An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children

Current Opinion in Pediatrics

Volumn 17, Issue 2, 2005, Pages 239-245

  Marzullo, Laurie ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Acetaminophen toxicity; Anaphylaxis; Centrilobular necrosis; Glutathione; N acetylcysteine

Indexed keywords

ACETYLCYSTEINE; ACTIVATED CARBON; CIMETIDINE; DIPHENHYDRAMINE; EPHEDRINE; PARACETAMOL;

CHILD; CLINICAL FEATURE; CLINICAL TRIAL; DISEASE EXACERBATION; DOSE RESPONSE; DRUG DETOXIFICATION; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG INDICATION; DRUG INTOXICATION; DRUG SAFETY; GLUTATHIONE METABOLISM; HEART ARREST; HUMAN; HYPOTENSION; LABORATORY TEST; LIVER INJURY; PEDIATRICS; PRACTICE GUIDELINE; PRIORITY JOURNAL; PRURITUS; RASH; RETROSPECTIVE STUDY; REVIEW; SIDE EFFECT; THROAT TIGHTENING; TOXICOKINETICS; TREATMENT OUTCOME; TREATMENT PLANNING; WHEEZING;

ACETAMINOPHEN; ACETYLCYSTEINE; ACUTE DISEASE; ADMINISTRATION, ORAL; ANALGESICS, NON-NARCOTIC; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; EXANTHEMA; HUMANS; INFUSIONS, INTRAVENOUS; LIVER DISEASES; PRACTICE GUIDELINES; PRURITUS;

EID: 17144374465     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mop.0000152622.05168.9e     Document Type: Review

References (20)

1. Watson WA, Litovitz TL, Klein-Schwartz W, et al. Annual Report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 2004; 22:335-386
2. Anker A. Toxins in depth-, acetaminophen. In: Ford MD, Delaney KA, Ling LJ, Erickson T, editors. Clinical toxicology. 1st ed. Philadelphia: W.B. Saunders; 2001. pp. 265-274.
3. Anker AL, Smilkstein MJ. Acetaminopher: concepts and controversies. Emerg Clin North Am 1994; 12:335-349.
4. Kozer E, Koren G. Management of paracetamol overdose: current controversies. Drug Saf 2001; 24:503-512.
5. Rumack BH, Matthew H. Acetaminophen poisoning and toxicity. Pediatrics 1975; 55:871-876.
6. Prescott LF, Park J, Ballantyne A, et al. Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet 1977; 2:432-434.
7. Prescott LF, Illingworth RN, Critchley JA, et al. Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning. BMJ 1979; 2:1097-1100.
8. Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH: Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose: analysis of the national multicenter study (1976-1985). N Engl J Med 1988; 319:1557-1562.
9. Woo OF, Mueller PD, Olson KR, et al. Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose. Ann Emerg Med 2000; 35:363-368.
10. Smilkstein MJ, Bronstein AC, Linden C, et al. Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol. Ann Emerg Med 1991; 20:1058-1063.
11. Perry HE, Shannon MW. Efficacy of oral versus intravenous N-acetylcysteine in acetaminophen overdose: results of an open-label, clinical trial. J Pediatr 1998; 132:149-152.
12. Acetadote: (acetylcysteine) injection. Package insert. Cumberland Pharmaceuticals Inc., Nashville, Tennessee. 2004,
13. Sung L, Simons JA, Dayneka NL. Dilution of intravenous N-acetylcysteine as a cause of hyponatremia. Pediatrics 1997; 100:389-391.
14. Kao LW, Kirk MA, Furbee RB, et al. What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning? Ann Emerg Med 2003; 42:741-750. Studies rate of adverse events with the intravenous use of the oral N-acetylcysteine solution, and suggests guidelines for its use.
15. Yip L, Dart RC, Hurlbut KM: Intravenous administration of N-acetylcysteine. Crit Care Med 1998; 26:40-43.
16. Appelboam AV, Dargan PI, Knighton J: Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma. Emerg Med J 2002; 19:594-595.
17. Bailey B, McGuigan MA. Management of anaphylactoid reactions to intravenous N-acetylcysteine. Ann Emerg Med 1998; 31:710-715.
18. Lynch RM, Robertson R. Anaphylactoid reactions to intravenous N-acetylcysteine: a prospective case controlled study. Accid Emerg Nurs 2004; 12:10-15.
19. Bonfiglio MF, Traeger SM, Hulisz DT, Martin BR. Anaphylactoid reaction to intravenous N-acetylcysteine associated with electrocardiographic abnormalities. Ann Pharmacother 1992; 26:22-25.
20. Mohammed S. Serum sickness-like illness associated with N-acetylcysteine therapy. Ann Pharmacother 1994; 28:285.