Cytomegalovirus (CMV) IE1- and pp65-specific CD8+ T cell responses broaden over time after primary CMV infection in infants

Journal of Infectious Diseases

Volumn 195, Issue 12, 2007, Pages 1789-1798

  Gibson, Laura ^a   Donley, Sheryl ^a   Trzmielina, Sonia ^a   Somasundaran, Mohan ^a   Fisher, Donna ^b   Revello, Maria Grazia ^c   Luzuriaga, Katherine ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; HUMAN; HUMAN CELL; INFANT; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; VIREMIA;

ALLELES; AMINO ACID SEQUENCE; ANTIGENS, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; COHORT STUDIES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; HUMANS; IMMEDIATE-EARLY PROTEINS; INFANT; LEUKOCYTES, MONONUCLEAR; PEPTIDE MAPPING; PHOSPHOPROTEINS; TIME FACTORS; VIRAL LOAD; VIRAL MATRIX PROTEINS; VIRAL PROTEINS;

EID: 34249907536     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/518042     Document Type: Article

References (49)

1. Arvin AM, Fast P, Myers M, Plotkin S, Rabinovich R. Vaccine development to prevent cytomegalovirus disease: report from the National Vaccine Advisory Committee. Clin Infect Dis 2004; 39:233-9.
2. Cannon MJ, Davis KF. Washing our hands of the congenital cytomegalovirus disease epidemic. BMC Public Health 2005; 5:70.
3. Pahl-Seibert MF, Juelch M, Podlech J, et al. Highly protective in vivo function of cytomegalovirus IE1 epitope-specific memory CD8 T cells purified by T-cell receptor-based cell sorting. J Virol 2005; 79:5400-13.
4. Bunde T, Kirchncr A, Hoffmeister B, et al. Protection from cytomegalovirus after transplantation is correlated with immediate early I-specific CD8 T cells. J Exp Med 2005; 201:1031-6.
5. Sacre K, Carcelain G, Cassoux N, et al. Repertoire, diversity, and differentiation of specific CD8 T cells are associated with immune protection against human cytomegalovirus disease. J Exp Med 2005; 201:1999-2010.
6. +-T-cell response to human cytomegalovirus: the 72-kilodalton major immediate-early protein revisited. J Virol 1999; 73:8179-84.
7. Khan N, Cobbold M, Keenan R, Moss PA. Comparative analysis of CD8+ T cell responses against human cytomegalovirus proteins pp65 and immediate early I shows similarities in precursor frequency, oligoclonality, and phenotype. J Infect Dis 2002; 185:1025-34.
8. Wills MR, Carmichael AJ, Mynard K, et al. The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T cell receptor usage of pp65-specific CTL. J Virol 1996; 70:7569-79.
9. Elkington R, Walker S, Crough T, et al. Ex vivo profiling of CD8+-T-cell responses to human cytomegalovirus reveals broad and multispecific reactivities in healthy virus carriers. J Virol 2003; 77:5226-40.
10. Manley TJ, Luy L, Jones T, Boeckh M, Mutimer H, Riddell SR. Immune evasion proteins of human cytomegalovirus do not prevent a diverse CD8+ cytotoxic T-cell response in natural infection. Blood 2004; 104:1075-82.
11. Cao J, McNevin J, Malhotra U, McElrath MJ. Evolution of CD8+ T cell immunity and viral escape following acute HIV-1 infection. J Immunol 2003; 171:3837-46.
12. + T cell responses in EBV infection. J Immunol 2001; 167:4450-7.
13. Lichterfeld M, Yu XG, Cohen D, et al. HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity. AIDS 2004; 18:1383-92.
14. Pudney VA, Leese AM, Rickinson AB, Hislop AD. CD8+ immunodominance among Epstein-Barr virus lytic cycle antigens directly reflects the efficiency of antigen presentation in lytically infected cells. J Exp Med 2005; 201:349-60.
15. Urbani S, Amadei B, Fisicaro P, et al. Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses. Hepatology 2006; 44:126-39.
16. Gibson L, Piccinini G, Lilleri D, et al. Human cytomegalovirus proteins pp65 and immediate early protein 1 are common targets for CD8+ T cell responses in children with congenital or postnatal human cytomegalovirus infection. J Immunol 2004; 172:2256-64.
17. Luzuriaga K, Holmes D, Hereema A, Wong J, Panicali DL, Sullivan JL. HIV-1-specific cytotoxic T lymphocyte responses in the first year of life. J Immunol 1995; 154:433-43.
18. + T cell responses in young HIV-1-infected infants. J Immunol 2001; 167:7134-40.
19. Chen SF, Tu WW, Sharp MA, et al. Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood. J Infect Dis 2004; 189:1619-27.
20. Elbou Ould MA, Luton D, Yadini M, et al. Cellular immune response of fetuses to cytomegalovirus. Pediatr Res 2004; 55:280-6.
21. Lohman BL, Slyker JA, Richardson BA, et al. Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1 )-specific gamma interferon responses during the first year of life in HIV-1-infected infants. J Virol 2005; 79:8121-30.
22. + T lymphocyte response to viral infection during fetal life. J Clin Invest 2003; 111:1747-55.
23. Tu W, Chen S, Sharp M, et al. Persistent and selective deficiency of CD4+ T cell immunity to cytomegalovirus in immunocompetent young children. J Immunol 2004; 172:3260-7.
24. Adkins B. T-cell function in newborn mice and humans. Immunol Today 1999; 20:330-5.
25. Luzuriaga K, Koup RA, Pikora CA, Brettler DB, Sullivan JL. Deficient human immunodeficiency virus type 1-specific cytotoxic T cell responses in vertically infected children. J Pediatr 1991; 119:230-6.
26. Starr SE, Tolpin MD, Friedman HM, Paucker K, Plotkin SA. Impaired cellular immunity to cytomegalovirus in congenitally infected children and their mothers. J Infect Dis 1979; 140:500-5.
27. Jones N, Agrawal D, Elrefaei M, et al. Evaluation of antigen-specific responses using in vitro enriched T cells. J Immunol Methods 2003; 274:139-47.
28. Precopio ML, Sullivan JL, Willard C, Somasundaran M, Luzuriaga K. Differential kinetics and specificity of EBV-specific CD4+ and CD8+ T cells during primary infection. J Immunol 2003; 170:2590-8.
29. Diamond DJ, York J, Sun JY, Wright CL, Forman SJ. Development of a candidate HLA A*0201 restricted peptide-based vaccine against human cytomegalovirus infection. Blood 1997; 90:1751-67.
30. + T-cell epitopes by a computer algorithm and an enzyme-linked immunospot assay. Blood 2001; 98:1872-81.
31. Longmate J, York J, La Rosa C, et al. Population coverage by HLA class-1 restricted cytotoxic T-lymphocytc epitopes, Immunogenetics 2001; 52:165-73.
32. Masuoka M, Yoshimuta T, Hamada M, et al. Identification of the HLA-A24 peptide epitope within cytomegalovirus protein pp65 recognized by CMV-specific cytotoxic T lymphocytes. Viral Immunol 2001; 14:369-77.
33. Bioinformatics and Molecular Analysis Section. HLA peptide binding predictions. Available at: http://thr.cit.nih.gov/molbio/hla_bind. Accessed 13 September 2006.
34. The Immune Epitope Database and Analysis Resource. Available at: http://www.immuneepitope.org. Accessed 13 September 2006.
35. Alexander-Miller MA. High-avidity CD8+ T cells: optimal soldiers in the war against viruses and tumors. Immunol Res 2005; 31:13-24.
36. Price DA, Brenchley JM, Ruff LE, et al. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. J Exp Med 2005; 202:1349-61.
37. Sylwester AW, Mitchell BL, Edgar JB, et al. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med 2005; 202:673-85.
38. Holtappels R, Thomas D, Podlech J, Reddehase MJ. Two antigenic peptides from genes m123 and m164 of murine cytomegalovirus quantitatively dominate CD8 T-cell memory in the H-2d haplotype. J Virol 2002; 76:151-64.
39. Munks MW, Cho KS, Pinto AK, Sierro S, Klenerman P, Hill AB. Four distinct patterns of memory CD8 T cell responses to chronic murine cytomegalovirus infection. J Immunol 2006; 177:450-8.
40. Cao J, McNevin J, Holte S, Fink L, Corey L, McElrath MJ. Comprehensive analysis of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon-secreting CD8+ T cells in primary HIV-1 infection. J Virol 2003; 77:6867-78.
41. Lidehall AK, Sund F, Lundberg T, Eriksson BM, Totterman TH, Korsgren O. T cell control of primary and latent cytomegalovirus infections in healthy subjects. J Clin Immunol 2005; 25:473-81.
42. Klenerman P, Hill A. T cells and viral persistence: lessons from diverse infections. Nat Immunol 2005; 6:873-9.
43. Kondo K, Xu J, Mocarski ES. Human cytomegalovirus latent gene expression in granulocyte-macrophage progenitors in culture and in seropositive individuals. Proc Natl Acad Sci USA 1996; 93:11137-42.
44. Simon CO, Holtappels R, Tervo HM, et al. CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivation. J Virol 2006; 80:10436-56.
45. Reddehase MJ, Balthesen M, Rapp M, Jonjic S, Pavic I, Koszinowski UH. The conditions of primary infection define the load of latent viral genome in organs and the risk of recurrent cytomegalovirus disease. J Exp Med 1994; 179:185-93.
46. Noyola DE, Demmler GJ, Williamson WD, et al. Cytomegalovirus urinary excretion and long term outcome in children with congenital cytomegalovirus infection. Congenital CMV Longitudinal Study Group. Pediatr Infect Dis J 2000; 19:505-10.
47. Hislop AD, Kuo M, Drake-Lee AB, et al. Tonsillar homing of Epstein-Barr virus-specific CD8+ T cells and the virus-host balance. J Clin Invest 2005; 115:2546-55.
48. Holtappels R, Podlech J, Pahl-Seibert MF, et al. Cytomegalovirus misleads its host by priming of CD8 T cells specific for an epitope not presented in infected tissues. J Exp Med 2004; 199:131-6.
49. Selin LK, Brehm MA, Naumov YN, et al. Memory of mice and men: CD8 T-cell cross-reactivity and heterologous immunity. Immunol Rev 2006; 211:164-81.