosis. N Engl J Med 1991;325:467-472
4. Ward SG, Bacon K, Westwick J. Chemokines and T lymphocytes: more than in attraction. Immunity 1998;9:1-11
5. Bonecchi R, Bianchi G, Bordignon PP, et al. Differential expression of chemokine receptors and chemotactic responsiveness of type-1 T-helper cells (Th1s) and Th2s. J Exp Med 1998; 187:129-134
6. Hafler DA, Chofflon M, Benjamin D, et al. Mechanisms of immune memory: T cell activation and CD3 phosphorylation correlates with Ta1 (CDw26) expression. J Immunol 1989;142: 2590-2596
7. Qin S, Rottman JB, Myers P, et al. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest 1998;101:746-754
8. Panitch HS, Hirsch RL, Schindler J, Johnson KP. Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system. Neurology 1987; 37:1097-1102
9. Sorensen TL, Tani M, Jensen J, et al. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest 1999;103:807-815
10. Balashov KE, Rottman JB, Weiner HL, Hancock WW. CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions. Proc Nad Acad Sci USA 1999;96: 6873-6878