A facile synthesis of 2-substituted-2,3-dihydro-4(1H)-quinazolinones in 2,2,2-trifluoroethanol

Chinese Chemical Letters

Volumn 18, Issue 6, 2007, Pages 656-658

  Qiao, Rong Zhang ^a   Xu, Bai Ling ^b   Wang, Yan Hui ^a  

^a BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

2,3 Dihydro 4(1H) quinazolinone; Fluorinated solvent; Trifluoroethanol (TFE)

Indexed keywords

EID: 34249793207     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cclet.2007.04.036     Document Type: Article

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24. General procedure for the synthesis of 2-substituted-2,3-dihydro-4(1H)-quinazolinones: To a solution of 2-aminobenzamide (2 mmol) in TFE (5 mL) was added the required aldehydes or ketones (6 mmol) and the reaction mixture was refluxed for the stipulated time. The progress of the reaction is monitored by TLC. After completion of the reaction, the product was filtered and purified by recrystallization or chromatography.
25. 2OFNa [M + Na] 265.0747, found 265.0744 (-1.3674 ppm).