Lack of generalisation between the GABAA receptor agonist, gaboxadol, and allosteric modulators of the benzodiazepine binding site in the rat drug discrimination procedure

Psychopharmacology

Volumn 193, Issue 1, 2007, Pages 151-157

  Michelsen, Signe ^a   Sánchez, Connie ^b   Ebert, Bjarke ^a  

^a H LUNDBECK A S   (Denmark)

^b LUNDBECK RESEARCH USA   (United States)

Author keywords

Diazepam; Drug discrimination; Gaboxadol; Indiplon GABAA receptor; Rat; Zolpidem

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; DIAZEPAM; FLUMAZENIL; GABOXADOL; INDIPLON; ZALEPLON; ZOLPIDEM; ZOPICLONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4,5,6,7-TETRAHYDROISOXAZOLO(5,4-C)PYRIDIN-3-OL; BENZODIAZEPINE DERIVATIVE; ISOXAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DRUG BINDING SITE; DRUG DISCRIMINATION; DRUG DOSE INCREASE; DRUG POTENTIATION; DRUG SELECTIVITY; IN VIVO STUDY; INSTRUMENTAL CONDITIONING; LEARNING; MALE; NONHUMAN; PERCEPTIVE DISCRIMINATION; PRIORITY JOURNAL; RAT; ALLOSTERISM; ANIMAL; BINDING SITE; DISCRIMINATION LEARNING; DRUG EFFECT; DRUG INTERACTION; WISTAR RAT;

ALLOSTERIC REGULATION; ANIMALS; BENZODIAZEPINES; BINDING SITES; DISCRIMINATION LEARNING; DRUG INTERACTIONS; GENERALIZATION (PSYCHOLOGY); ISOXAZOLES; MALE; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 34250198699     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-007-0750-y     Document Type: Article

References (35)

1. 2 agonists in rats. Pharmacol Toxicol 64:165-172
2. Arnt J (1992) Sertindole and several antipsychotic drugs differentially inhibit the discriminative stimulus effects of amphetamine, LSD and St 587 in rats. Behav Pharmacol 3:11-18
3. Arnt J (1996) Inhibitory effects on the discriminative stimulus properties of D-amphetamine by classical and newer antipsychotics do not correlate with antipsychotic activity. Relation to effects on the reward system? Psychopharmacology (Berl) 124:117-125
4. B agonist baclofen. Society for Neuroscience Abstracts 17:465
5. Ator NA (1999) High-dose discrimination training with midazolam: context determines generalization profile. Pharmacol Biochem Behav 64:237-243
6. Ator NA (2003) Selectivity in generalization to GABAergic drugs in midazolam-trained baboons. Pharmacol Biochem Behav 75:435-445
7. Ator NA, Griffiths RR (1986) Discriminative stimulus effects of atypical anxiolytics in baboons and rats. J Pharmacol Exp Ther 237:393-403
8. Ator NA, Griffiths RR (2003)Principles of drug abuse liability assessment in laboratory animals. Drug Alcohol Depend 70:S55-S72
9. A receptors of thalamo-cortical neurons: a molecular target for hypnotics. J Neurosci 25:11513-11520
10. Bienkowski P, Iwinska K, Stefanski R, Kostowski W (1997) Discriminative stimulus properties of ethanol in the rat: differential effects of selective and nonselective benzodiazepine receptor agonists. Pharmacol Biochem Behav 58:969-973
11. Borghese CM, Storustovu SI, Ebert B, Herd MB, Belelli D, Lambert JJ, Marshall G, Wafford KA, Harris RA (2006) The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol. J Pharmacol Exp Ther 316:1360-1368
12. Brown N, Kerby J, Bonnert TP, Whiting PJ, Wafford KA (2002) Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. Br J Pharmacol 136:965-974
13. A receptor mediated conductance in mouse neocortex. Cereb Cortex 16:1134-1141
14. Facklam M, Schoch P, Haefely WE (1992) Relationship between benzodiazepine receptor occupancy and potentiation of gamma-aminobutyric acid-stimulated chloride flux in vitro of four ligands of differing intrinsic efficacies. J Pharmacol Exp Ther 261:1106-1112
15. Frølund B, Ebert B, Kristiansen U, Liljefors T, Krogsgaard-Larsen P (2002) GABA(A) receptor ligands and their therapeutic potentials. Curr Top Med Chem 2:817-832
16. Griffiths RR, Sannerud CA, Ator NA, Brady JV (1992) Zolpidem behavioral pharmacology in baboons: self-injection, discrimination, tolerance and withdrawal. J Pharmacol Exp Ther 260:1199-1208
17. Haug T (1983) Neuropharmacological substitute for diazepam specificity of the diazepam stimulus complex: effect of agonists and antagonists. Eur J Pharmacol 83:221-227
18. A receptor mediates tonic inhibition in thalamic VB neurons. J Neurophysiol 94:4491-4501
19. Jones HE, Balster RL (1998) Muscimol-like discriminative stimulus effects of GABA agonists in rats. Pharmacol Biochem Behav 59:319-326
20. Krogsgaard-Larsen P, Johnston GA, Lodge D, Curtis DR (1977) A new class of GABA agonist. Nature 268:53-55
21. A receptor agonists, partial agonists, and antagonists. Design and therapeutic prospects. J Med Chem 37:2489-2505
22. Krogsgaard-Larsen P, Frølund B, Liljefors T, Ebert B (2004) GABAA agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic. Biochem Pharmacol 68:1573-1580
23. Lelas S, Rowlett JK, Spealman RD, Cook JM, Ma C, Li X, Yin W (2002) Role of GABAA/benzodiazepine receptors containing alpha 1 and alpha 5 subunits in the discriminative stimulus effects of triazolam in squirrel monkeys. Psychopharmacology (Berl) 161:180-188
24. McMahon LR, France CP (2005) Combined discriminative stimulus effects of midazolam with other positive GABAA modulators and GABAA receptor agonists in rhesus monkeys. Psychopharmacology (Berl) 178:400-409
25. Mirza NR, Rodgers RJ, Mathiasen LS (2006) Comparative cue generalization profiles of L-838,417, SL-838,417, SL651498, zolpidem, CL 218,872, ocinaplon, bretazenil, zopiclone and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination. J Pharmacol Exp Ther 316:1291-1299
26. Nielsen EB, Jepsen SA (1985) Antagonism of the amphetamine cue by both classical and atypical antipsychotic drugs. Eur J Pharmacol 111:167-176
27. Nielsen EB, Valentine JD, Holohean AM, Appel JB (1983) Benzodiazepine receptor mediated discriminative cues: effects of GABA-ergic drugs and inverse agonists. Life Sci 33:2213-2220
28. Nutt DJ (2005) Making sense of GABA(A) receptor subtypes: is a new nomenclature needed? J Psychopharmacol 19:219-220
29. Rowlett JK, Lelas S, Spealman RD (2000) Transduction of the discriminative stimulus effects of zolpidem by GABAA/alpha1 receptors. Eur J Pharmacol 406:R9-R10
30. Rush CR, Mumford GK, Griffiths RR (1996) Discriminative stimulus effects of triazolam, zolpidem, oxazepam and caffeine in humans. In: Harris LS (ed) Problems of drug dependence 1995. NIDA Res Monogr 162:248
31. Sanger DJ, Griebel G, Perrault G, Claustre Y, Schoemaker H (1999) Discriminative stimulus effects of drugs acting at GABA(A) receptors: differential profiles and receptor selectivity. Pharmacol Biochem Behav 64:269-273
32. Stórustovu S, Ebert B (2003) Gaboxadol: in vitro interaction studies with benzodiazepines and ethanol suggest functional selectivity. Eur J Pharmacol 467:49-56
33. 2. J Pharmacol Exp Ther 316:1351-1359
34. Vanover KE, Barret JE (1994) Evaluation of the discriminative stimulus effects of the novel sedative hypnotic CL 284,846. Psychopharmacology 115:289-296
35. A receptor agonist gaboxadol: lack of ethanol potentiation and benzodiazepine cross-tolerance. Eur J Pharmacol 482:215-222