Constitutive deletion of the serotonin-7 (5-HT7) receptor decreases electrical and chemical seizure thresholds

Epilepsy Research

Volumn 75, Issue 1, 2007, Pages 39-45

  Witkin, Jeffrey M ^a   Baez, Melvyn ^a   Yu, Jianliang ^a   Barton, Matthew E ^a   Shannon, Harlan E ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

5 HT7 receptors; Cocaine; MES; Mouse; Pentylenetetrazole; Seizures

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; COCAINE; GENOMIC DNA; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; PENTETRAZOLE; SEROTONIN 7 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG DOSE INCREASE; DRUG SELECTIVITY; DRUG TARGETING; GENE SEQUENCE; GENOTYPE; KNOCKOUT MOUSE; MOUSE; NEUROTRANSMISSION; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR GENE; SEIZURE; SEROTONINERGIC SYSTEM;

ANALYSIS OF VARIANCE; ANIMALS; CONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSHOCK; GENE DELETION; MICE; MICE, KNOCKOUT; RECEPTORS, SEROTONIN; SEIZURES;

EID: 34249799004     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2007.03.017     Document Type: Article

References (29)

1. 7 receptor activation decreases slow after hyperpolarization amplitude in CA3 hippocampal pyramidal cells. J. Pharmacol. Exp. Ther. 294 2 (2000) 672-679
2. Bagdy G., Kecskemeti V., Riba P., and Jakus R. Serotonin and epilepsy. J. Neurochem. 100 (2007) 857-873
3. Barton M.E., Klein B.D., Wolf H.H., and White H.S. Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. Epilepsy Res. 47 (2001) 217-227
4. Barton M.E., and Shannon H.E. The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice. Neuroscience 136 2005 (2005) 563-569
5. 7 receptors. J. Neurosci. 24 (2004) 4807-4817
6. 7 receptor distribution and uncovers 8-hydroxy-2-(di-n-propylamino)tetralin interaction with alpha(2) adrenergic receptors. Neuroscience 124 4 (2004) 901-911
7. 7 receptor affinity and protection against sound-induced seizures in DBA/2J mice. Naunyn Schmiedebergs Arch. Pharmacol. 356 6 (1997) 820-826
8. Cardenas C.G., Del Mar L.P., Vysokanov A.V., Arnold P.B., Cardenas L.M., Surmeier D.J., and Scroggs R.S. Serotonergic modulation of hyperpolarization-activated current in acutely isolated rat dorsal root ganglion neurons. J. Physiol. 518 (1999) 507-523
9. 7 receptor-mediated depolarization in the anterodorsal thalamus. I. Pharmacological characterization. J. Pharmacol. Exp. Ther. 297 (2001) 395-402
10. 7 receptor-mediated depolarization in the anterodorsal thalamus. II. Involvement of the hyperpolarization-activated current I(h). J. Pharmacol. Exp. Ther. 297 (2001) 403-409
11. Crabbe J.C., Wahlsten D., and Dudek B.C. Genetics of mouse behavior: interactions with laboratory environment. Science 284 (1999) 1670-1672
12. Eells J.B., Clough R.W., Browning R.A., and Jobe P.C. Comparative fos immunoreactivity in the brain after forebrain, brainstem, or combined seizures induced by electroshock, pentylenetetrazol, focally induced and audiogenic seizures in rats. Neuroscience 123 (2004) 279-292
13. Filakovszky J., Gerber K., and Bagdy G. A serotonin-1A receptor agonist and N-methyl-d-aspartate receptor antagonist oppose each other's effects in a genetic rat epilepsy model. Neurosci. Lett. 261 (1999) 89-92
14. Finney D.J. Probit Analysis. third ed. (1971), Cambridge University Press, Cambridge
15. 7 receptors modulate synchronized network activity in rat hippocampus. Neuropharmacology 42 1 (2002) 82-92
16. 7. J. Med. Chem. 46 (2003) 1-18
17. 7 antagonists decrease epileptic activity in the WAG/Rij rat model of absence epilepsy. Neurosci. Lett. 359 1-2 (2004) 45-48
18. 7 receptor research. Trends Pharamacol. Sci. 25 (2004) 481-486
19. Löscher W., Honack D., Fassbender C.P., and Nolting B. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models. Epilepsy Res. 8 (1991) 171-189
20. McCormick D.A. Cortical and subcortical generators of normal and abnormal rhythmicity. Int. Rev. Neurobiol. 49 (2002) 99-114
21. Pericic D., Lazic J., Jazvinscak Jembrek M., and Svob Strac D. Stimulation of 5-HT 1A receptors increases the seizure threshold for picrotoxin in mice. Eur. J. Pharmacol. 527 (2005) 105-110
22. Sarnyai Z., Sibille E.L., Pavlides C., Fenster R.J., McEwen B.S., and Toth M. Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors. Proc. Natl. Acad. Sci. 97 (2000) 14731-14736
23. 7 receptors: potential treatment of central and peripheral nervous system disorders. Expert Opin. Ther. Patents 14 (2004) 1009-1027
24. 1A receptors in area CA1 of rat hippocampal slices in vitro. J. Neurosci. 15 (1995) 7217-7225
25. Steriade M., McCormick D.A., and Sejnowski T.J. Thalamocortical oscillations in the sleeping and aroused brain. Science 262 (1993) 679-685
26. Strahlendorf J.C., Lee M., and Strahlendorf H.K. Modulatory role of serotonin on GABA-elicited inhibition of cerebellar purkinje cells. Neuroscience 30 (1989) 117-125
27. 7 receptors increase the excitability of rat hippocampal CA1 pyramidal neurons. Brain Res. 993 (2003) 230-234
28. Woodbury D.M., and Davenport V.D. Design and use of new electroshock seizure apparatus, and analysis of factors altering seizure threshold and pattern. Arch. Int. Pharmacodyn. Ther. 92 (1952) 97-104
29. Zhai J., Tian M., Wang Y., JianLiang Yu J., Baez M., and Nisenbaum E.S. Modulation of medial and lateral perforant path excitatory responses in mGlu8 receptor-deficient mice. Neuropharmacology 43 (2002) 223-230