-
1
-
-
0030453986
-
Progress in the acquisition of new marine-derived anticancer compounds: Development of ecteinascidin-743 (ET -743)
-
Jimeno JM, Faircloth G, Cameron L, et al. Progress in the acquisition of new marine-derived anticancer compounds: development of ecteinascidin-743 (ET -743). Drugs Future 1996; 21:1155-1165.
-
(1996)
Drugs Future
, vol.21
, pp. 1155-1165
-
-
Jimeno, J.M.1
Faircloth, G.2
Cameron, L.3
-
2
-
-
0033566150
-
Ecteinascidin 743: A minor groove alkylator that bends DNA toward the major groove
-
Zewail-Foote M, Hurley LH. Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove. J Med Chem 1999; 42:2493-2497.
-
(1999)
J Med Chem
, vol.42
, pp. 2493-2497
-
-
Zewail-Foote, M.1
Hurley, L.H.2
-
3
-
-
0034612344
-
Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743
-
Minuzzo M, Marchini S, Broggini M, et al. Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743. Proc Natl Acad Sci U S A 2000; 97:6780-6784.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 6780-6784
-
-
Minuzzo, M.1
Marchini, S.2
Broggini, M.3
-
4
-
-
0035146702
-
Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action
-
Erba E, Bergamaschi D, Bassano L, et al. Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action. Eur J Cancer 2001; 37:97-105.
-
(2001)
Eur J Cancer
, vol.37
, pp. 97-105
-
-
Erba, E.1
Bergamaschi, D.2
Bassano, L.3
-
5
-
-
0242559104
-
Preclinical and clinical results with the natural marine product ET-743
-
D'Incalci M, Jimeno J. Preclinical and clinical results with the natural marine product ET-743. Expert Opin Investig Drugs 2003; 12:1843-1853.
-
(2003)
Expert Opin Investig Drugs
, vol.12
, pp. 1843-1853
-
-
D'Incalci, M.1
Jimeno, J.2
-
6
-
-
0142121506
-
Phase I and pharmacokinetic study of Yondelis (ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours
-
Twelves C, Hoekman K, Bowman A, et al. Phase I and pharmacokinetic study of Yondelis (ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours. Eur J Cancer 2003; 39:1842-1851.
-
(2003)
Eur J Cancer
, vol.39
, pp. 1842-1851
-
-
Twelves, C.1
Hoekman, K.2
Bowman, A.3
-
7
-
-
0035281641
-
Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors
-
Taamma A, Misset JL, Riofrio M, et al. Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors. J Clin Oncol 2001; 19:1256-1265.
-
(2001)
J Clin Oncol
, vol.19
, pp. 1256-1265
-
-
Taamma, A.1
Misset, J.L.2
Riofrio, M.3
-
8
-
-
0036154945
-
A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies
-
Villalona-Calero MA, Eckhardt SG, Weiss G, et al. A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies. Clin Cancer Res 2002; 8:75-85.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 75-85
-
-
Villalona-Calero, M.A.1
Eckhardt, S.G.2
Weiss, G.3
-
9
-
-
1542398698
-
Phase II study of ecteinascidin-743 in advanced pretreated soft tissue sarcoma patients
-
Yovine A, Riofrio M, Blay JY, et al. Phase II study of ecteinascidin-743 in advanced pretreated soft tissue sarcoma patients. J Clin Oncol 2004; 22:890-899.
-
(2004)
J Clin Oncol
, vol.22
, pp. 890-899
-
-
Yovine, A.1
Riofrio, M.2
Blay, J.Y.3
-
10
-
-
20044372153
-
Phase II study of ET-743 in advanced soft tissue sarcomas: A European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trial
-
Le Cesne A, Blay JY, Judson I, et al. Phase II study of ET-743 in advanced soft tissue sarcomas: a European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trial. J Clin Oncol 2005; 23:576-584.
-
(2005)
J Clin Oncol
, vol.23
, pp. 576-584
-
-
Le Cesne, A.1
Blay, J.Y.2
Judson, I.3
-
11
-
-
2342461682
-
Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy
-
Garcia-Carbonero R, Supko JG, Manola J, et al. Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy. J Clin Oncol 2004; 22:1480-1490.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1480-1490
-
-
Garcia-Carbonero, R.1
Supko, J.G.2
Manola, J.3
-
12
-
-
24944460785
-
Ecteinascidin-743 (ET-743) for chemotherapy-naive patients with advanced soft tissue sarcomas: Multicenter phase II and pharmacokinetic study
-
Garcia-Carbonero R, Supko JG, Maki RG, et al. Ecteinascidin-743 (ET-743) for chemotherapy-naive patients with advanced soft tissue sarcomas: multicenter phase II and pharmacokinetic study. J Clin Oncol 2005; 23:5484-5492.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5484-5492
-
-
Garcia-Carbonero, R.1
Supko, J.G.2
Maki, R.G.3
-
13
-
-
20144377216
-
Trabectedin for women with ovarian carcinoma after treatment with platinum and taxanes fails
-
Sessa C, De Braud F, Perotti A, et al. Trabectedin for women with ovarian carcinoma after treatment with platinum and taxanes fails. J Clin Oncol 2005; 23:1867-1874.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1867-1874
-
-
Sessa, C.1
De Braud, F.2
Perotti, A.3
-
14
-
-
84898691935
-
-
Del Campo J, Roszak A, Ciuleanu T, et al. Phase II open label randomized study of trabectedin (T) given as two different dosing schedules in women with platinum-sensitive, recurrent ovarian carcinoma: preliminary results. J Clin Oncol 2006; 24(18 suppl):263s (Abstract #5031).
-
Del Campo J, Roszak A, Ciuleanu T, et al. Phase II open label randomized study of trabectedin (T) given as two different dosing schedules in women with platinum-sensitive, recurrent ovarian carcinoma: preliminary results. J Clin Oncol 2006; 24(18 suppl):263s (Abstract #5031).
-
-
-
-
15
-
-
84898696550
-
-
Michaelson MD, Gilligan T, Oh W, et al. Phase II study of three hour, weekly infusion of trabectedin (ET-743) in men with metastatic, androgen-independent prostate carcinoma (AIPC). J Clin Oncol 2005; 23(16 suppl):382s (Abstract #4517).
-
Michaelson MD, Gilligan T, Oh W, et al. Phase II study of three hour, weekly infusion of trabectedin (ET-743) in men with metastatic, androgen-independent prostate carcinoma (AIPC). J Clin Oncol 2005; 23(16 suppl):382s (Abstract #4517).
-
-
-
-
16
-
-
72949113194
-
Trabectedin in third line breast cancer: A multicenter, randomized, phase II study comparing two administration regimens
-
16 suppl):34s Abstract #625
-
Gurtler JS, Goldstein L, Delprete S, et al. Trabectedin in third line breast cancer: a multicenter, randomized, phase II study comparing two administration regimens. J Clin Oncol 2005; 23(16 suppl):34s (Abstract #625).
-
(2005)
J Clin Oncol
, pp. 23
-
-
Gurtler, J.S.1
Goldstein, L.2
Delprete, S.3
-
17
-
-
33745259879
-
A phase II study of Yondelis (trabectedin, ET-743) as a 24-h continuous intravenous infusion in pretreated advanced breast cancer
-
Zelek L, Yovine A, Brain E, et al. A phase II study of Yondelis (trabectedin, ET-743) as a 24-h continuous intravenous infusion in pretreated advanced breast cancer. Br J Cancer 2006; 94:1610-1614.
-
(2006)
Br J Cancer
, vol.94
, pp. 1610-1614
-
-
Zelek, L.1
Yovine, A.2
Brain, E.3
-
18
-
-
0031733644
-
In vitro schedule-dependency of myelotoxicity and cytotoxicity of ecteinascidin 743 (ET-743)
-
Ghielmini M, Colli E, Erba E, et al. In vitro schedule-dependency of myelotoxicity and cytotoxicity of ecteinascidin 743 (ET-743). Ann Oncol 1998; 9:989-993.
-
(1998)
Ann Oncol
, vol.9
, pp. 989-993
-
-
Ghielmini, M.1
Colli, E.2
Erba, E.3
-
19
-
-
0019365237
-
Reporting results of cancer treatment
-
Miller AB, Hoogstraten B, Staquet M, et al. Reporting results of cancer treatment. Cancer 1981; 47:207-214.
-
(1981)
Cancer
, vol.47
, pp. 207-214
-
-
Miller, A.B.1
Hoogstraten, B.2
Staquet, M.3
-
20
-
-
50549174560
-
The determination of the number of patients required in a preliminary and a follow-up trial of a new chemotherapeutic agent
-
Gehan EA. The determination of the number of patients required in a preliminary and a follow-up trial of a new chemotherapeutic agent. J Chronic Dis 1961; 13:346-353.
-
(1961)
J Chronic Dis
, vol.13
, pp. 346-353
-
-
Gehan, E.A.1
-
21
-
-
0035136529
-
Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression
-
Takebayashi Y, Goldwasser F, Urasaki Y, et al. Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression. Clin Cancer Res 2001; 7:185-191.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 185-191
-
-
Takebayashi, Y.1
Goldwasser, F.2
Urasaki, Y.3
-
22
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351:337-345.
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
23
-
-
33750366159
-
Bevacizumab in the treatment of metastatic colorectal cancer (mCRC) in second- and third-line settings
-
Giantonio BJ. Bevacizumab in the treatment of metastatic colorectal cancer (mCRC) in second- and third-line settings. Semin Oncol 2006; 33(suppl 10):S15-S18.
-
(2006)
Semin Oncol
, vol.33
, Issue.SUPPL. 10
-
-
Giantonio, B.J.1
-
24
-
-
1342290189
-
FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
-
Tournigand C, Andre T, Achille E, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 2004; 22:229-237.
-
(2004)
J Clin Oncol
, vol.22
, pp. 229-237
-
-
Tournigand, C.1
Andre, T.2
Achille, E.3
-
25
-
-
19944426087
-
A phase I and pharmacokinetic study of ecteinascidin-743 (Yondelis) in children with refractory solid tumors. A Children's Oncology Group study
-
Lau L, Supko JG, Blaney S, et al. A phase I and pharmacokinetic study of ecteinascidin-743 (Yondelis) in children with refractory solid tumors. A Children's Oncology Group study. Clin Cancer Res 2005; 11:672-677.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 672-677
-
-
Lau, L.1
Supko, J.G.2
Blaney, S.3
-
26
-
-
14644423300
-
Hepatotoxicity and metabolism of trabectedin: A literature review
-
Beumer JH, Schellens JH, Beijnen JH. Hepatotoxicity and metabolism of trabectedin: a literature review. Pharmacol Res 2005; 51:391-398.
-
(2005)
Pharmacol Res
, vol.51
, pp. 391-398
-
-
Beumer, J.H.1
Schellens, J.H.2
Beijnen, J.H.3
-
27
-
-
84898691093
-
-
Yver A, Cohen R, Williams D, et al. Assessment of trabectedin (T) induced liver toxicity with correlation to liver morphology in a phase I study of T + pegylated liposomal doxorubicin (PLD). J Clin Oncol 2006; 24(18 suppl):536s (Abstract #9568).
-
Yver A, Cohen R, Williams D, et al. Assessment of trabectedin (T) induced liver toxicity with correlation to liver morphology in a phase I study of T + pegylated liposomal doxorubicin (PLD). J Clin Oncol 2006; 24(18 suppl):536s (Abstract #9568).
-
-
-
-
28
-
-
0036239748
-
Clinical pharmacology of the novel marine-derived anticancer agent ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study
-
van Kesteren C, Twelves C, Bowman A, et al. Clinical pharmacology of the novel marine-derived anticancer agent ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study. Anticancer Drugs 2002; 13:381-393.
-
(2002)
Anticancer Drugs
, vol.13
, pp. 381-393
-
-
van Kesteren, C.1
Twelves, C.2
Bowman, A.3
-
29
-
-
0035127175
-
Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies
-
Ryan DP, Supko JG, Eder JP, et al. Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies. Clin Cancer Res 2001; 7:231-242.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 231-242
-
-
Ryan, D.P.1
Supko, J.G.2
Eder, J.P.3
|