메뉴 건너뛰기




Volumn 20, Issue 7, 2007, Pages 779-787

Diffuse sclerosing variant of papillary thyroid carcinoma: Lack of BRAF mutation but occurrence of RET/PTC rearrangements

Author keywords

BRAF; Diffuse sclerosing variant of papillary thyroid carcinoma; RET PTC rearrangement

Indexed keywords

B RAF KINASE; DNA; PROTEIN RET;

EID: 34250614670     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.3800797     Document Type: Article
Times cited : (76)

References (59)
  • 2
    • 17744412728 scopus 로고    scopus 로고
    • Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in the united states during 1996. U.S. and German Thyroid Cancer Study Group. An American College of Surgeons Commission on Cancer Patient Care Evaluation study
    • Hundahl SA, Cady B, Cunningham MP, et al. Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in the united states during 1996. U.S. and German Thyroid Cancer Study Group. An American College of Surgeons Commission on Cancer Patient Care Evaluation study. Cancer 2000;89:202-217.
    • (2000) Cancer , vol.89 , pp. 202-217
    • Hundahl, S.A.1    Cady, B.2    Cunningham, M.P.3
  • 3
    • 33646684498 scopus 로고    scopus 로고
    • Papillary carcinoma of thyroid: A 30-yr clinicopathological review of the histological variants
    • Lam AK, Lo CY, Lam KS. Papillary carcinoma of thyroid: a 30-yr clinicopathological review of the histological variants. Endocr Pathol 2005;16:323-330.
    • (2005) Endocr Pathol , vol.16 , pp. 323-330
    • Lam, A.K.1    Lo, C.Y.2    Lam, K.S.3
  • 4
    • 0024829646 scopus 로고
    • Diffuse sclerosing variant of papillary thyroid carcinoma. Clinicopathologic study of 15 cases
    • Carcangiu ML, Bianchi S. Diffuse sclerosing variant of papillary thyroid carcinoma. Clinicopathologic study of 15 cases. Am J Surg Pathol 1989;13:1041-1049.
    • (1989) Am J Surg Pathol , vol.13 , pp. 1041-1049
    • Carcangiu, M.L.1    Bianchi, S.2
  • 5
    • 0025668493 scopus 로고
    • Diffuse sclerosing variant of papillary carcinoma of the thyroid. Clinical importance, surgical treatment, and follow-up study
    • Fujimoto Y, Obara T, Ito Y, et al. Diffuse sclerosing variant of papillary carcinoma of the thyroid. Clinical importance, surgical treatment, and follow-up study. Cancer 1990;66:2306-2312.
    • (1990) Cancer , vol.66 , pp. 2306-2312
    • Fujimoto, Y.1    Obara, T.2    Ito, Y.3
  • 6
    • 0034108635 scopus 로고    scopus 로고
    • Multiple brain metastases from a diffuse sclerosing variant of papillary carcinoma of the thyroid
    • Imamura Y, Kasahara Y, Fukuda M. Multiple brain metastases from a diffuse sclerosing variant of papillary carcinoma of the thyroid. Endocr Pathol 2000;11:97-108.
    • (2000) Endocr Pathol , vol.11 , pp. 97-108
    • Imamura, Y.1    Kasahara, Y.2    Fukuda, M.3
  • 8
    • 24644464655 scopus 로고    scopus 로고
    • Thyroid gland
    • Rosai J, Ackerman L eds, 9th edn. Mosby: Edinburgh, London, New York, Oxford, Philadelphia, St Louis, Sydney, Toronto
    • Rosai J. Thyroid gland. In: Rosai J, Ackerman L (eds). Rosai and Ackerman's Surgical Pathology, 9th edn. Mosby: Edinburgh, London, New York, Oxford, Philadelphia, St Louis, Sydney, Toronto, 2004, pp 515-594.
    • (2004) Rosai and Ackerman's Surgical Pathology , pp. 515-594
    • Rosai, J.1
  • 9
    • 1842830286 scopus 로고    scopus 로고
    • A review of thyroid cancer with intermediate differentiation
    • Sywak M, Pasieka JL, Ogilvie T. A review of thyroid cancer with intermediate differentiation. J Surg Oncol 2004;86:44-54.
    • (2004) J Surg Oncol , vol.86 , pp. 44-54
    • Sywak, M.1    Pasieka, J.L.2    Ogilvie, T.3
  • 10
    • 31544466290 scopus 로고    scopus 로고
    • Diffuse sclerosing variant of papillary carcinoma of the thyroid: A 35-year comparative study at a single institution
    • Lam AK, Lo CY. Diffuse sclerosing variant of papillary carcinoma of the thyroid: a 35-year comparative study at a single institution. Ann Surg Oncol 2006;13:176-181.
    • (2006) Ann Surg Oncol , vol.13 , pp. 176-181
    • Lam, A.K.1    CY, L.2
  • 11
    • 33646680746 scopus 로고    scopus 로고
    • Diffuse sclerosing variant of papillary thyroid carcinoma: A clinicopathologic and immunophenotypic analysis of 22 cases
    • Thompson LD, Wieneke JA, Heffess CS. Diffuse sclerosing variant of papillary thyroid carcinoma: a clinicopathologic and immunophenotypic analysis of 22 cases. Endocr Pathol 2005;16:331-348.
    • (2005) Endocr Pathol , vol.16 , pp. 331-348
    • Thompson, L.D.1    Wieneke, J.A.2    Heffess, C.S.3
  • 12
    • 0025093370 scopus 로고
    • Diffuse sclerosing variant of papillary thyroid carcinoma. S-100 protein immunocytochemistry and prognosis
    • Schroder S, Bay V, Dumke K, et al. Diffuse sclerosing variant of papillary thyroid carcinoma. S-100 protein immunocytochemistry and prognosis. Virchows Arch A Pathol Anat Histopathol 1990;416:367-371.
    • (1990) Virchows Arch A Pathol Anat Histopathol , vol.416 , pp. 367-371
    • Schroder, S.1    Bay, V.2    Dumke, K.3
  • 14
    • 0028821932 scopus 로고
    • Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident
    • Fugazzola L, Pilotti S, Pinchera A, et al. Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident. Cancer Res 1995;55:5617-5620.
    • (1995) Cancer Res , vol.55 , pp. 5617-5620
    • Fugazzola, L.1    Pilotti, S.2    Pinchera, A.3
  • 15
    • 6244280442 scopus 로고
    • High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident
    • Klugbauer S, Lengfelder E, Demidchik EP, et al. High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident. Oncogene 1995;11:2459-2467.
    • (1995) Oncogene , vol.11 , pp. 2459-2467
    • Klugbauer, S.1    Lengfelder, E.2    Demidchik, E.P.3
  • 16
    • 0030941779 scopus 로고    scopus 로고
    • Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children
    • Nikiforov YE, Rowland JM, Bove KE, et al. Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. Cancer Res 1997;57:1690-1694.
    • (1997) Cancer Res , vol.57 , pp. 1690-1694
    • Nikiforov, Y.E.1    Rowland, J.M.2    Bove, K.E.3
  • 17
    • 0036295515 scopus 로고    scopus 로고
    • Molecular mechanisms of RET activation in human cancer
    • Santoro M, Melillo RM, Carlomagno F, et al. Molecular mechanisms of RET activation in human cancer. Ann N Y Acad Sci 2002;963:116-121.
    • (2002) Ann N Y Acad Sci , vol.963 , pp. 116-121
    • Santoro, M.1    Melillo, R.M.2    Carlomagno, F.3
  • 18
    • 0036098222 scopus 로고    scopus 로고
    • Perspective: Lessons learned from molecular genetic studies of thyroid cancer - insights into pathogenesis and tumor-specific therapeutic targets
    • Fagin JA. Perspective: lessons learned from molecular genetic studies of thyroid cancer - insights into pathogenesis and tumor-specific therapeutic targets. Endocrinology 2002;143:2025-2028.
    • (2002) Endocrinology , vol.143 , pp. 2025-2028
    • Fagin, J.A.1
  • 19
    • 0030898417 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways
    • Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 1997;9:180-186.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 180-186
    • Robinson, M.J.1    Cobb, M.H.2
  • 20
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • Xing M. BRAF mutation in thyroid cancer. Endocr Relat Cancer 2005;12:245-262.
    • (2005) Endocr Relat Cancer , vol.12 , pp. 245-262
    • Xing, M.1
  • 21
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002;417:949-954.
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 22
    • 28044443680 scopus 로고    scopus 로고
    • Alterations of the BRAF gene in thyroid tumors
    • Ciampi R, Nikiforov YE. Alterations of the BRAF gene in thyroid tumors. Endocr Pathol 2005;16:163-172.
    • (2005) Endocr Pathol , vol.16 , pp. 163-172
    • Ciampi, R.1    Nikiforov, Y.E.2
  • 23
    • 0041589377 scopus 로고    scopus 로고
    • High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines
    • Xu X, Quiros RM, Gattuso P, et al. High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. Cancer Res 2003;63:4561-4567.
    • (2003) Cancer Res , vol.63 , pp. 4561-4567
    • Xu, X.1    Quiros, R.M.2    Gattuso, P.3
  • 24
    • 10744222003 scopus 로고    scopus 로고
    • BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas
    • Nikiforova MN, Kimura ET, Gandhi M, et al. BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. J Clin Endocrinol Metab 2003;88:5399-5404.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5399-5404
    • Nikiforova, M.N.1    Kimura, E.T.2    Gandhi, M.3
  • 25
    • 28744442816 scopus 로고    scopus 로고
    • BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer
    • Xing M, Westra WH, Tufano RP, et al. BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. J Clin Endocrinol Metab 2005;90:6373-6379.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6373-6379
    • Xing, M.1    Westra, W.H.2    Tufano, R.P.3
  • 26
    • 0141453014 scopus 로고    scopus 로고
    • Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers
    • Namba H, Nakashima M, Hayashi T, et al. Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers. J Clin Endocrinol Metab 2003;88:4393-4397.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4393-4397
    • Namba, H.1    Nakashima, M.2    Hayashi, T.3
  • 27
    • 8144230516 scopus 로고    scopus 로고
    • BRAF mutations in anaplastic thyroid carcinoma: Implications for tumor origin, diagnosis and treatment
    • Begum S, Rosenbaum E, Henrique R, et al. BRAF mutations in anaplastic thyroid carcinoma: implications for tumor origin, diagnosis and treatment. Mod Pathol 2004;17:1359-1363.
    • (2004) Mod Pathol , vol.17 , pp. 1359-1363
    • Begum, S.1    Rosenbaum, E.2    Henrique, R.3
  • 28
    • 6044219917 scopus 로고    scopus 로고
    • Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer
    • Frattini M, Ferrario C, Bressan P, et al. Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer. Oncogene 2004;23:7436-7440.
    • (2004) Oncogene , vol.23 , pp. 7436-7440
    • Frattini, M.1    Ferrario, C.2    Bressan, P.3
  • 29
    • 0037379904 scopus 로고    scopus 로고
    • High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
    • Kimura ET, Nikiforova MN, Zhu Z, et al. High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 2003;63:1454-1457.
    • (2003) Cancer Res , vol.63 , pp. 1454-1457
    • Kimura, E.T.1    Nikiforova, M.N.2    Zhu, Z.3
  • 30
    • 0043170833 scopus 로고    scopus 로고
    • BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC
    • Soares P, Trovisco V, Rocha AS, et al. BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC. Oncogene 2003;22:4578-4580.
    • (2003) Oncogene , vol.22 , pp. 4578-4580
    • Soares, P.1    Trovisco, V.2    Rocha, A.S.3
  • 31
    • 0346256746 scopus 로고    scopus 로고
    • RET rearrangements in archival oxyphilic thyroid tumors: New insights in tumorigenesis and classification of Hurthle cell carcinomas?
    • Musholt PB, Imkamp F, von WR, et al. RET rearrangements in archival oxyphilic thyroid tumors: new insights in tumorigenesis and classification of Hurthle cell carcinomas? Surgery 2003;134:881-889.
    • (2003) Surgery , vol.134 , pp. 881-889
    • Musholt, P.B.1    Imkamp, F.2    von, W.R.3
  • 32
    • 17744373683 scopus 로고    scopus 로고
    • Prevalence and distribution of ret/ptc 1, 2, and 3 in papillary thyroid carcinoma in New Caledonia and Australia
    • Chua EL, Wu WM, Tran KT, et al. Prevalence and distribution of ret/ptc 1, 2, and 3 in papillary thyroid carcinoma in New Caledonia and Australia. J Clin Endocrinol Metab 2000;85:2733-2739.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2733-2739
    • Chua, E.L.1    Wu, W.M.2    Tran, K.T.3
  • 33
    • 14344250602 scopus 로고    scopus 로고
    • Searching for RET/PTC rearrangements and BRAF V599E mutation in thyroid aspirates might contribute to establish a preoperative diagnosis of papillary thyroid carcinoma
    • Domingues R, Mendonca E, Sobrinho L, et al. Searching for RET/PTC rearrangements and BRAF V599E mutation in thyroid aspirates might contribute to establish a preoperative diagnosis of papillary thyroid carcinoma. Cytopathology 2005;16:27-31.
    • (2005) Cytopathology , vol.16 , pp. 27-31
    • Domingues, R.1    Mendonca, E.2    Sobrinho, L.3
  • 34
    • 9144219691 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in papillary thyroid carcinoma in a Korean population
    • Kim KH, Kang DW, Kim SH, et al. Mutations of the BRAF gene in papillary thyroid carcinoma in a Korean population. Yonsei Med J 2004;45:818-821.
    • (2004) Yonsei Med J , vol.45 , pp. 818-821
    • Kim, K.H.1    Kang, D.W.2    Kim, S.H.3
  • 35
    • 1942470097 scopus 로고    scopus 로고
    • Mutational analysis of BRAF in fine needle aspiration biopsies of the thyroid: A potential application for the preoperative assessment of thyroid nodules
    • Cohen Y, Rosenbaum E, Clark DP, et al. Mutational analysis of BRAF in fine needle aspiration biopsies of the thyroid: a potential application for the preoperative assessment of thyroid nodules. Clin Cancer Res 2004;10:2761-2765.
    • (2004) Clin Cancer Res , vol.10 , pp. 2761-2765
    • Cohen, Y.1    Rosenbaum, E.2    Clark, D.P.3
  • 37
    • 0142135475 scopus 로고    scopus 로고
    • BRAF mutations in papillary carcinomas of the thyroid
    • Fukushima T, Suzuki S, Mashiko M, et al. BRAF mutations in papillary carcinomas of the thyroid. Oncogene 2003;22:6455-6457.
    • (2003) Oncogene , vol.22 , pp. 6455-6457
    • Fukushima, T.1    Suzuki, S.2    Mashiko, M.3
  • 38
    • 2442568538 scopus 로고    scopus 로고
    • BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas
    • Puxeddu E, Moretti S, Elisei R, et al. BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas. J Clin Endocrinol Metab 2004;89:2414-2420.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2414-2420
    • Puxeddu, E.1    Moretti, S.2    Elisei, R.3
  • 39
    • 6344231395 scopus 로고    scopus 로고
    • Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of papillary thyroid carcinoma
    • Salvatore G, Giannini R, Faviana P, et al. Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of papillary thyroid carcinoma. J Clin Endocrinol Metab 2004;89:5175-5180.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5175-5180
    • Salvatore, G.1    Giannini, R.2    Faviana, P.3
  • 40
    • 1142287286 scopus 로고    scopus 로고
    • BRAF mutations are associated with some histological types of papillary thyroid carcinoma
    • Trovisco V, Vieira dC I, Soares P, et al. BRAF mutations are associated with some histological types of papillary thyroid carcinoma. J Pathol 2004;202:247-251.
    • (2004) J Pathol , vol.202 , pp. 247-251
    • Trovisco, V.1    Vieira dC, I.2    Soares, P.3
  • 41
    • 17844407157 scopus 로고    scopus 로고
    • RET/PTC rearrangements in thyroid nodules: Studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults
    • Elisei R, Romei C, Vorontsova T, et al. RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults. J Clin Endocrinol Metab 2001;86:3211-3216.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3211-3216
    • Elisei, R.1    Romei, C.2    Vorontsova, T.3
  • 42
    • 0033985035 scopus 로고    scopus 로고
    • Gene rearrangement and Chernobyl related thyroid cancers
    • Santoro M, Thomas GA, Vecchio G, et al. Gene rearrangement and Chernobyl related thyroid cancers. Br J Cancer 2000;82:315-322.
    • (2000) Br J Cancer , vol.82 , pp. 315-322
    • Santoro, M.1    Thomas, G.A.2    Vecchio, G.3
  • 43
    • 0031773504 scopus 로고    scopus 로고
    • RET/PTC and RET tyrosine kinase expression in adult papillary thyroid carcinomas
    • Learoyd DL, Messina M, Zedenius J, et al. RET/PTC and RET tyrosine kinase expression in adult papillary thyroid carcinomas. J Clin Endocrinol Metab 1998;83:3631-3635.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3631-3635
    • Learoyd, D.L.1    Messina, M.2    Zedenius, J.3
  • 44
    • 0035986363 scopus 로고    scopus 로고
    • Nikiforov YE. RET/PTC rearrangement in thyroid tumors. Endocr Pathol 2002;13:3-16.
    • Nikiforov YE. RET/PTC rearrangement in thyroid tumors. Endocr Pathol 2002;13:3-16.
  • 45
    • 0031933680 scopus 로고    scopus 로고
    • RET/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotypes
    • Tallini G, Santoro M, Helie M, et al. RET/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotypes. Clin Cancer Res 1998;4:287-294.
    • (1998) Clin Cancer Res , vol.4 , pp. 287-294
    • Tallini, G.1    Santoro, M.2    Helie, M.3
  • 46
    • 0034016275 scopus 로고    scopus 로고
    • Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: Biological, phenotypic, and clinical implications
    • Rabes HM, Demidchik EP, Sidorow JD, et al. Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications. Clin Cancer Res 2000;6:1093-1103.
    • (2000) Clin Cancer Res , vol.6 , pp. 1093-1103
    • Rabes, H.M.1    Demidchik, E.P.2    Sidorow, J.D.3
  • 47
    • 0033331028 scopus 로고    scopus 로고
    • High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: A strong correlation between RET/PTC3 and the solid-follicular variant
    • Thomas GA, Bunnell H, Cook HA, et al. High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant. J Clin Endocrinol Metab 1999;84:4232-4238.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 4232-4238
    • Thomas, G.A.1    Bunnell, H.2    Cook, H.A.3
  • 48
    • 33645232222 scopus 로고    scopus 로고
    • Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas
    • Adeniran AJ, Zhu Z, Gandhi M, et al. Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas. Am J Surg Pathol 2006;30:216-222.
    • (2006) Am J Surg Pathol , vol.30 , pp. 216-222
    • Adeniran, A.J.1    Zhu, Z.2    Gandhi, M.3
  • 49
    • 0031931662 scopus 로고    scopus 로고
    • RET/NTRK1 rearrangements in thyroid gland tumors of the papillary carcinoma family: Correlation with clinicopathological features
    • Bongarzone I, Vigneri P, Mariani L, et al. RET/NTRK1 rearrangements in thyroid gland tumors of the papillary carcinoma family: correlation with clinicopathological features. Clin Cancer Res 1998;4:223-228.
    • (1998) Clin Cancer Res , vol.4 , pp. 223-228
    • Bongarzone, I.1    Vigneri, P.2    Mariani, L.3
  • 50
    • 9344257862 scopus 로고    scopus 로고
    • Age-related activation of the tyrosine kinase receptor protooncogenes RET and NTRK1 in papillary thyroid carcinoma
    • Bongarzone I, Fugazzola L, Vigneri P, et al. Age-related activation of the tyrosine kinase receptor protooncogenes RET and NTRK1 in papillary thyroid carcinoma. J Clin Endocrinol Metab 1996;81:2006-2009.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 2006-2009
    • Bongarzone, I.1    Fugazzola, L.2    Vigneri, P.3
  • 51
    • 0034453001 scopus 로고    scopus 로고
    • The ret/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults
    • Fenton CL, Lukes Y, Nicholson D, et al. The ret/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults. J Clin Endocrinol Metab 2000;85:1170-1175.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1170-1175
    • Fenton, C.L.1    Lukes, Y.2    Nicholson, D.3
  • 52
    • 23844491862 scopus 로고    scopus 로고
    • RET gene rearrangements (RET/PTC1 and RET/PTC3) in papillary thyroid carcinomas from an iodine-rich country (Japan)
    • Nakazawa T, Kondo T, Kobayashi Y, et al. RET gene rearrangements (RET/PTC1 and RET/PTC3) in papillary thyroid carcinomas from an iodine-rich country (Japan). Cancer 2005;104:943-951.
    • (2005) Cancer , vol.104 , pp. 943-951
    • Nakazawa, T.1    Kondo, T.2    Kobayashi, Y.3
  • 53
    • 4544365901 scopus 로고    scopus 로고
    • Heterogeneity in the distribution of RET/PTC rearrangements within individual post-Chernobyl papillary thyroid carcinomas
    • Unger K, Zitzelsberger H, Salvatore G, et al. Heterogeneity in the distribution of RET/PTC rearrangements within individual post-Chernobyl papillary thyroid carcinomas. J Clin Endocrinol Metab 2004;89:4272-4279.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4272-4279
    • Unger, K.1    Zitzelsberger, H.2    Salvatore, G.3
  • 54
    • 33748742902 scopus 로고    scopus 로고
    • Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: Effects of the detection methods and genetic heterogeneity
    • Zhu Z, Ciampi R, Nikiforova MN, et al. Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity. J Clin Endocrinol Metab 2006;91:3603-3610.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3603-3610
    • Zhu, Z.1    Ciampi, R.2    Nikiforova, M.N.3
  • 55
    • 0031792561 scopus 로고    scopus 로고
    • Distinct multiple RET/PTC gene rearrangements in multifocal papillary thyroid neoplasia
    • Sugg SL, Ezzat S, Rosen IB, et al. Distinct multiple RET/PTC gene rearrangements in multifocal papillary thyroid neoplasia. J Clin Endocrinol Metab 1998;83:4116-4122.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 4116-4122
    • Sugg, S.L.1    Ezzat, S.2    Rosen, I.B.3
  • 56
    • 0028825189 scopus 로고
    • RET/PTC oncogene activation is an early event in thyroid carcinogenesis
    • Viglietto G, Chiappetta G, Martinez-Tello FJ, et al. RET/PTC oncogene activation is an early event in thyroid carcinogenesis. Oncogene 1995;11:1207-1210.
    • (1995) Oncogene , vol.11 , pp. 1207-1210
    • Viglietto, G.1    Chiappetta, G.2    Martinez-Tello, F.J.3
  • 57
    • 20144387455 scopus 로고    scopus 로고
    • The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
    • Melillo RM, Castellone MD, Guarino V, et al. The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells. J Clin Invest 2005;115:1068-1081.
    • (2005) J Clin Invest , vol.115 , pp. 1068-1081
    • Melillo, R.M.1    Castellone, M.D.2    Guarino, V.3
  • 58
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-7109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 59
    • 0037115405 scopus 로고    scopus 로고
    • ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases
    • Carlomagno F, Vitagliano D, Guida T, et al. ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res 2002;62:7284-7290.
    • (2002) Cancer Res , vol.62 , pp. 7284-7290
    • Carlomagno, F.1    Vitagliano, D.2    Guida, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.