Synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: Discovery of a novel aminoguanidinoacetic acid antidiabetic agent

Journal of Medicinal Chemistry

Volumn 44, Issue 8, 2001, Pages 1217-1230

  Larsen, S D ^a   Connell, M A ^a   Cudahy, M M ^a   Evans, B R ^a   May, P D ^a   Meglasson, M D ^a   O'Sullivan, T J ^a   Schostarez, H J ^a   Sih, J C ^a   Stevens, F C ^a   Tanis, S P ^a   Tegley, C M ^a   Tucker, J A ^a   Vaillancourt, V A ^a   Vidmar, T J ^a   Watt, W ^a   Yu, J H ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[2 (AMINOIMINOMETHYL)HYDRAZINO]ACETIC ACID; AMINOGUANIDINOACETIC ACID; ANTIDIABETIC AGENT; ANTIOBESITY AGENT; CARBOXYLIC ACID; CREATINE; CREATINE KINASE; GUANIDINE; GUANIDINOPROPIONIC ACID DERIVATIVE; METFORMIN; PIOGLITAZONE; PNU 10483; TROGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TISSUE LEVEL; ENZYME ACTIVITY; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MUSCLE; NONHUMAN; OBESITY; PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; TREATMENT OUTCOME;

ACETIC ACIDS; ANIMALS; BLOOD GLUCOSE; CARRIER PROTEINS; CELL LINE; CREATINE; CREATINE KINASE; GUANIDINES; HYPOGLYCEMIC AGENTS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, OBESE; MUSCLE, SMOOTH; PHOSPHORYLATION; PROPIONIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035848582     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000095f     Document Type: Article

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