Early pre-pubertal exposure to low-dose oral di(2-ethylhexyl) phthalate does not affect sperm plasma membrane stability, acrosomal integrity or chromatin structure in the post-pubertal boar

Theriogenology

Volumn 68, Issue 2, 2007, Pages 186-195

  Spjuth, L ^a   Johannisson, A ^a   Lundeheim, N ^a   Rodriguez Martinez H ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Acrosome reaction (AR); Boar spermatozoa; Capacitation; Chromatin stability; Di(2 ethylhexyl) phthalate (DEHP)

Indexed keywords

PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PLASTICIZER;

ACROSOME; ACROSOME REACTION; ANIMAL; ARTICLE; CELL MEMBRANE; CHROMATIN; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; MALE; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SEXUAL MATURATION; SPERMATOZOON; SPERMATOZOON CAPACITATION; SWINE; TOXICITY TESTING; ULTRASTRUCTURE;

ACROSOME; ACROSOME REACTION; ADMINISTRATION, ORAL; ANIMALS; CELL MEMBRANE; CHROMATIN; DIETHYLHEXYL PHTHALATE; MALE; PLASTICIZERS; SEXUAL MATURATION; SPERM CAPACITATION; SPERMATOZOA; SWINE; TOXICITY TESTS;

ARACHIS HYPOGAEA; RODENTIA; SUIDAE;

EID: 34250187422     PISSN: 0093691X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.theriogenology.2007.04.051     Document Type: Article

References (61)

1. Fromme H., Kuchler T., Otto T., Pilz K., Muller J., and Wenzel A. Occurrence of phthalates and bisphenol A and F in the environment. Water Res 36 6 (2002) 1429-1438
2. Tsumura Y., Ishimitsu S., Kaihara A., Yoshii K., Nakamura Y., and Tonogai Y. Di(2-ethylhexyl) phthalate contamination of retail packed lunches caused by PVC gloves used in the preparation of foods. Food Addit Contam 18 6 (2001) 569-579
3. Tsumura Y., Ishimitsu S., Saito I., Sakai H., Kobayashi Y., and Tonogai Y. Eleven phthalate esters and di(2-ethylhexyl) adipate in one-week duplicate diet samples obtained from hospitals and their estimated daily intake. Food Addit Contam 18 5 (2001) 449-460
4. Liss G.M., Albro P.W., Hartle R.W., and Stringer W.T. Urine phthalate determinations as an index of occupational exposure to phthalic anhydride and di(2-ethylhexyl) phthalate. Scand J Work Environ Health 11 5 (1985) 381-387
5. Oie L., Hersoug L.G., and Madsen J.O. Residential exposure to plasticizers and its possible role in the pathogenesis of asthma. Environ Health Perspect 105 9 (1997) 972-978
6. Bornehag C.-G., Lundgren B., Weschler C.J., Sigsgaard T., Hagerhed-Engman L., and Sundell J. Phthalates in indoor dust and their association with building characteristics. Environ Health Perspect 113 10 (2005) 1399-1404
7. Biscardi D., Monarca S., De Fusco R., Senatore F., Poli P., Buschini A., et al. Evaluation of the migration of mutagens/carcinogens from PET bottles into mineral water by Tradescantia/micronuclei test. Comet assay on leukocytes and GC/MS. Sci Total Environ 302 (2003) 101-108
8. Casajuana N., and Lacorte S. Presence and release of phthalic esters and other endocrine disrupting compounds in drinking water. Chromatographia 57 (2003) 649-655
9. Tickner J.A., Schettler T., Guidotti T., McCally M., and Rossi M. Health risks posed by use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a critical review. Am J Ind Med 39 (2001) 100-111
10. Agarwal D.K., Eustis S., Lamb I.V.J.C., Reel J.R., and Kluwe W.M. Effects of di(2-ethylhexyl) phthalate on the gonadal pathophysiology, sperm morphology, and reproductive performance of male rats. Environ Health Perspect 65 (1986) 343-350
11. Parmar D., Srivastava S.P., and Seth P.K. Effect of di(2-ethylhexyl) phthalate (DEHP) on spermatogenesis in adult rats. Toxicology 42 1 (1986) 47-55
12. Dalgaard M., Nellerman C., Lam H.R., Sørensen I.K., and Ladefoged O. The acute effects of mono(2-ethylhexyl) phthalate (MEHP) on testes of prepubertal Wistar rats. Toxicol Lett 122 (2001) 69-79
13. Rhodes C., Orton T.C., Pratt I.S., Batten P.L., Bratt H., Jackson S.J., et al. Comparative pharmacokinetics and subacute toxicity of di(2-ethylhexyl) phthalate (DEHP) in rats and marmosets: extrapolation of effects in rodents to man. Environ Health Perspect 65 (1986) 299-308
14. Pugh Jr. G., Isenberg J.S., Kamendulis L.M., Ackley D.C., Clare L.J., Brown R., et al. Effects of di-isononyl phthalate, -2-ehylhexyl hthalate, and clofibrate in cynomolgus monkeys. Toxicol Sci 56 (2000) 181-188
15. Kessler W., Numtip W., Grote K., Csanády G.A., Chahoudd I., and Filser J.G. Blood burden of di(2-ethylhexyl) phthalate and its primary metabolite mono(2-ethylhexyl) phthalate in pregnant and nonpregnant rats and marmosets. Toxicol Appl Pharmacol 195 (2004) 142-153
16. Ljungvall K., Tienpont B., David F., Magnusson U., and Törneke K. Kinetics of orally administered di(2-ethylhexyl) phthalate and its metabolite, mono(2-ethylhexyl) phthalate, in male pigs. Arch Toxicol 78 (2004) 384-389
17. Ljungvall K., Spjuth L., Hultén F., Einarsson S., Rodríguez-Martínez H., Andersson K., et al. Early post natal exposure to low-dose oral di(2-ethylhexyl) phthalate affects the peripheral LH-concentration in plasma, but does not affect mating behaviour in the post-pubertal boar. Reprod Toxicol 21 (2006) 160-166
18. Spjuth L., Ljungvall K., Saravia F., Lundeheim N., Magnusson U., Hultén F., et al. Does exposure to di(2-ethylhexyl) phthalate in prepubertal boars affect semen quality post-puberty?. Int J Androl 29 5 (2006) 534-542
19. Spjuth L., Saravia F., Johannisson A., Lundeheim N., and Rodríguez-Martínez H. Effects of exposure of pre-pubertal boars to di(2-ethylhexyl) phthalate on their frozen-thawed sperm viability post-puberty. Andrologia 38 5 (2006) 186-194
20. Maxwell W.M., and Johnson L.A. Membrane status of boar spermatozoa after cooling or cryopreservation. Theriogenology 48 (1997) 209-219
21. Harrison R.A. Capacitation mechanisms, and the role of capacitation as seen in eutherian mammals. Reprod, Fertil Dev 8 (1996) 581-594
22. Williamson P., Mattocks K., and Schlegel R.A. Merocyanine 540, a fluorescent probe sensitive to lipid packing. Biochim Biophys Acta 732 (1983) 387-393
23. Langner M., and Hui S.W. Merocyanine interaction in phosphatidylcholine bilayers. Biochim Biophys Acta 1149 (1993) 175-179
24. Silva P.F., and Gadella B.M. Detection of damage in mammalian sperm cells. Theriogenology 65 5 (2006) 958-978
25. Harrison R.A., and Gadella B.M. Bicarbonate-induced membrane processing in sperm capacitation. Theriogenology 63 2 (2005) 342-351
26. Gillan L., Evans G., and Maxwell W.M.C. Flow cytometric evaluation of sperm parameters in relation to fertility potential. Theriogenology 63 (2005) 445-457
27. Stähr B., Berg C., Bechtold B., and Müller K. Relations between the amount of in-vitro-capacitated sperm cells after liquid-preservation and the fertility of AI-boars. Proceedings of the 14th International Conference on Antiviral Research (ICAR). Stockholm (2000)
28. Rodríguez-Martínez H., Courtens J.L., Kvist U., and Plöen L. Immunocytochemical localization of nuclear protamine in boar spermatozoa during epididymal transit. J Reprod Fertil 89 (1990) 591-595
29. Spano M., Bonde J., Hjollund H.I., Kolstadt H.A., Cordelli E., and Leter G. Sperm chromatin damage impairs human fertility. Fertil Steril 73 (2000) 43-50
30. Peris S.I., Morrier A., Dufour M., and Bailey J.L. Cryopreservation of ram semen facilitates sperm DNA damage: relationship between sperm andrological parameters and the sperm chromatin structure assay. J Androl 25 (2004) 224-233
31. Fraser L. Structural damage to nuclear DNA in mammalian spermatozoa: its evaluation techniques and relationship with male fertility. Pol J Vet Sci 7 (2004) 311-321
32. Evenson D.P., and Wixon R. Clinical aspects of sperm DNA fragmentation detection and male infertility. Theriogenology 65 (2006) 979-991
33. Evenson D.P., Darzynkiewicz Z., and Melamed M.R. Relation of mammalian sperm chromatin heterogeneity to fertility. Science 210 (1980) 1131-1133
34. Hernández M., Roca J., Ballester J., Vazquez J.M., Martínez E.A., Johannisson A., et al. SCSA outcome discloses differences in freezability of boar spermatozoa. Int J Androl 29 6 (2006) 583-591
35. Evenson D.P., Thompson L., and Jost L. Flow cytometric evaluation of boar semen by the sperm chromatin structure assay as related to cryopreservation and fertility. Theriogenology 41 (1994) 637-651
36. Ljungvall K. Prepubertal exposure to di(2-ethylhexyl) phthalate. Doctoral thesis no. 2006:15. Uppsala, Sweden: Swedish University of Agricultural Sciences (SLU).
37. Januskauskas A., Lukoseviciute K., Nagy S., Johannisson A., and Rodríguez-Martínez H. Assessment of the efficacy of Sephadex G-15 filtration of bovine spermatozoa for cryopreservation. Theriogenology 63 1 (2005) 160-178
38. Evenson D.P., Larson K.L., and Jost L.K. Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl 23 1 (2002) 25-43
39. Evenson D.P., and Jost L. Sperm chromatin structure assay is useful for fertility assessment. Methods Cell Sci 22 (2000) 169-189
40. Januskauskas A., Johannisson A., and Rodríguez-Martínez H. Assessment of sperm quality through fluorometry and sperm chromatin structure assay in relation to field fertility of frozen-thawed semen from Swedish AI bulls. Theriogenology 55 (2001) 947-961
41. Hernández M., Roca J., Ballester J., Vázquez J.M., Marti{dotless}ínez E.A., Johannisson A., et al. Differences in SCSA outcome among boars with different sperm freezability. Int J Androl 29 (2006) 583-591
42. Ohl D.A., and Menge A.C. Assessment of sperm function and clinical aspects of impaired sperm function. Front Biosci 1 (1996) e96-e108
43. Aitken R.J. Sperm function tests and fertility. Int J Androl 29 (2006) 69-75
44. Norgil Damgaard I., Main K.M., Toppari J., and Skakkebaek N.E. Impact of exposure to endocrine disrupters in utero and in childhood on adult reproduction. Best Pract Res Clin Endocrinol Metab 16 2 (2002) 289-309
45. Park J.D., Habeebu S.S.M., and Klaassen C.D. Testicular toxicity of di(2-ethylhexyl) phthalate in young Sprague-Dawley rats. Toxicology 171 2-3 (2002) 105-115
46. Swindle M.M., Smith A.C., and Hepburn B.J. Swine as models in experimental surgery. J Invest Surg 1 (1988) 65-79
47. Smith A.C., and Swindle M.M. Preparation of swine for laboratory. ILAR J 47 (2006) 358-363
48. Brock J.W., Caudill S.P., Silva M.J., Needham L.L., and Hilborn E.D. Phthalate monoester levels in the urine of young children. Bull Environ Contam Toxicol 68 (2002) 309-314
49. Koch H.M., Drexler H., and Angerer J. An estimation of the daily intake of di(2-ethylhexyl) phthalate (DEHP) and other phthalates in the general population. Int J Hyg Environ Health 206 (2003) 77-83
50. Koch H.M., Rossbach B., Drexler H., and Angerer J. Internal exposure of the general population to DEHP and other phthalates-determination of secondary and primary phthalate monoester metabolites in urine. Environ Res 93 (2003) 177-185
51. Koch H.M., Drexler H., and Angerer J. Internal exposure of nursery-school children and their parents and teachers to di(2-ethylhexyl) phthalate (DEHP). Int J Hyg Environ Health 207 (2004) 15-22
52. Duty S.M., Silva M.J., Barr D.B., Brock J.W., Ryan L., Chen Z., et al. Phthalate exposure and human semen parameters. Epidemiology 14 (2003) 269-277
53. Jönsson B.A.G., Richthoff J., Rylander L., Giwercman A., and Hagmar L. Urinary phthalate metabolites and biomarkers of reproductive function in young men. Epidemiology 16 (2005) 487-493
54. Hauser R., Meeker J.D., Duty S., Silva M.J., and Calafat A.M. Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. Epidemiology 17 6 (2006) 682-691
55. Zhang Y.H., Zheng L.X., and Chen B.H. Phathalate exposure and human semen quality in Shanghai: a cross-sectional study. Biomed Environ Sci 19 (2006) 205-209
56. Watson P.F. The causes of reduced fertility with cryopreserved semen. Anim Reprod Sci 60-61 (2000) 481-492
57. Smistad G., Waaler T., and Roksvaag P.O. Migration of plastic additives from soft polyvinyl chloride bags into normal saline and glucose infusions. Acta Pharmacol Nordica 1 (1989) 287-290
58. Loff S., Kabs F., Witt K., Sartoris J., Mandl B., Niessen K.H., et al. Polyvinylchloride infusion lines expose infants to large amounts of toxic plasticizers. J Pediatr Surg 35 (2000) 1775-1781
59. Inoue K., Kawaguchi M., Yamanaka R., Higuchi T., Ito R., Saito K., et al. Evaluation and analysis of exposure levels of di(2-ethylhexyl) phthalate from blood bags. Clin Chim Acta 358 (2005) 159-166
60. Weuve J., Sánchez B.N., Calafat A.M., Schettler T., Green R.A., Hu H., et al. Exposure to phthalates in neonatal intensive care unit infants: urinary concentrations of monoesters and oxidative metabolites. Environ Health Perspect 114 (2006) 1424-1431
61. Rybar R., Faldikova L., Faldyna M., Machatkova M., and Rubes J. Bull and boar sperm DNA integrity evaluated by sperma chromatin structure assay in Czech Republic. Vet Med (Czech) 1 (2004) 1-8