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Baroni SS, Santillo M, Bevilacqua F, et al.: Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med 2006, 354:2667-2676. This is the first published report describing the presence in SSc patients of PDGFR-stimulating antibodies, which can increase synthetic activity of fibroblasts and promote their differentiation into myofibroblasts. This is of great interest, because PDGF function has been linked to aberrant tissue fibrogenesis as well as intimal hyperplasia in different obliterative vascular disorders. If confirmed in larger studies, these data may provide the rationale for treatment strategies targeted to direct pathogenetic mechanisms in SSc.
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