Cooperative inhibitory effects of budesonide and formoterol on eosinophil superoxide production stimulated by bronchial epithelial cell conditioned medium

International Archives of Allergy and Immunology

Volumn 143, Issue 3, 2007, Pages 201-210

  Persdotter, Sofia ^a   Lindahl, Maria ^a   Malm Erjefält, Monika ^a   Von Wachenfeldt, Karin ^a   Korn, Solange H ^a   Stevens, Tim ^a   Miller Larsson, Anna ^a,b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Asthma; Bronchial epithelial cell; Budesonide; Combination therapy; Eosinophil; Formoterol; Granulocyte macrophage colony stimulating factor; Superoxide

Indexed keywords

BUDESONIDE; CYTOCHROME C; FORMOTEROL; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BRONCHUS MUCOSA; CELL CULTURE; CELL STIMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EOSINOPHIL; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ASTHMA; BRONCHI; BRONCHODILATOR AGENTS; BUDESONIDE; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINOPHILS; EPITHELIAL CELLS; ETHANOLAMINES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; SUPEROXIDES;

EID: 34250318594     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000099463     Document Type: Article

References (55)

1. Greening AP, Wind P, Northfield M, Shaw G: Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Lancet 1994;344:219-224.
2. Pauwels RA, Löfdahl CG, Postma DS, Tattersfield AE, O'Byrne P, Barnes PJ, Ullman A: Effect of inhaled formoterol and budesonide on exacerbations of asthma. N Engl J Med 1997;337:1405-1411.
3. Shrewsbury S, Pyke S, Britton M: Meta-analysis of increased dose of inhaled steroid or addition of salmeterol in symptomatic asthma (MIASMA). Br Med J 2000;320:1368-1373.
4. O'Byrne PM, Barnes PJ, Rodriguez-Roisin R, Runnerström E, Sandström T, Svensson K, Tattersfield A: Low dose inhaled budesonide and formoterol in mild persistent asthma: the OPTIMA randomized trial. Am J Respir Crit Care Med 2001:164:1392-1397.
5. Matz J, Emmett A, Rickard K, Kalberg C: Addition of salmeterol to low-dose fluticasone: an analysis of asthma exacerbations. J Allergy Clin Immunol 2001;107:783-789.
6. 2-agonists and corticosteroids on tumor necrosis factor-α-induced interleukin-8 release from cultured human airway smoothmuscle cells. Am J Respir Cell Mol Biol 2000;23:79-85.
7. 2-agonists and corticosteroids. FASEB J 2001;15:261-269.
8. Korn SH, Jerre A, Brattsand R: Effects of formoterol and budesonide on GM-CSF and IL-8 secretion by triggered human bronchial epithelial cells. Eur Respir J 2001;17:1070-1077.
9. Silvestri M, Fregonese L, Sabatini F, Dasic G, Rossi GA: Fluticasone and salmeterol downregulate in vitro, fibroblast proliferation and ICAM-1 or H-CAM expression. Eur Respir J 2001;18:139-145.
10. Spoelstra FM, Postma DS, Hovenga H, Noordhoek JA, Kauffman HF: Additive antiinflammatory effect of formoterol and budesonide on human lung fibroblasts. Thorax 2002;57:237-241.
11. 2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling. Lancet 2002;360:1293-1299.
12. Goncharova EA, Billington CK, Irani C, Vorotnikov AV, Tkachuk VA, Penn RB, Krymskaya VP, Panettieri RA Jr: Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration. Am J Respir Crit Care Med 2003;29:19-27.
13. Todorova L, Gürcan E, Miller-Larsson A, Westergren-Thorsson G: Lung fibroblast proteoglycan production induced by serum is inhibited by budesonide and formoterol. Am J Respir Cell Mol Biol 2006;34:92-100.
14. Edwards MR, Johnson MW, Johnston SL: Combination therapy: synergistic suppression of virus-induced chemokines in airway epithelial cells. Am J Respir Cell Mol Biol 2006;34:616-624.
15. Rabe KF, Giembycz MA, Dent G, Perkins RS, Evans P, Barnes P: Salmeterol is a competitive antagonist at β-adrenoceptors mediating inhibition of respiratory burst in guineapig eosinophils. Eur J Pharmacol 1993;231:305-308.
16. Ezeamuzie CI, al-Hage M, Nwankwoala RNP: The effect of salmeterol on human eosinophils is both stimulus- and response-dependent. Int J Immunopharmacol 1997;19:421-430.
17. Ezeamuzie CI, al-Hage M: Differential effects of salbutamol and salmeterol on human eosinophil responses. J Pharmacol Exp Ther 1998;284:25-31.
18. Ezeamuzie CI, al-Hage M: Effects of some anti-asthma drugs on human eosinophil superoxide anions release and degranulation. Int Arch Allergy Immunol 1998;115:162-168.
19. 2-agonists on human granulocyte functions. Int Arch Allergy Immunol 2005;139:1-8.
20. Okada C, Sugiyama H, Eda R, Miyagawa H, Hopp RJ, Bewtra AK, Townley RG: Effects of formoterol on superoxide anion generation from bronchoalveolar lavage cells after antigen challenge in guinea pigs. Am J Respir Cell Biol 1993;8:509-517.
21. Nielson CP, Hadjokas NE: Beta-Adrenoceptor agonists block corticosteroid inhibition in eosinophils. Am J Respir Crit Care Med 1998;157:184-191.
22. Barnes PJ: Reactive oxygen species and airway inflammation. Free Radic Biol Med 1990;9:235-243.
23. Henricks PAJ, Nijkamp FP: Reactive oxygen species as mediators in asthma. Pulm Pharmacol Ther 2001;14:409-421.
24. Rahman I: Oxidative stress, chromatin remodelling and gene transcript in inflammation and chronic lung diseases. J Biochem Mol Biol 2003;36:95-109.
25. Fujisawa T: Role of oxygen radicals on bronchial asthma. Curr Drug Targets Inflamm Allergy 2005;4:505-509.
26. Kato M, Hayashi Y, Kimura H: Oxygen radicals in inflammation and allergy related to viral infections. Curr Drug Targets Inflamm Allergy 2005;4:497-501.
27. Sedgwick JB, Geiger KM, Busse WW: Superoxide generation by hypodense eosinophils from patients with asthma. Am Rev Respir Dis 1990;142:120-125.
28. Sanders SP, Zweier JL, Harrison SJ, Trush MA, Rembish SJ, Liu MC: Spontaneous oxygen radical production at sites of antigen challenge in allergic subjects. Am J Respir Crit Care Med 1995;151:1725-1733.
29. Smith LJ, Shamsuddin M, Sporn PH, Denenberg M, Anderson J: Reduced superoxide dismutase in lung cells of patients with asthma. Free Radic Biol Med 1997;22:1301-1307.
30. Comhair SA, Ricci KS, Arroliga M, Lara AR, Dweik RA, Song W, Hazen SL, Bleecker ER, Busse WW, Chung KF, Gaston B, Hastie A, Hew M, Jarjour N, Moore W, Peters S, Teague WG, Wenzel SE, Erzurum SC: Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma. Am J Respir Crit Care Med 2005;172:306-313.
31. Comhair SA, Xu W, Ghosh S, Thunnissen FB, Almasan A, Calhoun WJ, Janocha AJ, Zheng L, Hazen SL, Erzurum SC: Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity. Am J Pathol 2005;166:663-674.
32. Nijkamp FP, Henricks PA: Receptors in airway disease. Beta-Adrenoceptors in lung inflammation. Am Rev Respir Dis 1990;141:S145-S150.
33. Hutchison KA, Matić G, Meshinchi S, Bresnick EH, Pratt WB: Redox manipulation of DNA binding activity and BuGR epitope reactivity of the glucocorticoid receptor. J Biol Chem 1991;266:10505-10509.
34. Okamoto K, Tanaka H, Ogawa H, Makino Y, Eguchi H, Hayashi S, Yoshikawa N, Poellinger L, Umesono K, Makino I: Redox-dependent regulation of nuclear import of the glucocorticoid receptor. J Biol Chem 1999;274:10363-10371.
35. Hansel TT, de Vries IJM, Iff T, Rihs S, Wandzilak M, Betz S, Blaser K, Walker C: An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils. J Immunol Methods 1991;145:105-110.
36. Horie S, Gleich GJ, Kita H: Cytokines directly induce degranulation and superoxide production from human eosinophils. J Allergy Clin Immunol 1996;98:371-381.
37. Babior BM, Kipnes RS, Curnutte JT: The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest 1973;52:41-44.
38. Chihara J, Kakazu T, Higashimoto I, Yamamoto T, Kurachi D, Nakajima S: Increased eosinophil oxidative metabolism by treatment with soluble intercellular adhesion molecule-1. Int Arch Allergy Immunol 1995;108(suppl 1):45-47.
39. Heiman AS, Allen-Gipson D: Cytokines potentiate human eosinophil superoxide generation in the presence of Nω-nitro-L-arginine methyl ester. Int J Immunopharmacol 2000;22:171-181.
40. Sannohe S, Adachi T, Hamada K, Honda K, Yamada Y, Saito N, Cui CH, Kayaba H, Ishikawa K, Chihara J: Upregulated response to chemokines in oxidative metabolism of eosinophils in asthma and allergic rhinitis. Eur Respir J 2003;21:925-931.
41. Abdelaziz MM, Devalia JL, Khair OA, Calderon M, Sapsford RJ, Davies RJ: The effect of conditioned medium from cultured human bronchial epithelial cells on eosinophil and neutrophil chemotaxis and adherence in vitro. Am J Respir Cell Mol Biol 1995;13:728-737.
42. Roca-Ferrer J, Mullol J, Lopez E, Exaubet A, Pujols L, Fernandez J, Picado C: Effect of topical anti-inflammatory drugs on epithelial cell-induced eosinophil survival and GM-CSF secretion. Eur Respir J 1997;10:1489-1495.
43. Horie S, Kita H: CD11b/CD18 (Mac-1) is required for degranulation of human eosinophils induced by human recombinant granulocyte-macrophage colony-stimulating factor and platelet-activating factor. J Immunol 1994;152:5457-5467.
44. Nagata M, Sedgwick JB, Busse WW: Differential effects of granulocyte-macrophage colony-stimulating factor on eosinophil and neutrophil superoxide anion generation. J Immunol 1995;155:4948-4954.
45. Lynch OT, Giembycz MA, Barnes PJ, Hellewell PG, Lindsay MA: 'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils. Br J Pharmacol 1999;128:1149-1158.
46. Suzuki M, Kato M, Hanaka H, Izumi T, Morikawa A: Actin assembly is a crucial factor for superoxide anion generation from adherent human eosinophils. J Allergy Clin Immunol 2003;112:126-133.
47. Liochev SI, Fridovich I: Lucigenin as mediator of superoxide production: revisited. Free Radic Biol Med 1998;25:926-928.
48. Kopprasch S, Pietzsch J, Graessler J: Validation of different chemilumigenic substrates for detecting extracellular generation of reactive oxygen species by phagocytes and endothelial cells. Luminescence 2003;18:268-273.
49. Sugimoto Y, Ogawa M, Tai N, Kamei C: Inhibitory effects of glucocorticoids on rat eosinophil superoxide generation and chemotaxis. Int Immunopharmacol 2003;3:845-852.
50. 2 production. Lung 1999;177:219-228.
51. 2-agonists and corticosteroids. Eur Respir J 2002;19:182-191.
52. Ehrhardt C, Kneuer C, Bies C, Lehr CM, Kim KJ, Bakowsky U: Salbutamol is actively absorbed across human bronchial epithelial cell layers. Pulm Pharmacol Ther 2005;18:165-170.
53. Horvath G, Schmid N, Fragoso MA, Schmid A, Conner GE, Salathe M, Wanner A: Epithelial organic cation transporters ensure pH dependent drug absorption in the airway. Am J Respir Cell Mol Biol 2007;36:53-60.
54. Spoelstra FM, Kauffman HF, Hovenga H, Noordhoek JA, de Monchy JG, Postma DS: Effects of budesonide and formoterol on eosinophil activation induced by human lung fibroblasts. Am J Respir Crit Care Med 2000;162:1229-1234.
55. Kobayashi T, Seguchi H: Novel insight into current models of NADPH oxidase regulation, assembly and localization in human polymorphonuclear leukocytes. Histol Histopathol 1999;14:1295-1308.