Insulin-like growth factor (IGF)-I, -II, IGF binding proteins (IGFBP)- 3, -4, and -5 levels in the conditioned media of normal human bone cells are skeletal site-dependent

Journal of Bone and Mineral Research

Volumn 12, Issue 3, 1997, Pages 423-430

  Malpe, Rashmi ^a,b   Baylink, David J ^a,b   Linkhart, Thomas A ^a,b   Wergedal, Jon E ^a,b   Mohan, Subburaman ^a,b  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 4; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN C;

ARTICLE; BONE METABOLISM; BONE STRENGTH; CELL DIFFERENTIATION; GROWTH REGULATION; HUMAN; HUMAN CELL; MECHANICAL STRESS; OSSIFICATION; OSTEOBLAST; PROTEIN SYNTHESIS REGULATION; TISSUE DISTRIBUTION;

BONE AND BONES; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; DRUG EVALUATION, PRECLINICAL; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 4; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; OSTEOBLASTS; REFERENCE VALUES; STIMULATION, CHEMICAL;

EID: 0030997237     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1997.12.3.423     Document Type: Article

References (47)

1. Mohan S, Baylink DJ 1991 Bone growth factors. Clin Orthop Rel Res 263:30-48.
2. Mohan S, Baylink DJ 1991 The role of insulin-like growth factor-II in the coupling of bone formation to resorption. In: Spencer EM (ed.) Modern Concepts of Insulin-like Growth Factors. Elsevier, New York, NY, U.S.A., pp. 169-184.
3. Canalis E, McCarthy T, Centrella M 1988 Growth factors and the regulation of bone remodeling. J Clin Invest 81:277-281.
4. Zapf J, Froesch ER 1986 Insulin-like growth factors/somatomedins: Structure, secretion, biological actions and physiological role. Horm Res 24:121-130.
5. Johansson AG, Lindh E, Ljunghall S 1992 Insulin-like growth factor I stimulates bone turnover in osteoporosis. Lancet 339:1619.
6. Mochizuki H, Hakeda Y, Wakatsuki N, Usui N, Akashi S, Sato T, Tanaka K, Kumegawa M 1992 Insulin-like growth factor-I supports formation and activation of osteoclasts. Endocrinology 131:1075-1080.
7. Shimazaki S, Ling N 1991 Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5, and -6). Prog Growth Factor Res 1:243-266.
8. Mohan S 1993 Insulin-like growth factor binding proteins in bone cell regulation. Growth Reg 3:65-68.
9. Conover C 1992 Potentiation of insulin-like growth factor (IGF) action by IGF binding protein-3: Studies of underlying mechanism. Endocrinology 130:3191-3199.
10. LaTour D, Mohan S, Linkhart TA, Baylink DJ, Strong DD 1990 Inhibitory insulin-like growth factor binding protein: Cloning, complete sequence and physiological regulation. Mol Endocrinol 4:1806-1814.
11. Bautista CM, Baylink DJ, Mohan S 1991 Isolation of a novel insulin-like growth factor (IGF) binding protein from human bone: A potential candidate for fixing IGF-II in human bone. Biochem Biophys Res Commun 176:756-763.
12. Andress DL, Birnbaum RS 1991 A novel insulin-like growth factor binding protein secreted by osteoblast-like cells. Biochem Biophys Res Commun 176:213-218.
13. Andress DL, Birnbaum RS 1992 Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action. J Biol Chem 267:22467-22472.
14. Jones JI, Gockerman A, Busby WS, Camacho-Hubner C, Clemmons DR 1992 Extracellular matrix contains insulin-like growth factor binding protein-5: Potentiation of the effects of IGF-I. J Cell Biol 121:679-687.
15. 3 in vitro (abstract). J Bone Miner Res 8(Suppl 1):S293.
16. 2, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture. Calcif Tissue Int 53:324-329.
17. Chambers TJ, Evans M, Gardner TN, Turner-Smith A, Chow JW 1993 Induction of bone formation in rat tail vertebrae by mechanical loading. Bone Miner 20:167-178.
18. Lean JM, Jagger CJ, Chambers TJ, Chow JW 1995 Increased insulin-like growth factor I m RNA expression in rat osteocytes in response to mechanical stimulation. Am J Physiol 268:E318-E327.
19. Kasperk C, Wergedal JE, Strong DD, Parley J, Wangerin K, Gropp H, Ziegler R, Baylink DJ 1995 Human bone cell types differ depending on their skeletal site of origin. J Clin Endocrinol Metab 80:2511-2517.
20. Honda Y, Landale EC, Strong DD, Baylink DJ, Mohan S 1995 Recombinant synthesis of insulin-like growth factor binding protein-4 (IGFBP-4): Development, validation and application of a radioimmunoassay for IGFBP-4 in human serum and other biological fluids. J Clin Endocrinol Metab 80:637-647.
21. Mohan S, Libanati C, Dony C, Lang K, Srinivasan N, Baylink DJ 1995 Development, validation and application of a radioimmunoassay for insulin-like growth factor binding protein-5 in human serum and other biological fluids. J Clin Endocrinol Metab 80:2638-2645.
22. Wergedal JE, Mohan S, Lundy M, Baylink DJ 1990 Skeletal growth factor and other growth factors known to be present in bone matrix stimulate proliferation and protein synthesis in human bone cells. J Bone Miner Res 5:179-186.
23. Chevalley T, Strong DD, Mohan S, Baylink DJ, Linkhart TA 1996 Evidence for a role of IGF binding proteins in glucocorticoid inhibition of normal human osteoblast-like proliferation. Eur J Endocrinol 134:591-601.
24. Lowry OH, Rosenbgough NJ, Farr AL, Randall RJ 1951 Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-269.
25. 18 Sep-Pak separation. J Clin Endocrinol Metab 80:637-647.
26. Mohan S, Bautista CM, Herring SJ, Linkhart TA, Baylink DJ 1990 Development of valid methods to measure insulin-like growth factor-I and -II in bone cell conditioned medium. Endocrinology 126:2534-2542.
27. Nakao Y, Hilliker S, Baylink DJ, Mohan S 1994 Studies on the regulation of insulin-like growth factor binding protein-3 secretion in human osteosarcoma cells in vitro. J Bone Miner Res 9:865-872.
28. Towbin H, Staehlin T, Gordon J 1979 Electrophoretic transfer of proteins from acrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354.
29. Lanyon LE 1992 Control of bone architecture by functional load bearing. J Bone Miner Res 7 (Suppl 2):S369-S375.
30. Giannini S, Mohan S, Kasuya J, Galli G, Rotella CM, LeBon TR, Fujita-Yamaguichi Y 1994 Characterization of insulin-like growth factor binding proteins produced by cultured fibroblasts from patients with noninsulin-dependent diabetes mellitus, insulin-dependent diabetes mellitus, and obesity. J Clin Endocrinol Metab 79:1824-1830.
31. Knutsen R, Honda Y, Strong DD, Sampath TK, Baylink DJ, Mohan S 1995 Regulation of insulin-like growth factor system components by osteogenic protein-1 in human bone cells. Endocrinology 136:857-865,
32. Mohan S, Strong DD, Lempert UG, Tremollieres F, Wergedal JE, Baylink DJ 1992 Studies on regulation of insulin-like growth factor binding protein (IGFBP)-3 and IGFBP-4 production in human bone cells. Acta Endocrinol 127:555-564.
33. Lempert UG, Bautista C, Strong DD, Baylink DJ, Mohan S 1991 Purification of a novel human bone-derived insulin-like growth factor binding protein (hBD-IGFBP): A potential candidate for fixing IGF-II in bone (abstract). J Bone Miner Res 6 (Suppl 1):S250.
34. 3 differentially regulates the production of insulin-like growth factor I (IGF-I) and IGF-binding protein-4 in mouse osteoblasts. Endocrinology 129:3139-3146.
35. Conover CA, Kiefer MC 1993 Regulation and biological effect of endogenous insulin-like growth factor binding protein-5 in human osteoblastic cells. J Clin Endocrinol Metab 76:1153-1159.
36. Hassager C, Fitzpatrick LA, Spencer EM, Riggs BL, Conover CA 1992 Basal and regulated secretion of insulin-like growth factor binding proteins in osteoblast-like cells is cell line-specific. J Clin Endocrinol Metab 75(1):228-233.
37. Jones JI, Gockerman A, Busby WH, Wright G, Clemmons DR 1993 Insulin-like growth factor binding protein-1 stimulates cell migration and binds to the α1β5 integrin by means of its Arg-Gly-Asp sequence. Proc Natl Acad Sci USA 90:10553-10557.
38. Oh Y, Muller HL, Pham H, Lamson G, Rosenfeld RG 1992 Non-receptor-mediated, post-transcriptional regulation of insulin-like growth factor binding protein (IGFBP)-3 in Hs578T human breast cancer cells. Endocrinology 7:380-386.
39. Villaudy J, Blat C, Drop SLS, Golde A, Harel L 1994 Difference in biological effects between insulin-like growth factor binding protein 1 and 3. Growth Factors 10:107-114.
40. Valentinis B, Bhala A, DeAngelis T, Baserga R, Cohen P 1995 The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I gene. Mol Endocrinol 9:361-367.
41. Mohan S, Nakao Y, Honda Y, Landale E, Leser U, Dony C, Lang K, Baylink DJ 1995 Studies on the mechanisms by which insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells. J Biol Chem 270:20424-20431.
42. Andress DL 1995 Heparin modulates the binding of insulin-like growth factor binding protein-5 to membrane protein in osteoblastic cells. J Biol Chem 270:28289-28296.
43. Lalou C, Silve C, Rosato R, Segovia B, Binoux M 1994 Interactions between Insulin-like growth factor-I (IGF-I) and the system of plasminogen activators and their inhibitors in the control of IGF-binding protein-3 production and proteolysis in human osteosarcoma cells. Endocrinology 135:2318-2326.
44. Kanzaki S, Hilliker S, Baylink DJ, Mohan S 1994 Evidence that human bone cells in culture produce insulin-like growth factor binding protein-4 and -5 proteases. Endocrinology 134:383-392.
45. Durham SK, De Leon DD, Okazaki R, Riggs BL, Conover CA 1995 Regulation of insulin-like growth factor (IGF)-binding protein-4 availability in normal human osteoblast-like cells: Role of endogenous IGFs. J Clin Endocrinol Metab 80:104-110.
46. Durham SK, Riggs L, Conover CA 1994 The insulin-like growth factor binding protein-4 (IGFBP-4)-IGFBP-4 protease system in normal human osteoblast-like cells: Regulation by transforming growth factor-β. J Clin Endocrinol Metab 79:1752-1758.
47. Chernausek SD, Smith CE, Duffin KL, Busby WH, Wright G, Clemmons DR 1995 Proteolytic cleavage of insulin-like growth factor binding protein 4 (IGFBP-4). J Biol Chem 270:11377-11382.