메뉴 건너뛰기




Volumn 17, Issue 3, 2007, Pages 179-185

Insulin-like growth factor binding protein-5 in osteogenesis: Facilitator or inhibitor?

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 4; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN BINDING PROTEIN 6; SOMATOMEDIN RECEPTOR;

EID: 34250004672     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2007.01.005     Document Type: Review
Times cited : (29)

References (49)
  • 1
    • 33645560435 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis
    • Beattie J., Allan G.J., Lochrie J.D., and Flint D.J. Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis. Biochem. J. 395 (2006) 1-19
    • (2006) Biochem. J. , vol.395 , pp. 1-19
    • Beattie, J.1    Allan, G.J.2    Lochrie, J.D.3    Flint, D.J.4
  • 2
    • 0032565746 scopus 로고    scopus 로고
    • Role of insulin-like growth factor binding proteins in controlling IGF actions
    • Clemmons D.R. Role of insulin-like growth factor binding proteins in controlling IGF actions. Mol. Cell Endocrinol. 140 (1998) 19-24
    • (1998) Mol. Cell Endocrinol. , vol.140 , pp. 19-24
    • Clemmons, D.R.1
  • 4
    • 0036803018 scopus 로고    scopus 로고
    • IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
    • Mohan S., and Baylink D.J. IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms. J. Endocrinol. 175 (2002) 19-31
    • (2002) J. Endocrinol. , vol.175 , pp. 19-31
    • Mohan, S.1    Baylink, D.J.2
  • 5
    • 0036905115 scopus 로고    scopus 로고
    • Cellular actions of the insulin-like growth factor binding proteins
    • Firth S.M., and Baxter R.C. Cellular actions of the insulin-like growth factor binding proteins. Endocr. Rev. 23 (2002) 824-854
    • (2002) Endocr. Rev. , vol.23 , pp. 824-854
    • Firth, S.M.1    Baxter, R.C.2
  • 6
    • 0032540928 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein (IGFBP)-3 and IGFBP-5 share a common nuclear transport pathway in T47D human breast carcinoma cells
    • Schedlich L.J., Young T.F., Firth S.M., and Baxter R.C. Insulin-like growth factor-binding protein (IGFBP)-3 and IGFBP-5 share a common nuclear transport pathway in T47D human breast carcinoma cells. J. Biol. Chem. 273 (1998) 18347-18352
    • (1998) J. Biol. Chem. , vol.273 , pp. 18347-18352
    • Schedlich, L.J.1    Young, T.F.2    Firth, S.M.3    Baxter, R.C.4
  • 7
    • 0036126026 scopus 로고    scopus 로고
    • IGF-binding protein-5: flexible player in the IGF system and effector on its own
    • Schneider M.R., Wolf E., Hoeflich A., and Lahm H. IGF-binding protein-5: flexible player in the IGF system and effector on its own. J. Endocrinol. 172 (2002) 423-440
    • (2002) J. Endocrinol. , vol.172 , pp. 423-440
    • Schneider, M.R.1    Wolf, E.2    Hoeflich, A.3    Lahm, H.4
  • 8
    • 0034674710 scopus 로고    scopus 로고
    • Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions
    • Imai Y., Moralez A., Andag U., Clarke J.B., Busby Jr. W.H., and Clemmons D.R. Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions. J. Biol. Chem. 275 (2000) 18188-18194
    • (2000) J. Biol. Chem. , vol.275 , pp. 18188-18194
    • Imai, Y.1    Moralez, A.2    Andag, U.3    Clarke, J.B.4    Busby Jr., W.H.5    Clemmons, D.R.6
  • 9
    • 0032538802 scopus 로고    scopus 로고
    • Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions
    • Kalus W., Zweckstetter M., Renner C., Sanchez Y., Georgescu J., Grol M., Demuth D., Schumacher R., Dony C., Lang K., and Holak T.A. Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions. EMBO J. 17 (1998) 6558-6572
    • (1998) EMBO J. , vol.17 , pp. 6558-6572
    • Kalus, W.1    Zweckstetter, M.2    Renner, C.3    Sanchez, Y.4    Georgescu, J.5    Grol, M.6    Demuth, D.7    Schumacher, R.8    Dony, C.9    Lang, K.10    Holak, T.A.11
  • 10
    • 0028029340 scopus 로고
    • Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes
    • Arai T., Parker A., Busby Jr. W., and Clemmons D.R. Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes. J. Biol. Chem. 269 (1994) 20388-20393
    • (1994) J. Biol. Chem. , vol.269 , pp. 20388-20393
    • Arai, T.1    Parker, A.2    Busby Jr., W.3    Clemmons, D.R.4
  • 11
    • 0029997775 scopus 로고    scopus 로고
    • Identification of the extracellular matrix binding sites for insulin-like growth factor-binding protein 5
    • Parker A., Clarke J.B., Busby Jr. W.H., and Clemmons D.R. Identification of the extracellular matrix binding sites for insulin-like growth factor-binding protein 5. J. Biol. Chem. 271 (1996) 13523-13529
    • (1996) J. Biol. Chem. , vol.271 , pp. 13523-13529
    • Parker, A.1    Clarke, J.B.2    Busby Jr., W.H.3    Clemmons, D.R.4
  • 12
    • 0033995216 scopus 로고    scopus 로고
    • Overlap of IGF- and heparin-binding sites in rat IGF-binding protein-5
    • Song H., Beattie J., Campbell I.W., and Allan G.J. Overlap of IGF- and heparin-binding sites in rat IGF-binding protein-5. J. Mol. Endocrinol. 24 (2000) 43-51
    • (2000) J. Mol. Endocrinol. , vol.24 , pp. 43-51
    • Song, H.1    Beattie, J.2    Campbell, I.W.3    Allan, G.J.4
  • 13
    • 0032582661 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain
    • Twigg S.M., Kiefer M.C., Zapf J., and Baxter R.C. Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain. J. Biol. Chem. 273 (1998) 28791-28798
    • (1998) J. Biol. Chem. , vol.273 , pp. 28791-28798
    • Twigg, S.M.1    Kiefer, M.C.2    Zapf, J.3    Baxter, R.C.4
  • 14
    • 0032513133 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit
    • Twigg S.M., and Baxter R.C. Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit. J. Biol. Chem. 273 (1998) 6074-6079
    • (1998) J. Biol. Chem. , vol.273 , pp. 6074-6079
    • Twigg, S.M.1    Baxter, R.C.2
  • 15
    • 0027248393 scopus 로고
    • Carboxy-truncated insulin-like growth factor binding protein-5 stimulates mitogenesis in osteoblast-like cells
    • Andress D.L., Loop S.M., Zapf J., and Kiefer M.C. Carboxy-truncated insulin-like growth factor binding protein-5 stimulates mitogenesis in osteoblast-like cells. Biochem. Biophys. Res. Commun. 195 (1993) 25-30
    • (1993) Biochem. Biophys. Res. Commun. , vol.195 , pp. 25-30
    • Andress, D.L.1    Loop, S.M.2    Zapf, J.3    Kiefer, M.C.4
  • 16
    • 0026499350 scopus 로고
    • Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action
    • Andress D.L., and Birnbaum R.S. Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action. J. Biol. Chem. 267 (1992) 22467-22472
    • (1992) J. Biol. Chem. , vol.267 , pp. 22467-22472
    • Andress, D.L.1    Birnbaum, R.S.2
  • 17
    • 0037168495 scopus 로고    scopus 로고
    • ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts
    • Mohan S., Thompson G.R., Amaar Y.G., Hathaway G., Tschesche H., and Baylink D.J. ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts. Biochemistry 41 (2002) 15394-15403
    • (2002) Biochemistry , vol.41 , pp. 15394-15403
    • Mohan, S.1    Thompson, G.R.2    Amaar, Y.G.3    Hathaway, G.4    Tschesche, H.5    Baylink, D.J.6
  • 18
    • 0029121178 scopus 로고
    • Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation
    • Thrailkill K.M., Quarles L.D., Nagase H., Suzuki K., Serra D.M., and Fowlkes J.L. Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation. Endocrinology 136 (1995) 3527-3533
    • (1995) Endocrinology , vol.136 , pp. 3527-3533
    • Thrailkill, K.M.1    Quarles, L.D.2    Nagase, H.3    Suzuki, K.4    Serra, D.M.5    Fowlkes, J.L.6
  • 19
    • 0027212152 scopus 로고
    • Regulation and biological effect of endogenous insulin-like growth factor binding protein-5 in human osteoblastic cells
    • Conover C.A., and Kiefer M.C. Regulation and biological effect of endogenous insulin-like growth factor binding protein-5 in human osteoblastic cells. J. Clin. Endocrinol. Metab. 76 (1993) 1153-1159
    • (1993) J. Clin. Endocrinol. Metab. , vol.76 , pp. 1153-1159
    • Conover, C.A.1    Kiefer, M.C.2
  • 20
    • 0030988934 scopus 로고    scopus 로고
    • Phosphorylation of insulin-like growth factor binding proteins
    • Coverley J.A., and Baxter R.C. Phosphorylation of insulin-like growth factor binding proteins. Mol. Cell Endocrinol. 128 (1997) 1-5
    • (1997) Mol. Cell Endocrinol. , vol.128 , pp. 1-5
    • Coverley, J.A.1    Baxter, R.C.2
  • 21
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
    • Liu J.P., Baker J., Perkins A.S., Robertson E.J., and Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75 (1993) 59-72
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, A.S.3    Robertson, E.J.4    Efstratiadis, A.5
  • 24
    • 33746589894 scopus 로고    scopus 로고
    • Transgenic mice with osteoblast-targeted insulin-like growth factor-I show increased bone remodeling
    • Jiang J., Lichtler A.C., Gronowicz G.A., Adams D.J., Clark S.H., Rosen C.J., and Kream B.E. Transgenic mice with osteoblast-targeted insulin-like growth factor-I show increased bone remodeling. Bone 39 (2006) 494-504
    • (2006) Bone , vol.39 , pp. 494-504
    • Jiang, J.1    Lichtler, A.C.2    Gronowicz, G.A.3    Adams, D.J.4    Clark, S.H.5    Rosen, C.J.6    Kream, B.E.7
  • 27
    • 0025728992 scopus 로고
    • Isolation of a novel insulin-like growth factor (IGF) binding protein from human bone: a potential candidate for fixing IGF-II in human bone
    • Bautista C.M., Baylink D.J., and Mohan S. Isolation of a novel insulin-like growth factor (IGF) binding protein from human bone: a potential candidate for fixing IGF-II in human bone. Biochem. Biophys. Res. Commun. 176 (1991) 756-763
    • (1991) Biochem. Biophys. Res. Commun. , vol.176 , pp. 756-763
    • Bautista, C.M.1    Baylink, D.J.2    Mohan, S.3
  • 28
    • 0032824874 scopus 로고    scopus 로고
    • Expression of the components of the insulin-like growth factor axis across the growth-plate
    • Olney R.C., and Mougey E.B. Expression of the components of the insulin-like growth factor axis across the growth-plate. Mol. Cell Endocrinol. 156 (1999) 63-71
    • (1999) Mol. Cell Endocrinol. , vol.156 , pp. 63-71
    • Olney, R.C.1    Mougey, E.B.2
  • 29
    • 0034764356 scopus 로고    scopus 로고
    • Intact IGF-binding protein-4 and -5 and their respective fragments isolated from chronic renal failure serum differentially modulate IGF-I actions in cultured growth plate chondrocytes
    • Kiepe D., Andress D.L., Mohan S., Standker L., Ulinski T., Himmele R., Mehls O., and Tonshoff B. Intact IGF-binding protein-4 and -5 and their respective fragments isolated from chronic renal failure serum differentially modulate IGF-I actions in cultured growth plate chondrocytes. J. Am. Soc. Nephrol. 12 (2001) 2400-2410
    • (2001) J. Am. Soc. Nephrol. , vol.12 , pp. 2400-2410
    • Kiepe, D.1    Andress, D.L.2    Mohan, S.3    Standker, L.4    Ulinski, T.5    Himmele, R.6    Mehls, O.7    Tonshoff, B.8
  • 30
    • 0028298830 scopus 로고
    • Changes in insulin-like growth factor-binding protein expression and secretion during the proliferation, differentiation, and mineralization of primary cultures of rat osteoblasts
    • Birnbaum R.S., and Wiren K.M. Changes in insulin-like growth factor-binding protein expression and secretion during the proliferation, differentiation, and mineralization of primary cultures of rat osteoblasts. Endocrinology 135 (1994) 223-230
    • (1994) Endocrinology , vol.135 , pp. 223-230
    • Birnbaum, R.S.1    Wiren, K.M.2
  • 31
    • 0030997237 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I, -II, IGF binding proteins (IGFBP)-3, -4, and -5 levels in the conditioned media of normal human bone cells are skeletal site-dependent
    • Malpe R., Baylink D.J., Linkhart T.A., Wergedal J.E., and Mohan S. Insulin-like growth factor (IGF)-I, -II, IGF binding proteins (IGFBP)-3, -4, and -5 levels in the conditioned media of normal human bone cells are skeletal site-dependent. J. Bone Miner. Res. 12 (1997) 423-430
    • (1997) J. Bone Miner. Res. , vol.12 , pp. 423-430
    • Malpe, R.1    Baylink, D.J.2    Linkhart, T.A.3    Wergedal, J.E.4    Mohan, S.5
  • 32
    • 0029433536 scopus 로고
    • Expression, effects, and fate of IGFBP-5 are different in normal and malignant osteoblastic cells
    • Schmid C., Schlapfer I., Gosteli-Peter M.A., Froesch E.R., and Zapf J. Expression, effects, and fate of IGFBP-5 are different in normal and malignant osteoblastic cells. Prog. Growth Factor Res. 6 (1995) 167-173
    • (1995) Prog. Growth Factor Res. , vol.6 , pp. 167-173
    • Schmid, C.1    Schlapfer, I.2    Gosteli-Peter, M.A.3    Froesch, E.R.4    Zapf, J.5
  • 33
    • 0031848362 scopus 로고    scopus 로고
    • Insulin-like growth factors sustain insulin-like growth factor-binding protein-5 expression in osteoblasts
    • Gabbitas B., and Canalis E. Insulin-like growth factors sustain insulin-like growth factor-binding protein-5 expression in osteoblasts. Am. J. Physiol. 275 (1998) E222-E228
    • (1998) Am. J. Physiol. , vol.275
    • Gabbitas, B.1    Canalis, E.2
  • 34
    • 0028227855 scopus 로고
    • Complex pattern of insulin-like growth factor binding protein expression in primary rat osteoblast enriched cultures: regulation by prostaglandin E2, growth hormone, and the insulin-like growth factors
    • McCarthy T.L., Casinghino S., Centrella M., and Canalis E. Complex pattern of insulin-like growth factor binding protein expression in primary rat osteoblast enriched cultures: regulation by prostaglandin E2, growth hormone, and the insulin-like growth factors. J. Cell Physiol. 160 (1994) 163-175
    • (1994) J. Cell Physiol. , vol.160 , pp. 163-175
    • McCarthy, T.L.1    Casinghino, S.2    Centrella, M.3    Canalis, E.4
  • 35
    • 0029991736 scopus 로고    scopus 로고
    • Transcriptional regulation of insulin-like growth factor-binding protein-5 by prostaglandin E2 in osteoblast cells
    • Pash J.M., and Canalis E. Transcriptional regulation of insulin-like growth factor-binding protein-5 by prostaglandin E2 in osteoblast cells. Endocrinology 137 (1996) 2375-2382
    • (1996) Endocrinology , vol.137 , pp. 2375-2382
    • Pash, J.M.1    Canalis, E.2
  • 36
    • 0030593656 scopus 로고    scopus 로고
    • 1 alpha,25-dihydroxyvitamin D3 increases IGF binding protein-5 expression in cultured osteoblasts
    • Schmid C., Schlapfer I., Gosteli-Peter M.A., Hauri C., Froesch E.R., and Zapf J. 1 alpha,25-dihydroxyvitamin D3 increases IGF binding protein-5 expression in cultured osteoblasts. FEBS Lett. 392 (1996) 21-24
    • (1996) FEBS Lett. , vol.392 , pp. 21-24
    • Schmid, C.1    Schlapfer, I.2    Gosteli-Peter, M.A.3    Hauri, C.4    Froesch, E.R.5    Zapf, J.6
  • 37
    • 0028958851 scopus 로고
    • Skeletal growth factors regulate the synthesis of insulin-like growth factor binding protein-5 in bone cell cultures
    • Canalis E., and Gabbitas B. Skeletal growth factors regulate the synthesis of insulin-like growth factor binding protein-5 in bone cell cultures. J. Biol. Chem. 270 (1995) 10771-10776
    • (1995) J. Biol. Chem. , vol.270 , pp. 10771-10776
    • Canalis, E.1    Gabbitas, B.2
  • 38
    • 14144249534 scopus 로고    scopus 로고
    • Osteoblast-specific expression of insulin-like growth factor-1 in bone of transgenic mice induces insulin-like growth factor binding protein-5
    • Rutter M.M., Markoff E., Clayton L., Akeno N., Zhao G., Clemens T.L., and Chernausek S.D. Osteoblast-specific expression of insulin-like growth factor-1 in bone of transgenic mice induces insulin-like growth factor binding protein-5. Bone 36 (2005) 224-231
    • (2005) Bone , vol.36 , pp. 224-231
    • Rutter, M.M.1    Markoff, E.2    Clayton, L.3    Akeno, N.4    Zhao, G.5    Clemens, T.L.6    Chernausek, S.D.7
  • 39
    • 0034751461 scopus 로고    scopus 로고
    • The complex of recombinant human insulin-like growth factor-I (rhIGF-I) and its binding protein-5 (IGFBP-5) induces local bone formation in murine calvariae and in rat cortical bone after local or systemic administration
    • Bauss F., Lang K., Dony C., and Kling L. The complex of recombinant human insulin-like growth factor-I (rhIGF-I) and its binding protein-5 (IGFBP-5) induces local bone formation in murine calvariae and in rat cortical bone after local or systemic administration. Growth Horm. IGF. Res. 11 (2001) 1-9
    • (2001) Growth Horm. IGF. Res. , vol.11 , pp. 1-9
    • Bauss, F.1    Lang, K.2    Dony, C.3    Kling, L.4
  • 41
    • 0033305191 scopus 로고    scopus 로고
    • Recombinant human insulin-like growth factor-binding protein-5 stimulates bone formation parameters in vitro and in vivo
    • Richman C., Baylink D.J., Lang K., Dony C., and Mohan S. Recombinant human insulin-like growth factor-binding protein-5 stimulates bone formation parameters in vitro and in vivo. Endocrinology 140 (1999) 4699-4705
    • (1999) Endocrinology , vol.140 , pp. 4699-4705
    • Richman, C.1    Baylink, D.J.2    Lang, K.3    Dony, C.4    Mohan, S.5
  • 42
    • 0033304753 scopus 로고    scopus 로고
    • Effects of recombinant insulin-like growth factor-binding protein-4 on bone formation parameters in mice
    • Miyakoshi N., Richman C., Qin X., Baylink D.J., and Mohan S. Effects of recombinant insulin-like growth factor-binding protein-4 on bone formation parameters in mice. Endocrinology 140 (1999) 5719-5728
    • (1999) Endocrinology , vol.140 , pp. 5719-5728
    • Miyakoshi, N.1    Richman, C.2    Qin, X.3    Baylink, D.J.4    Mohan, S.5
  • 43
    • 0029130195 scopus 로고
    • Studies on the mechanisms by which insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells
    • Mohan S., Nakao Y., Honda Y., Landale E., Leser U., Dony C., Lang K., and Baylink D.J. Studies on the mechanisms by which insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells. J. Biol. Chem. 270 (1995) 20424-20431
    • (1995) J. Biol. Chem. , vol.270 , pp. 20424-20431
    • Mohan, S.1    Nakao, Y.2    Honda, Y.3    Landale, E.4    Leser, U.5    Dony, C.6    Lang, K.7    Baylink, D.J.8
  • 45
    • 0036773550 scopus 로고    scopus 로고
    • Transgenic mice overexpressing insulin-like growth factor binding protein-5 display transiently decreased osteoblastic function and osteopenia
    • Devlin R.D., Du Z., Buccilli V., Jorgetti V., and Canalis E. Transgenic mice overexpressing insulin-like growth factor binding protein-5 display transiently decreased osteoblastic function and osteopenia. Endocrinology 143 (2002) 3955-3962
    • (2002) Endocrinology , vol.143 , pp. 3955-3962
    • Devlin, R.D.1    Du, Z.2    Buccilli, V.3    Jorgetti, V.4    Canalis, E.5
  • 47
    • 13844307614 scopus 로고    scopus 로고
    • Overexpression of insulin-like growth factor binding protein-5 decreases osteoblastic function in vitro
    • Durant D., Pereira R.M., and Canalis E. Overexpression of insulin-like growth factor binding protein-5 decreases osteoblastic function in vitro. Bone 35 (2004) 1256-1262
    • (2004) Bone , vol.35 , pp. 1256-1262
    • Durant, D.1    Pereira, R.M.2    Canalis, E.3
  • 48
    • 0034095903 scopus 로고    scopus 로고
    • Stimulatory effect of insulin-like growth factor binding protein-5 on mouse osteoclast formation and osteoclastic bone-resorbing activity
    • Kanatani M., Sugimoto T., Nishiyama K., and Chihara K. Stimulatory effect of insulin-like growth factor binding protein-5 on mouse osteoclast formation and osteoclastic bone-resorbing activity. J. Bone Miner. Res. 15 (2000) 902-910
    • (2000) J. Bone Miner. Res. , vol.15 , pp. 902-910
    • Kanatani, M.1    Sugimoto, T.2    Nishiyama, K.3    Chihara, K.4
  • 49
    • 0031958404 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-5 (IGFBP-5) stimulates phosphorylation of the IGFBP-5 receptor
    • Andress D.L. Insulin-like growth factor-binding protein-5 (IGFBP-5) stimulates phosphorylation of the IGFBP-5 receptor. Am. J. Physiol. 274 (1998) E744-E750
    • (1998) Am. J. Physiol. , vol.274
    • Andress, D.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.