Crystal structures of two H-2D(b)/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity

Immunity

Volumn 10, Issue 1, 1999, Pages 63-74

  Glithero, Ann ^a   Tormo, Jose ^b   Haurum, John S ^e   Arsequell, Gemma ^f   Valencia, Gregorio ^f   Edwards, Jon ^d   Springer, Sebastian ^d   Townsend, Alain ^d   Ya Lan, Pao ^e   Wormald, Mark ^c   Dwek, Raymond A ^c   Jones, E Yvonne ^b   Elliott, Tim ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^e DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^f DEPT OF ENVIRONMENTAL CHEMISTRY   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN RECOGNITION; ARTICLE; COMPLEX FORMATION; CROSS REACTION; CRYSTAL STRUCTURE; CYTOTOXIC T LYMPHOCYTE; PRIORITY JOURNAL;

EID: 0032983942     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80007-2     Document Type: Article

References (50)

1. Abdel-Motal, U.M., Berg, L., Rosen, A., Bengtsson, M., Thorpe, C.J., Kihlberg, J., Dahmen, J., Magnusson, G., Karlsson, K.A., and Jondal, M. (1996). Immunization with glycosylated Kb-binding peptides generates carbohydrate-specific, unrestricted cytotoxic T cells. Eur. J. Immunol. 26, 544-551.
2. Bevan, M.J. (1997). In thymic selection, peptide diversity gives and takes away. Immunity 7, 175-178.
3. Brock, R., Weismuller, K., Jung, G., and Walden, P. (1996). Molecular basis for the recognition of two structurally different major histocompatibility complex/peptide complexes by a single T cell receptor. Proc. Natl. Acad. Sci. USA 93, 13108-13113.
4. Brünger, A.T. (1992). XPLOR Version 3.1: A System for X-ray Crystallography and NMR. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT.
5. Corthay, A., Backlund, J., Broddefalk, J., Michaelsson, E., GoldschMidt, T.J., Kihlberg, J., and Holmdahl, M. (1998). Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen-induced arthritis. Eur. J. Immunol. 28, 2580-2590.
6. Deck, B., Elofsson, M., Kihlberg, J., and Unanue, E.R. (1995). Specificity of glycopeptide-specific T cells. J. Immunol. 155, 1074-1078.
7. Ding, Y.-H., Smith, K.J., Garboczi, D.N., Utz, U., Biddison, W., and Wiley, D.C. (1998). Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 8, 403-412.
8. Dudler, T., Altmann, F., Carballido, J.M., and Blaser, K. (1995). Carbohydrate-dependent, HLA class II-restricted, human T cell response to the bee venom allergen phospholipase A2 in allergic patients. Eur. J. Immunol. 25, 538-542.
9. Elliott, T.J., and Eisen, H.N. (1990). Cytotoxic T lymphocytes recognize a reconstituted class I histocompatibility antigen (HLA-A2) as an allogeneic target molecule. Proc. Natl. Acad. Sci. USA 87, 5213-5217.
10. Esnouf, R.M. (1997). An extensively modified version of molscript that includes greatly enhanced colouring capabilities. J. Mol. Graph. 15, 133-138.
11. Fielder, M., Pirt, S.J., Tarpey, I., Wilson, C., Cunningham, P., Ettelaie, C., Binder, A., Bansal, S., and Ebringer, A. (1995). Molecular mimicry and ankylosing spondylitis: Possible role of a novel sequence in pullulanase of klebsiella pneumoniae. FEBS Lett. 369, 243-248.
12. Fremont, D.H., Matsumura, M., Stura, E.A., Peterson, P.A., and Wilson, I.A. (1992). Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb. Science 257, 919-927.
13. Garboczi, D.N., Madden, D.R., and Wiley, D.C. (1994). Five viral peptide-HLA-A2 co-crystals. Simultaneous space group determination and x-ray data collection. J. Mol. Biol. 239, 581-587.
14. Garboczi, D.N., Ghosh, P., Utz, U., Fan, Q.R., Biddison, W.E., and Wiley, D.C. (1996). Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384, 134-141.
15. Garcia, K.C., Degano, M., Stanfield, R.L., Brunmark, A., Jackson, M.R., Peterson, P.A.,Teyton, L., and Wilson, I.A. (1996). An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science 274, 209-219.
16. Garcia, K.C., Degano, M., Pease, L.R., Huang, M.D., Peterson, P.A., Teyton, L., and Wilson, I.A. (1998). Structural basis of plasticity in T cell receptor recognition of a self peptide MHC antigen. Science 279, 1166-1172.
17. Hammerling, G.J., Hammerling, U., and Lemke, H. (1979). Immunogenetics 8, 433-439.
18. Harding, C.V., Kihlberg, J., Elofsson, M., Magnusson, G., and Unanue, E.R. (1993). Glycopeptides bind MHC molecules and elicit specific T cell responses. J. Immunol. 151, 2419-2425.
19. Harlos, K. (1992). Micro-bridges for sitting-drop crystallisations. J. Appl. Crystallog. 25, 536-538.
20. Hart, G.W., Haltiwanger, R.S., Holt, G.D., and Kelly, W.G. (1989). Glycosylation in the nucleus and cytoplasm. Annu. Rev. Biochem. 58, 841-874.
21. Hart, G.W., Kreppel, L., Comer, F., Arnolds, S., Snow, D., Ye, Z., Cheng, X., Dellamanna, D., Caine, D., Earles, B., et al. (1996). O-glcnacylation of key nuclear and cytoskeletal proteins: Reciprocity with O-phosphorylation and putative roles in protein multimerisation. Glycobiology 6, 711-716.
22. Haurum, J.S. (1996). Recognition Of Peptides Carrying Post-translational Modifications by Class I MHC Restricted Cytotoxic T Cells. D. Phil. Thesis, University of Oxford, Oxford, United Kingdom.
23. Haurum, J.S., Arsequell, G., Lellouch, A.C., Wong, S.Y., Dwek, R.A., McMichael, A.J., and Elliott, T. (1994). Recognition of carbohydrate by major histocompatibility complex class i-restricted, glycopeptide-specific cytotoxic T lymphocytes. J. Exp. Med. 180, 739-744.
24. Haurum, J.S., Tan, L., Arsequell, G., Frodsham, P., Lellouch, A.C., Moss, P.A., Dwek, R.A., Mcmichael, A.J., and Elliott, T. (1995). Peptide anchor residue glycosylation: Effect on class I major histocompatibility complex binding and cytotoxic T lymphocyte recognition. Eur. J. Immunol. 25, 3270-3276.
25. Jensen, T., Hansen, P., Galli-Stampino, L., Mouritsen, S., Frische, K., Meinjohanns, E., Meldal, M., and Werdelin, O. (1997). Carbohydrate and peptide specificity of MHC class II-restricted T cell hybridomas raised against an O-glycosylated self peptide. J. Immunol. 158, 3769-3778.
26. Jones, T.A. (1985). Diffraction methods for biological macromolecules: Interactive computer graphics. FRODO 115, 157-171.
27. Jones, T.A., Zhou, J.Y., Cowan, S.W., and Kjelgaard, M. (1991). Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A47, 110-119.
28. Kast, W.M., Roux, L., Curren, J., Blom, H.J., Voordouw, A.C., Meloen, R.H., Kolakofsky, D., and Melief, C.J. (1991). Protection against lethal sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide. Proc. Natl. Acad. Sci. USA 88, 2283-2287.
29. Laskowski, R.A., Macarthur, M.W., Moss, D.S., and Thornton, J.M. (1998). PROCHECK. A program to check the stereochemical quality of protein structures. J. Appl. Crystallog. 26, 283-291.
30. Madden, D.R. (1998). The three dimensional structure of peptide-MHC complexes. Annu. Rev. Immunol. 13, 587-622.
31. Mason, D. (1998). A very high level of crossreactivity is an essential feature of the T cell receptor. Immunol. Today 19, 395-404.
32. Meiboom, S., and Gill, D. (1958). Modified spin-echo method for measuring nuclear relaxation times. Rev. Sci. Instruments 29, 688-691.
33. Merritt, E.A., and Murphy, M.E.P. (1994). Raster3d version 2.0: A program for photorealistic molecular graphics. Acta Crystallogr. D50, 869-873.
34. Michaelsson, E., Malmstrom, V., Reis, S., Engstrom, A., Burkhardt, H., and Holmdahl, R. (1994). T cell recognition of carbohydrates on type II collagen. J. Exp. Med. 180, 745-749.
35. Navaza, Z. (1994). Amore - An automated package for molecular replacement. Acta Crystallogr. A50, 157-163.
36. Otwinowski, Z., and Minor, W. (1997). Processing of x-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326.
37. Quiocho, F.A. (1998). Carbohydrate-binding proteins: Tertiary structures and protein-sugar interactions. Annu. Rev. Biochem. 55, 287-315.
38. Rigney, E., Kojima, M., Glithero, A., and Elliott, T. (1998). A soluble major histocompatibility complex class I peptide-binding platform undergoes a conformational change in response to peptide epitopes. J. Biol Chem. 273, 14200-14204.
39. Rotzschke, O., Falk, K., Stevanovic, S., Jung, G., Walden, P., and Rammensee, H.G. (1991). Exact prediction of a natural T cell epitope. Eur. J. Immunol. 21, 2891-2894.
40. Sinha, A., Lopez, T., and Mcdevitt, H.O. (1990). Autoimmune disease: The failure of self tolerance. Science 248, 1380-1388.
41. Smith, K.J., Reid, S.W., Stuart, D.I., Mcmichael, A., Bell, J.I., and Jones, E.Y. (1996). Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53. Immunity 4, 215-228.
42. b upon peptide binding. Biochemistry 37, 3001-3021.
43. Steinman, L. (1996). Multiple sclerosis: A co-ordinated immunological attack against myelin in the central nervous system. Cell 85, 299-302.
44. Stuart, D.I., Levine, M., Muirhead, H., and Stammers, D.K. (1979). The crystal structure of cat pyruvate kinase at a resolution of 2.6A. J. Mol. Biol. 134, 109-142.
45. Teng, M.-K., Smolyar, A., Tse, A.G.D., Liu, J.-H., Liu, J., Hussey, R.E., Nathenson, S.G., Chang, H.-C., Reinherz, E.L., and Wang, J.-H. (1998). Identification of a common docking topology with substantial variation among different tcr-peptide-mhc complexes. Curr. Biol. 8, 409-412.
46. van Eden, W., Thole, J., van der Zee, R., Noordzij, A., van Embden, J., Hensen, E., and Cohen, I.R. (1988). Cloning of the mycobacterial epitope recognised by T lymphocytes in adjuvant arthritis. Nature 331, 171-173.
47. Wormald, M.R., Rudd, P.M., Harvey, D.J., Chang, S.C., Scragg, I.G., and Dwek, R.A. (1997). Variations in oligosaccharide-protein interactions in immunoglobulin G determine the site-specific glycosylation profiles and modulate the dynamic motion of the fc oligosaccharides. Biochemistry 36, 1370-1380.
48. Wucherpfenning, K., and Strominger, J.L. (1995). Molecular mimicry in T cell mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein. Cell 80, 695-705.
49. Young, A.C., Zhang, W., Sacchettini, J.C., and Nathenson, S.G. (1994). The three-dimensional structure of H2-Db at 2.4A resolution: Implications for antigen determinant selection. Cell 76, 39-50.
50. Zhao, X.J., and Cheung, N.K. (1995). GD2 oligosaccharide: Target for cytotoxic T lymphocytes. J. Exp. Med. 182, 67-74.