LIGHT expression by mucosal T cells may regulate IFN-γ expression in the intestine

Journal of Immunology

Volumn 173, Issue 1, 2004, Pages 251-258

  Cohavy, Offer ^a   Zhou, Jaclyn ^a   Granger, Steve W ^b   Ware, Carl F ^b   Targan, Stephan R ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; GAMMA INTERFERON; GLYCOPROTEIN D; LIGHT PROTEIN; LYMPHOTOXIN; PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNITY; CELL DEATH; CELL SURVIVAL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INTESTINE CELL; INTESTINE MUCOSA; LAMINA PROPRIA; MEDIATOR RELEASE; MEMORY CELL; MUCOSAL IMMUNITY; PHOTORECEPTOR MEMBRANE; PRIORITY JOURNAL; PROTEIN FAMILY; T LYMPHOCYTE ACTIVATION; VIRUS EXPRESSION;

EID: 2942755965     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.1.251     Document Type: Article

References (52)

1. Ware, C. F. 2003. The TNF superfamily. Cytokine Growth Factor Rev. 14:181.
2. Locksley, R. M., N. Killeen, and M. J. Lenardo. 2001. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104:487.
3. Mackay, F., and S. L. Kalled. 2002. TNF ligands and receptors in autoimmunity: an update. Curr. Opin. Immunol. 14:783.
4. Brunner, T. W. 2003. Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology. Semin. Immunol. 15:167.
5. Melchers, F. 2003. Actions of BAFF in B cell maturation and its effects on the development of autoimmune disease. Ann. Rheum. Dis. 62(Suppl. 2):ii25.
6. Shaikh, R. B., S. Santee, S. W. Granger, K. Butrovich, T. Cheung, M. Kronenberg, H. Cheroutre, and C. F. Ware. 2001. Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction. J. Immunol. 167:6330.
7. Wang, J., J. C. Lo, A. Foster, P. Yu, H. M. Chen, Y. Wang, K. Tamada, L. Chen, and Y. X. Fu. 2001. The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J. Clin. Invest. 108:1771.
8. Harrop, J. A., P. C. McDonnell, M. Brigham-Burke, S. D. Lyn, J. Minton, K. B. Tan, K. Dede, J. Spampanato, C. Silverman, P. Hensley, et al. 1998. Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth. J. Biol. Chem. 273:27548.
9. Crowe, P. D., B. N. Walter, K. M. Mohler, C. Otten-Evans, R. A. Black, and C. F. Ware. 1995. A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes. J. Exp. Med. 181:1205.
10. Granger, S. W., K. D. Butrovich, P. Houshmand, W. R. Edwards, and C. F. Ware. 2001. Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis. J. Immunol. 167:5122.
11. Futterer, A., K. Mink, A. Luz, M. H. Kosco-Vilbois, and K. Pfeffer. 1998. The lymphotoxin β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9:59.
12. Yu, K. Y., B. Kwon, J. Ni, Y. Zhai, R. Ebner, and B. S. Kwon. 1999. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J. Biol. Chem. 274:13733.
13. Browning, J. L., I. D. Sizing, P. Lawton, P. R. Bourdon, P. D. Rennert, G. R. Majeau, C. M. Ambrose, C. Hession, K. Miatkowski, D. A. Griffiths, et al. 1997. Characterization of lymphotoxin-αβ complexes on the surface of mouse lymphocytes. J. Immunol. 159:3288.
14. Harrop, J. A., M. Reddy, K. Dede, M. Brigham-Burke, S. Lyn, K. B. Tan, C. Silverman, C. Eichman, R. DiPrinzio, J. Spampanato, et al. 1998. Antibodies to TR2 (herpesvirus entry mediator), a new member of the TNF receptor superfamily, block T cell proliferation, expression of activation markers, and production of cytokines. J. Immunol. 161:1786.
15. Wang, J., T. Chun, J. C. Lo, Q. Wu, Y. Wang, A. Foster, K. Roca, M. Chen, K. Tamada, L. Chen, et al. 2001. The critical role of light, a TNF family member, in T cell development. J. Immunol. 167:5099.
16. Scheu, S., J. Alferink, T. Potzel, W. Barchet, U. Kalinke, and K. Pfeffer. 2002. Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin β in mesenteric lymph node genesis. J. Exp. Med. 195:1613.
17. + T cell function in mice lacking the TNF superfamily member LIGHT. J. Immunol. 168:4832.
18. low T cells. Res. Immunol. 145:357.
19. Rioux, J. D., M. S. Silverberg, M. J. Daly, A. H. Steinhart, R. S. McLeod, A. M. Griffiths, T. Green, T. S. Brettin, V. Stone, S. B. Bull, et al. 2000. Genome-wide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am. J. Hum. Genet. 66:1863.
20. Sartor, R. B. 2003. Innate immunity in the pathogenesis and therapy of 1BD. J. Gastroenterol. 38(Suppl. 15):43.
21. May, E., C. Lambert, W. Holtmeier, A. Hennemann, M. Zeitz, and R. Duchmann. 2002. Regional variation of the αβ T cell repertoire in the colon of healthy individuals and patients with Crohn's disease. Hum. Immunol. 63:467.
22. Duchmann, R., I. Kaiser, E. Hermann, W. Mayet, K. Ewe, and Z. B. Meyer. 1995. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin. Exp. Immunol. 102:448.
23. Strober, W., I. J. Fuss, and R. S. Blumberg. 2002. The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 20:495.
24. + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease: Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 157:1261.
25. + T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J. Exp. Med. 184:241.
26. + T cells. Immunity 1:553.
27. Elliott, M. J., R. N. Maini, M. Feldmann, J. R. Kalden, C. Antoni, J. S. Smolen, B. Leeb, F. C. Breedveld, J. D. Macfarlane, and H. Bijl. 1994. Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis. Lancet 344:1105.
28. Targan, S. R., S. B. Hanauer, S. J. van Deventer, L. Mayer, D. H. Present, T. Braakman, K. L. DeWoody, T. F. Schaible, and P. J. Rutgeerts. 1997. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor a for Crohn's disease: Crohn's Disease cA2 Study Group. N. Engl. J. Med. 337:1029.
29. Bamias, G. M. 2003. Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. J. Immunol. 171:4868.
30. Sanders, D. S. 1998. The differential diagnosis of Crohn's disease and ulcerative colitis. Baillieres Clin. Gastroenterol. 12:19.
31. Targan, S. R., R. L. Deem, M. Liu, S. Wang, and A. Nel. 1995. Definition of a lamina propria T cell responsive state: enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway. J. Immunol. 154:664.
32. Nakayama, G. R., G. Valkirs, D. McGrath, and W. D. Huse. 1996. Improving the copy numbers of antibody fragments expressed on the major coat protein of bacteriophage M13. Immunotechnology 2:197.
33. Rooney, I. A., K. D. Butrovich, A. A. Glass, S. Borboroglu, C. A. Benedict, J. C. Whitbeck, G. H. Cohen, R. J. Eisenberg, and C. F. Ware. 2000. The lymphotoxin-β receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. J. Biol. Chem. 275:14307.
34. Mauri, D. N., R. Ebner, R. I. Montgomery, K. D. Kochel, T. C. Cheung, G. L. Yu, S. Ruben, M. Murphy, R. J. Eisenberg, G. H. Cohen, et al. 1998. LIGHT, a new member of the TNF superfamily, and lymphotoxin a are ligands for herpesvirus entry mediator. Immunity 8:21.
35. Rozen, S., and H. Skaletsky. 2000. Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 132:365.
36. Dutton, R. W., L. M. Bradley, and S. L. Swain. 1998. T cell memory. Annu. Rev. Immunol. 16:201.
37. Morel, Y., J. M. Schiano de Colella, J. Harrop, K. C. Deen, S. D. Holmes, T. A. Wattam, S. S. Khandekar, A. Truneh, R. W. Sweet, J. A. Gastaut, et al. 2000. Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor. J. Immunol. 165:4397.
38. Morel, Y., A. Truneh, R. T. Costello, and D. Olive. 2003. LIGHT, a new TNF superfamily member, is essential for memory T helper cell-mediated activation of dendritic cells. Eur. J. Immunol. 33:3213.
39. Diehl, L., A. T. Den Boer, E. I. van der Voort, C. J. Melief, R. Offringa, and R. E. Toes. 2000. The role of CD40 in peripheral T cell tolerance and immunity. J. Mol. Med. 78:363.
40. Lane, P. 2000. Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th)1 and Th2 cells. J. Exp. Med. 191:201.
41. Tamada, K., K. Shimozaki, A. I. Chapoval, Y. Zhai, J. Su, S. F. Chen, S. L. Hsieh, S. Nagata, J. Ni, and L. Chen. 2000. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J. Immunol. 164:4105.
42. Qiao, L., G. Schurmann, M. Betzler, and S. C. Meuer. 1991. Functional properties of human lamina propria T lymphocytes assessed with mitogenic monoclonal antibodies. Immunol. Res. 10:218.
43. Gonsky, R., R. L. Deem, H. A. Young, and S. R. Targan. 2003. CD2 mediates activation of the IFN-γ intronic STAT binding region in mucosal T cells. Eur. J. Immunol. 33:1152.
44. Abreu-Martin, M. T., and S. R. Targan. 1996. Regulation of immune responses of the intestinal mucosa. Crit. Rev. Immunol. 16:277.
45. Blaser, M. J., R. A. Miller, J. Lacher, and J. W. Singleton. 1984. Patients with active Crohn's disease have elevated serum antibodies to antigens of seven enteric bacterial pathogens. Gastroenterology 87:888.
46. + T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J. Exp. Med. 187:855.
47. high T cells to SCID recipients. J. Immunol. 158:3464.
48. D'Haens, G. R., K. Geboes, M. Peeters, F. Baert, F. Penninckx, and P. Rutgeerts. 1998. Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum. Gastroenterology 114:262.
49. Brandtzaeg, P., I. N. Farstad, and L. Helgeland. 1998. Phenotypes of T cells in the gut. Chem. Immunol. 71:1.
50. Lee, W. H., S. H. Kim, Y. Lee, B. B. Lee, B. Kwon, H. Song, B. S. Kwon, and J. E. Park. 2001. Tumor necrosis factor receptor superfamily 14 is involved in atherogenesis by inducing proinflammatory cytokines and matrix metalloproteinases. Arterioscler. Thromb. Vasc. Biol. 21:2004.
51. Cooper, M. A., T. A. Fehniger, A. Fuchs, M. Colonna, and M. A. Caligiuri. 2004. NK cell and DC interactions. Trends Immunol. 25:47.
52. Wan, X., J. Zhang, H. Luo, G. Shi, E. Kapnik, S. Kim, P. Kanakaraj, and J. Wu. 2002. A TNF family member LIGHT transduces costimulatory signals into human T cells. J. Immunol. 169:6813.