2-Hydroxy-2′-deoxyadenosine 5′-triphosphate enhances A·T → C·G mutations caused by 8-hydroxy-2′-deoxyguanosine 5′-triphosphate by suppressing its degradation upon replication in a HeLa extract

Biochemistry

Volumn 46, Issue 22, 2007, Pages 6639-6646

  Satou, Kazuya ^a   Kasai, Hiroshi ^b   Masutani, Chikahide ^c   Hanaoka, Fumio ^c   Harashima, Hideyoshi ^a   Kamiya, Hiroyuki ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL EXTRACTS; MUTATION; OXIDIZED DEOXYRIBONUCLEOTIDES; PLASMIDS;

DNA; ENZYME ACTIVITY; HYDROLYSIS; MUTAGENESIS; OXIDATION; REACTION KINETICS;

NUCLEOTIDES;

2 HYDROXY 2' DEOXYADENOSINE 5' TRIPHOSPHATE; 8 HYDROXY 2' DEOXYGUANOSINE 5' TRIPHOSPHATE; ADENINE; ADENOSINE TRIPHOSPHATE DERIVATIVE; CELL EXTRACT; CYTOSINE; DNA POLYMERASE; GUANINE; ISOGUANINE; THYMINE; UNCLASSIFIED DRUG;

ARTICLE; DNA REPLICATION; DNA TEMPLATE; ENZYME DEGRADATION; GENE MUTATION; HUMAN; HUMAN CELL; HYDROLYSIS; MUTAGENICITY; MUTATION RATE; NUCLEIC ACID BASE SUBSTITUTION; PLASMID; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; CELL EXTRACTS; CELL-FREE SYSTEM; CELLS, CULTURED; DEOXYGUANINE NUCLEOTIDES; DNA MUTATIONAL ANALYSIS; DNA REPAIR ENZYMES; DNA REPLICATION; GUANOSINE TRIPHOSPHATE; HELA CELLS; HUMANS; MODELS, GENETIC; MUTAGENESIS; MUTATION; OXYGEN; PHOSPHORIC MONOESTER HYDROLASES;

EID: 34249900986     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi062117r     Document Type: Article

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