Serum- and glucocorticoid-inducible kinase 1 mediates salt sensitivity of glucose tolerance

Diabetes

Volumn 55, Issue 7, 2006, Pages 2059-2066

  Boini, Krishna M ^a   Hennige, Anita M ^a   Huang, Dan Yang ^a   Friedrich, Björn ^a   Palmada, Monica ^a   Boehmer, Christoph ^a   Grahammer, Florian ^a   Artunc, Ferruh ^a   Ullrich, Susanne ^a   Avram, Diana ^a   Osswald, Hartmut ^a   Wulff, Peer ^b   Kuhl, Dietmar ^c   Vallon, Volker ^a,d   Häring, Hans Ulrich ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

2 DOG, 2 deoxy D 1,2 3H glucose; DOCA, deoxycorticosterone acetate; GAPDH, glyceraldehyde 3 phosphate dehydrogenase; PI 3K, phosphatidylinositide 3 kinase; PKB, protein kinase B; SGK, serum and glucocorticoid inducible kinase

Indexed keywords

DEOXYCORTICOSTERONE ACETATE; DEOXYGLUCOSE; GLUCOSE; MINERALOCORTICOID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SPIRONOLACTONE; DEOXYCORTICOSTERONE; IMMEDIATE EARLY PROTEIN; PROTEIN SERINE THREONINE KINASE; SGK PROTEIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; GENE TARGETING; GENETIC TRANSFECTION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IMPAIRED GLUCOSE TOLERANCE; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; SALT INTAKE; SKELETAL MUSCLE; SODIUM BALANCE; WESTERN BLOTTING; ANIMAL; ANTIBODY SPECIFICITY; FEMALE; GENETICS; METABOLISM; MOUSE MUTANT; SEXUAL DEVELOPMENT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD GLUCOSE; DESOXYCORTICOSTERONE; FEMALE; IMMEDIATE-EARLY PROTEINS; MALE; MICE; MICE, KNOCKOUT; ORGAN SPECIFICITY; PROTEIN-SERINE-THREONINE KINASES; SEX CHARACTERISTICS; SPIRONOLACTONE;

EID: 33747077253     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db05-1038     Document Type: Article

References (64)

1. Cheng ZJ, Vaskonen T, Tikkanen I, Nurminen K, Ruskoaho H, Vapaatalo H, Muller D, Park JK, Luft FC, Mervaala EM: Endothelial dysfunction and salt-sensitive hypertension in spontaneously diabetic Goto-Kakizaki rats. Hypertension 37:433-439, 2001
2. Gaboury CL, Simonson DC, Seely EW, Hollenberg NK, Williams GH: Relation of pressor responsiveness to angiotensin II and insulin resistance in hypertension. J Clin Invest 94:2295-2300, 1994
3. Giner V, Coca A, de la Sierra A: Increased insulin resistance in salt sensitive essential hypertension. J Hum Hypertens 15:481-485, 2001
4. ter Maaten JC, Voordouw JJ, Bakker SJ, Donker AJ, Gans RO: Salt sensitivity correlates positively with insulin sensitivity in healthy volunteers. Eur J Clin Invest 29:189-195, 1999
5. Vicent D, Ilany J, Kondo T, Naruse K, Fisher SJ, Kisanuki YY, Bursell S, Yanagisawa M, King GL, Kahn CR: The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest 111:1373-1380, 2003
6. Cushman SW, Wardzala LJ: Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell: apparent translocation of intracellular transport systems to the plasma membrane. J Biol Chem 255:4758-4762, 1980
7. James DE, Pilch PF: Fractionation of endocytic vesicles and glucose-transporter-containing vesicles in rat adipocytes. Biochem J 256:725-732, 1988
8. Suzuki K, Kono T: Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site. Proc Natl Acad Sci U S A 77:2542-2545, 1980
9. Bentley J, Itchayanan D, Barnes K, McIntosh E, Tang X, Downes CP, Holman GD, Whetton AD, Owen-Lynch PJ, Baldwin SA: Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface. J Biol Chem 278:39337-39348, 2003
10. Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR: Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol 14:4902-4911, 1994
11. Haruta T, Morris AJ, Rose DW, Nelson JG, Mueckler M, Olefsky JM: Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway. J Biol Chem 270:27991-27994, 1995
12. Kotani K, Carozzi AJ, Sakaue H, Hara K, Robinson LJ, Clark SF, Yonezawa K, James DE, Kasuga M: Requirement for phosphoinositide 3-kinase in insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes. Biochem Biophys Res Commun 209:343-348, 1995
13. Okada T, Kawano Y, Sakakibara T, Hazeki O, Ui M: Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes: studies with a selective inhibitor wortmannin. J Biol Chem 269:3568-3573, 1994
14. Perrini S, Natalicchio A, Laviola L, Belsanti G, Montrone C, Cignarelli A, Minielli V, Grano M, De Pergola G, Giorgino R, Giorgino F: Dehydroepiandrosterone stimulates glucose uptake in human and murine adipocytes by inducing GLUT1 and GLUT4 translocation to the plasma membrane. Diabetes 53:41-52, 2004
15. Khan AH, Pessin JE: Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia 45:1475-1483, 2002
16. Lang F, Cohen P: Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms (Review). Sci STKE 2001:RE17, 2001
17. Virkamaki A, Ueki K, Kahn CR: Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance (Review). J Clin Invest 103:931-943, 1999
18. Foran PG, Fletcher LM, Oatey PB, Mohammed N, Dolly JO, Tavare JM: Protein kinase B stimulates the translocation of GLUT4 but not GLUT1 or transferrin receptors in 3T3-L1 adipocytes by a pathway involving SNAP-23, synaptobrevin-2, and/or cellubrevin. J Biol Chem 274:28087-28095, 1999
19. Zhou QL, Park JG, Jiang ZY, Holik JJ, Mitra P, Semiz S, Guilherme A, Powelka AM, Tang X, Virbasius J, Czech MP: Analysis of insulin signalling by RNAi-based gene silencing. Biochem Soc Trans 32:817-821, 2004
20. Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR: The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J 20:4380-4390, 2001
21. Kobayashi T, Cohen P: Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem J 339:319-328, 1999
22. Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA: Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 18:3024-3033, 1999
23. Lang F, Henke G, Embark HM, Waldegger S, Palmada M, Bohmer C, Vallon V: Regulation of channels by the serum and glucocorticoid-inducible kinase - implications for transport, excitability and cell proliferation. Cell Physiol Biochem 13:41-50, 2003
24. Dieter M, Palmada M, Rajamanickam J, Aydin A, Busjahn A, Boehmer C, Luft FC, Lang F: Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB. Obes Res 12:862-870, 2004
25. Firestone GL, Giampaolo JR, O'Keeffe BA: Stimulus-dependent regulation of the serum and glucocorticoid inducible protein kinase (Sgk) transcription, subcellular localization and enzymatic activity. Cell Physiol Biochem 13:1-12, 2003
26. Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL: Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol 13:2031-2040, 1993
27. Waldegger S, Barth P, Raber G, Lang F: Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. Proc Natl Acad Sci U S A 94:4440-4445, 1997
28. Bhargava A, Fullerton MJ, Myles K, Purdy TM, Funder JW, Pearce D, Cole TJ: The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action. Endocrinology 142:1587-1594, 2001
29. Brennan FE, Fuller PJ: Rapid upregulation of serum and glucocorticoid-regulated kinase (sgk) gene expression by corticosteroids in vivo. Mol Cell Endocrinol 166:129-136, 2000
30. Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, Buse P, Firestone GL, Verrey F, Pearce D: Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci U S A 96:2514-2519, 1999
31. Djelidi S, Beggah A, Courtois-Coutry N, Fay M, Cluzeaud F, Viengchareun S, Bonvalet JP, Farman N, Blot-Chabaud M: Basolateral translocation by vasopressin of the aldosterone-induced pool of latent Na-K-ATPases is accompanied by alpha1 subunit dephosphorylation: study in a new aldosterone-sensitive rat cortical collecting duct cell line. J Am Soc Nephrol 12:1805-1818, 2001
32. Loffing J, Zecevic M, Feraille E, Kaissling B, Asher C, Rossier BC, Firestone GL, Pearce D, Verrey F: Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. Am J Physiol Renal Physiol 280:F675-F682, 2001
33. Naray-Fejes-Toth A, Canessa C, Cleaveland ES, Aldrich G, Fejes-Toth G: sgk is an aldosterone-induced kinase in the renal collecting duct: effects on epithelial na+ channels. J Biol Chem 274:16973-16978, 1999
34. Pearce D: SGK1 regulation of epithelial sodium transport. Cell Physiol Biochem 13:13-20, 2003
35. Shigaev A, Asher C, Latter H, Garty H, Reuveny E: Regulation of sgk by aldosterone and its effects on the epithelial Na(+) channel. Am J Physiol Renal Physiol 278:F613-F619, 2000
36. + transport regulation in distal kidney nephron cells. Cell Physiol Biochem 13:21-28, 2003
37. Böhmer C, Wagner CA, Beck S, Moschen I, Melzig J, Werner A, Lin JT, Lang F, Wehner F: The shrinkage-activated Na(+) conductance of rat hepatocytes and its possible correlation to rENaC. Cell Physiol Biochem 10:187-194, 2000
38. Lang F, Klingel K, Wagner CA, Stegen C, Warntges S, Friedrich B, Lanzendorfer M, Melzig J, Moschen I, Steuer S, Waldegger S, Sauter M, Paulmichl M, Gerke V, Risler T, Gamba G, Capasso G, Kandolf R, Hebert SC, Massry SG, Broer S: Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy. Proc Natl Acad Sci U S A 97:8157-8162, 2000
39. Blazer-Yost BL, Liu X, Helman SI: Hormonal regulation of ENaCs: insulin and aldosterone. Am J Physiol 274: C1373-C1379, 1998
40. Blazer-Yost BL, Paunescu TG, Helman SI, Lee KD, Vlahos CJ: Phosphoinositide 3-kinase is required for aldosterone-regulated sodium reabsorption. Am J Physiol 277:C531-C536, 1999
41. Blazer-Yost BL, Vahle JC, Byars JM, Bacallao RL: Real-time three-dimensional imaging of lipid signal transduction: apical membrane insertion of epithelial Na(+) channels. Am J Physiol Cell Physiol 287: C1569-C1576, 2004
42. Wang J, Barbry P, Maiyar AC, Rozansky DJ, Bhargava A, Leong M, Firestone GL, Pearce D: SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. Am J Physiol Renal Physiol 280: F303-F313, 2001
43. Wulff P, Vallon V, Huang DY, Volkl H, Yu F, Richter K, Jansen M, Schlunz M, Klingel K, Loffing J, Kauselmann G, Bosl MR, Lang F, Kuhl D: Impaired renal Na(+) retention in the sgk1-knockout mouse. J Clin Invest 110:1263-1268, 2002
44. Huang DY, Wulff P, Volkl H, Loffing J, Richter K, Kuhl D, Lang F, Vallon V: Impaired regulation of renal K+ elimination in the sgk1-knockout mouse. J Am Soc Nephrol 15:885-891, 2004
45. Vallon V: In vivo studies of the genetically modified mouse kidney. Nephron Physiol 94:1-5, 2003
46. Menniti M, Iuliano R, Amato R, Boito R, Corea M, Le Pera I, Gulletta E, Fuiano G, Perrotti N: Serum and glucocorticoid-regulated kinase Sgk1 inhibits insulin-dependent activation of phosphomannomutase 2 in transfected COS-7 cells. Am J Physiol Cell Physiol 288:C148-C155, 2005
47. Cidad P, Almeida A, Bolanos JP: Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5′-AMP-activated protein kinase. Biochem J 384:629-636, 2004
48. Ogihara T, Asano T, Fujita T: Contribution of salt intake to insulin resistance associated with hypertension. Life Sci 73:509-523, 2003
49. Berger S, Bleich M, Schmid W, Cole TJ, Peters J, Watanabe H, Kriz W, Warth R, Greger R, Schutz G: Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism. Proc Natl Acad Sci U S A 95:9424-9429, 1998
50. Hummler E, Barker P, Gatzy J, Beermann F, Verdumo C, Schmidt A, Boucher R, Rossier BC: Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet 12:325-328, 1996
51. Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB: Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol 23:7315-7328, 2003
52. Taha C, Liu Z, Jin J, Al Hasani H, Sonenberg N, Klip A: Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin: role of mammalian target of rapamycin, protein kinase b, and phosphatidylinositol 3-kinase in GLUT1 mRNA translation. J Biol Chem 274:33085-33091, 1999
53. Bae SS, Cho H, Mu J, Birnbaum MJ: Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. J Biol Chem 278:49530-49536, 2003
54. Jiang ZY, Zhou QL, Coleman KA, Chouinard M, Boese Q, Czech MP: Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A 100:7569-7574, 2003
55. Kohn AD, Summers SA, Birnbaum MJ, Roth RA: Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271:31372-31378, 1996
56. McCurdy CE, Cartee GD: Akt2 is essential for the full effect of calorie restriction on insulin-stimulated glucose uptake in skeletal muscle. Diabetes 54:1349-1356, 2005
57. Nishida Y, Nagata T, Takahashi Y, Sugahara-Kobayashi M, Murata A, Asai S: Alteration of serum/glucocorticoid regulated kinase-1 (sgk-1) gene expression in rat hippocampus after transient global ischemia. Brain Res Mol Brain Res 123:121-125, 2004
58. Lee EH, Hsu WL, Ma YL, Lee PJ, Chao CC: Enrichment enhances the expression of sgk, a glucocorticoid-induced gene, and facilitates spatial learning through glutamate AMPA receptor mediation. Eur J Neurosci 18:2842-2852, 2003
59. Farjah M, Roxas BP, Geenen DL, Danziger RS: Dietary salt regulates renal SGK1 abundance: relevance to salt sensitivity in the Dahl rat. Hypertension 41:874-878, 2003
60. Palmada M, Boehmer C, Akel A, Rajamanickam J, Jeyaraj S, Keller K, Lang F: SGK1 kinase upregulates GLUT1 activity and plasma membrane expression. Diabetes 55:421-427, 2006
61. Busjahn A, Aydin A, Uhlmann R, Krasko C, Bahring S, Szelestei T, Feng Y, Dahm S, Sharma AM, Luft FC, Lang F: Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure. Hypertension 40:256-260, 2002
62. Roth JL, Mobarhan S, Clohisy M: The metabolic syndrome: where are we and where do we go? Nutr Rev 60:335-337, 2002
63. Bahr V, Pfeiffer AF, Diederich S: The metabolic syndrome X and peripheral cortisol synthesis. Exp Clin Endocrinol Diabetes 110:313-318, 2002
64. Ullrich S, Berchtold S, Ranta F, Seebohm G, Henke G, Lupescu A, Mack AF, Chao CM, Su J, Nitschke R, Alexander D, Friedrich B, Wulff P, Kuhl D, Lang F: Serum- and glucocorticoid-inducible kinase 1 (SGK1) mediates glucocorticoid-induced inhibition of insulin secretion. Diabetes 54:1090-1099, 2005