Anti-inflammatory and antinociceptive properties of blueberry extract (Vaccinium corymbosum)

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 4, 2007, Pages 591-596

  Torri, Eliane ^a   Lemos, Marivane ^a   Caliari, Vinícius ^c   Kassuya, Cândida A L ^a   Bastos, Jairo K ^d   Andrade, Sérgio F ^a,b  

^a Área de Ciências Biológicas e da Saúde   (Brazil)

^b UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

^c EMPRESA DE PESQUISA AGROPECUÁRIA E EXTENSÃO RURAL DE SANTA CATARINA   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; DEXAMETHASONE; FORMALDEHYDE; HISTAMINE; HYDROXYZINE; INDOMETACIN; MYELOPEROXIDASE; PLANT EXTRACT; UNCLASSIFIED DRUG; VACCINIUM CORYMBOSUM EXTRACT; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; PEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVITY; MALE; NONHUMAN; PAW EDEMA; RAT; VACCINIUM; VACCINIUM CORYMBOSUM; ABDOMEN; ANIMAL; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DOSE RESPONSE; EDEMA; FOREIGN BODY GRANULOMA; FRUIT; METABOLISM; PAIN ASSESSMENT; PHYSIOLOGY; PHYTOTHERAPY; STENOSIS, OCCLUSION AND OBSTRUCTION; WISTAR RAT;

ABDOMEN; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CONSTRICTION, PATHOLOGIC; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; FRUIT; GRANULOMA, FOREIGN-BODY; HISTAMINE; INDOMETHACIN; MALE; PAIN MEASUREMENT; PEROXIDASE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR; VACCINIUM;

EID: 34250216375     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.4.0015     Document Type: Article

References (39)

1. Badilla, B., Arias, A. Y., Arias, M., Mora, G. A., Poveda, L. J. (2003) Anti-inflammatory and antinociceptive activities of Losa speciosa in rats and mice. Fitoterapia 74: 45-51
2. Bars, D., Gozariu, M., Cadden, S. W. (2001) Animal models of nociception. Pharmacol. Rev. 53: 597-652
3. st edn, American Botanical Council, Newton, MA, USA, p. 519
4. Bradley, P. B., Pribat, D. A., Christensen, R. O., Rothstein, G. (1982) Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J. Invest. Dermatol. 78: 206-209
5. Brito, A. R. M. S., Antonio, M. A. (1998) Oral anti-inflammatory and anti-ulcerogenic activities of a hydroalcoholic extract and partitioned fractions of Turnera ulmifolia (Turneraceae). J. Ethnopharmacol. 61: 215-228
6. Cabrita, L., Andersen, O. M. (1999) Anthocyanins in blue berries of Vaccinium padifolium. Phytochemistry 52: 1693-1696
7. Colanttuoni, A., Bertuglia, S., Magistretti, M. J., Donato, L. (1991) Effects of Vaccinium myrtillus anthocyanosides on arterial vasomotion. Arzneimittelforschung 41: 905-909
8. Collier, H. O. J., Dinneen, L. C., Johnson, C. A., Schneider, C. (1968) The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br. J. Pharmacol. 32: 295-310
9. Crunkhorn, P., Meacock, S. C. (1971) Mediators of the inflammation induced in the rat paw by carrageenin. Br. J. Pharmacol. 42: 392-402
10. Cuzzocrea, S., Constantino, G., Mazzon, E., Zingarelli, B., De Sarro, A., Caputi, A. P. (1999) Protective effects of Mn (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in paw oedema induced by carrageenan in the rat. Biochem. Pharmacol. 58: 171-176
11. De Young, L. M., Kheifets, J. B., Ballaron, S. J., Young, J. M. (1989) Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacological agents. Agents Actions 26: 335-341
12. Faria, A., Oliveira, J., Neves, P., Gameiro, P., Santos-Buelga, C., Freitas, V., Mateus, N. (2005) Antioxidant properties of prepared blueberry (Vaccinium myrtilus) extracts. J. Agric. Food. Chem. 53: 6896-6902
13. Ferreira, S. H. (1979) A new method for measuring variations of rats paw volumes. J. Pharm. Pharmacol. 31: 648
14. Hunskaar, S., Hole, K. (1987) The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30: 103-114
15. Katsube, N., Iwashita, K., Tsushida, T., Yamaki, K., Kobori, M. (2003) Induction of apoptosis in cancer cells by bilberry (Vaccinium myrtillus) and the anthocyanins. J. Agric. Food. Chem. 51: 68-75
16. Kong, J. M., Chia, L. S., Goh, N. K., Chia, T. F., Brouillard, R. (2003) Analysis and biological activities of anthocyanins. Phytochemistry 64: 923-933
17. Koster, R., Anderson, M., DeBeer, E. J. (1959) Acetic acid analgesic screening. Fed. Proc. 18: 418-420
18. Majno, G., Joris, I. (1996) Cells, tissues and disease: principles of general pathology. Blackwell Science, Cambrigde, MA, p. 293
19. Mazza, G., Kay, C. D., Cottrell, T., Holub, B. J. (2002) Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J. Agric. Food. Chem. 50: 7731-7737
20. Moyer, R. A., Hummer, K. M., Finn, C. E., Frei, B., Wrolstad, R. E. (2002) Anthocyanins, phenolics and antioxidant capacity in diverse small fruits: Vaccinium, Rubus and Ribes. J. Agric. Food. Chem. 50: 519-525
21. Namiki, M. (1990) Antioxidants/antimutagens in food. Crit. Rev. Food. Sci. Nutr. 29: 273-300
22. Niemegeers, C. J. E. (1975) The activity of suprofen on nystatin-induced paw oedema in rats. Arzneimittelforschung 23: 1516-1519
23. Olajide, O. A., Awe, S. O., Makinde, J. M., Ekhelar, A. I., Olusola, A., Morebise, O., Okpako, D. T. (2000) Studies on the anti-inflammatory, antipyretic and analgesic properties of the Alstonia boonei stem bark. J. Ethnopharmacol. 71: 179-186
24. Peterson, J., Dwyer, J. (1998) Flavonoids: dietary occurrence and biochemical activity. Nutr. Res. 12: 1995-2018
25. Rang, H. P., Dale, M. M., Ritter, J. M. (2001) Pharmacology. 4th edn, Guanabara-Koogan, Rio de Janeiro, pp 174-188, p. 691
26. Renaud, S., De Lorgeril, M. (1992) Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339: 1523-1526
27. Salvemini, D., Wang, Z. Q., Bourdon, D. M., Stern, M. K., Currie, M. G., Manning, P. T. (1996) Evidence of peroxynitrite involvement in the carrageenan-induced rat paw oedema. Eur. J. Pharmacol. 303: 217-220
28. Shibata, M., Ohkubo, T., Takahashi, H., Inoki, R. (1989) Modified formalin test: characteristic biphasic pain response. Pain 38: 347-352
29. Singleton, V. L., Rossi, J. R. (1965) Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J. Enol. Vitic. 16: 144
30. Smith, J. A. (1994) Neutrophils, host defense, and inflammation: a double-edged sword. J. Leuk. Biol. 56: 672-686
31. nd edn, W. H. Freeman & Co., NY, Campbell, R.C., pp 175-205, 404-486
32. Strack, D., Wray, V. (1993) The anthocyanins. In: Harborne, J. B. (ed) The Flavonoids, advances in research since 1986. Chapman & Hall, London, p. 1
33. Swingle, K. F., Shideman, F. E. (1972) Phases of the inflammatory response to subcutaneous implantation of a cotton pellet and their modification by certain anti-inflammatory agents. Pharmacol. Exp. Ther. 183: 226-234
34. Tamura, T., Shirai, T., Kosaka, N., Ohmori, K., Takafumi, N. (2002) Pharmacological studies of diacerein in animal models of inflammation, arthritis and bone resorption. Eur. J. Pharmacol. 448: 81-87
35. Tjolsen, A., Berge, O. G., Hunskaar, S., Rosland, J. N., Hole, K. (1992) The formalin test: an evaluation of the method. Pain 51: 5-17
36. Walport, M. J., Duff, G. W. (1993) Cells and mediators of inflammation. In: Maddison, P. J., Isenberg, D. A., Woo, P., Glass, D. N. (ed) Oxford text book of rheumatology. Vol. 1, Oxford University Press, Oxford, NY, pp 285-295
37. Winter, C. A., Risley, E. A., Nuss, G. W. (1962) Carrageenan-induced oedema in hind paw of the rats as an assay for anti-inflammatory drugs. Exp. Biol. Med. 111: 544-547
38. Youdim, K. A., McDonald, J., Kalt, W., Joseph, J. A. (2002) Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults. J. Nutr. Biochem. 13: 282-288
39. Zadernowski, R., Naczk, M., Nesterrowicz, J. (2005) Phenolic acid profiles in some small berries. J. Agric. Food. Chem. 53: 2118-2124