Evaluation of the catalytic mechanism of AICAR transformylase by pH-dependent kinetics, mutagenesis, and quantum chemical calculations

Journal of the American Chemical Society

Volumn 123, Issue 20, 2001, Pages 4687-4696

  Shim, J H ^a   Wall, M ^a   Benkovic, S J ^a   Diaz, N ^b   Suarez D ^a   Merz, Jr ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF OVIEDO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

QUANTUM CHEMICAL CALCULATION;

ACTIVATION ENERGY; CATALYSIS; CHEMICAL ANALYSIS; MUTAGENESIS; PH EFFECTS; PROTONS; X RAY ANALYSIS;

ENZYMES;

PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; PLASMID DNA;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME KINETICS; HYDROGEN BOND; MOLECULAR INTERACTION; PH; QUANTUM CHEMISTRY; SITE DIRECTED MUTAGENESIS;

BINDING SITES; CATALYSIS; CHEMISTRY, PHYSICAL; HYDROGEN-ION CONCENTRATION; HYDROXYMETHYL AND FORMYL TRANSFERASES; IMIDAZOLES; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; QUANTUM THEORY; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS;

EID: 0034827712     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja010014k     Document Type: Article

References (23)

1. Exchange-correlation approximation in density-functional theory