Effects of budesonide and formoterol on eosinophil activation induced by human lung fibroblasts

American Journal of Respiratory and Critical Care Medicine

Volumn 162, Issue 4 I, 2000, Pages 1229-1234

  Spoelstra, Fokje M ^a   Kauffman, Henk F ^a   Hovenga, Hessel ^a   Noordhoek, Jacobien A ^a   De Monchy, Jan G R ^a   Postma, Dirkje S ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; CD11 ANTIGEN; FORMOTEROL; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; SELECTIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CELL ACTIVATION; CELL STIMULATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EOSINOPHIL; HUMAN; HUMAN CELL; INCUBATION TIME; LUNG FIBROBLAST; PRIORITY JOURNAL; TARGET CELL;

EID: 0033773860     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.162.4.9911077     Document Type: Article

References (29)

1. Inflammation of small airways in asthma
2. Granulocyte-macrophage colony-stimulating factor, eosinophils and eosinophil cationic protein in subjects with and without mild, stable, atopic asthma
3. Immunophenotyping of eosinophils recovered from blood and BAL of allergic asthmatics
4. Blood and bronchoalveolar eosinophils in allergic subjects after segmental antigen challenge: Surface phenotype, density heterogeneity, and prostanoid production
5. Changes in CD11b and L-selectin expression on eosinophils are mediated by human lung fibroblasts in vitro
6. Effect of inhaled budesonide on lung function and airway inflammation: Assessment by various inflammatory markers in mild asthma
7. Effects of inhaled budesonide on allergen-induced airway responses and airway inflammation
8. The effects of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indices in mild asthma
9. Formoterol compared with beclomethasone and placebo on allergen-induced asthmatic responses
10. Effect of inhaled formoterol and budesonide on exacerbations of asthma
11. Dexamethasone inhibits prolonged survival and autocrine granulocyte macrophage colony-stimulating factor production by human eosinophils cultured on laminin or tissue fibronectin
12. Interleukin-3-induced up-regulation of CR3 expression on human eosinophils is inhibited by dexamethasone
13. Beta-adrenoceptor agonists block corticosteroid inhibition in eosinophils
14. Glucocorticoids inhibit chemokine generation by human eosinophils
15. IL-5 as a strong secretagogue for human eosinophils
16. Effect of topical anti-inflammatory drugs on epithelial cell-induced eosinophil survival and GM-CSF secretion
17. Eosinophil locomotion and the release of IL-3 and IL-5 by allergen-stimulated mononuclear cells are effectively downregulated in vitro by budesonide
18. Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro
19. 4
20. Increased cAMP levels in stimulated neutrophils inhibit their adhesion to human bronchial epithelial cells
21. An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils
22. Effects of topical anti-inflammatory drugs on eosinophil survival primed by epithelial cells: Additive effect of glucocorticoids and nedocromil sodium
23. Glucocorticoids downregulate gene expression of GM-CSF, NAP-1/IL-8, and IL-6, but not of M-CSF in human fibroblasts
24. Transcriptional cross-talk: Nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun
25. Antisense oligonucleotides to the p65 subunit of NF-kappa B block CD11b expression and alter adhesion properties of differentiated HL-60 granulocytes
26. Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors
27. Hydroxamate-based metalloprotease inhibitor blocks shedding of L-selectin adhesion molecule from leukocytes - Functional consequences for neutrophil aggregation
28. Inhibitory effects of formoterol on platelet-activating factor induced eosinophil chemotaxis and degranulation
29. Effect of inhaled glucocorticoid on the cellular profile and cytokine levels in induced sputum from asthmatic patients